Augmentation of Docetaxel-Induced Cytotoxicity in Human PC-3 Androgen-Independent Prostate Cancer Cells by Combination With Four Natural Apoptosis-Inducing Anticancer Compounds [0.03%]
四种天然促凋亡抗癌化合物联合多西他赛诱导人PC-3去势抵抗性前列腺癌细胞毒性的增敏作用研究
Inass A Ahmed,Saly Hafiz,Sabrina van Ginkel et al.
Inass A Ahmed et al.
Docetaxel (DTX) is the treatment of choice for metastatic castration-resistant prostate cancer. However, developing drug resistance is a significant challenge for achieving effective therapy. This study evaluated the anticancer and synergis...
Indirubin Inhibits TRAIL-Induced Activation of Death Receptor 5 in Jurkat Cells [0.03%]
吲哚玉红通过抑制TRAIL诱导的死亡受体5活化阻断CD95聚合和Caspase-8招募及激活
Malaney C Young,Nagamani Vunnam,Robyn T Rebbeck et al.
Malaney C Young et al.
Death receptor 5 (DR5) is an apoptosis-inducing membrane receptor that mediates cell death in several life-threatening conditions. There is a crucial need for the discovery of DR5 antagonists for the therapeutic intervention of conditions i...
Phytochemical characterization and bioactivity toward breast cancer cells of unhydrolyzed and acid-hydrolyzed extracts of Fagonia indica [0.03%]
Fagonia indica未水解和酸水解提取物的植物化学特征及其对乳腺癌细胞的作用
Cristobal L Miranda,Yadano Kumbi,Wenbin Wu et al.
Cristobal L Miranda et al.
Phytochemicals from the genus, Fagonia, have been attracting increasing attention due to their potential beneficial effects on human health. Fagonia species contain various types of phytochemicals such as flavonoids, alkaloids, saponins, te...
PQQ Supplementation and SARS-CoV-2 Spike Protein-Induced Heart Inflammation [0.03%]
PQQ补充与SARS-CoV-2刺突蛋白诱导的心脏炎症关系研究
Alberto Boretti
Alberto Boretti
SARS-CoV-2 spike protein-induced heart inflammation may originate from either COVID-19 infection or the administration of COVID-19 mRNA vaccines. As pyrroloquinoline quinone (PQQ) is a scavenger of free radicals, redox cofactor, and antioxi...
Prediction the Molecular Mechanism of Shengmai Injection in Acute Treatment of COVID-19 Based on Network Pharmacology [0.03%]
基于网络药理学的生脉注射液治疗新冠肺炎急性期分子机制预测研究
Chen Wang,Ao-Lei Liu,He-Zhen Wu et al.
Chen Wang et al.
Objective: To predict the mechanism of Shengmai Injection (SMI) in the acute treatment of COVID-19 by network pharmacology and molecular docking. Methods: Search the compounds in the Traditional Chinese Medicine Systems Pharmacology (TCMSP)...
Oroxylum indicum extract, at a physiologically relevant dosage, does not induce hepatotoxicity in C57BL/6J mice [0.03%]
刺桐提取物以生理相关剂量给药不诱导C57BL/6J小鼠肝毒性
Satyanarayana R Pondugula,Julia M Salamat,Kodye L Abbott et al.
Satyanarayana R Pondugula et al.
Background: Botanical supplements have been proven to provide beneficial health effects. However, they can induce unintended adverse events such as hepatotoxicity. Oroxylum indicum extract (OIE, Sabroxy®) has several hea...
ACEDHARS UNILAG COVID- Response Team;Abidemi J Akindele,Foluso O Agunbiade,Margaret O Sofidiya et al.
ACEDHARS UNILAG COVID- Response Team;Abidemi J Akindele et al.
Coronavirus disease 2019 (COVID-19) is an infection caused by a newly discovered coronavirus which was identified in Wuhan, China. The race is on globally to repurpose drugs for COVID-19 and develop a safe and effective vaccine against the ...
BaMORC: A Software Package for Accurate and Robust 13C Reference Correction of Protein NMR Spectra [0.03%]
BaMORC：一种用于蛋白质NMR谱图的13C参考修正的准确且鲁棒的软件包
Xi Chen,Andrey Smelter,Hunter N B Moseley
Xi Chen
We describe BaMORC, a software package that performs 13C chemical shifts reference correction for either assigned or unassigned peak lists derived from protein NMR spectra. BaMORC provides an intuitive command line interface that allows non...
Pheophorbide Derivatives Isolated from Açaí Berries (Euterpea oleracea) Activate an Antioxidant Response Element In Vitro [0.03%]
从阿萨伊果中分离的叶绿素衍生物能够在体外激活抗氧化反应原件
Suneel K Kandagatla,Robin Tate Uhl,Tyler N Graf et al.
Suneel K Kandagatla et al.
Activity-guided fractionation was used to isolate and identify two components of the Brazilian açaí berry (Euterpe oleracea Mart.) with the ability to induce antioxidant response element (ARE)-dependent gene transcription in human hepatom...
High-Resolution Structural Studies Elucidate Antiatherogenic and Anti-Inflammatory Properties of Peptides Designed to Mimic Amphipathic α-Helical Domains of Apolipoprotein A-I [0.03%]
高分辨率结构研究阐明了设计模仿载脂蛋白A-I的两性α-螺旋域的多肽抗动脉粥样硬化和抗炎特性
Vinod K Mishra,Gattadahalli M Anantharamaiah
Vinod K Mishra
Peptides designed to mimic the antiatherogenic and anti-inflammatory properties of apolipoprotein A-I show that although lipid association is required, not all lipid-associating peptides exhibit these properties. Our studies of a series of ...