Istvan Ladunga
Istvan Ladunga
The Basic Local Alignment Search Tool (BLAST) is the first tool in the annotation of nucleotide or amino acid sequences. BLAST is a flagship of bioinformatics due to its performance and user-friendliness. Beginners and intermediate users wi...
Li Xiyuan,Bu Dechao,Sun Liang et al.
Li Xiyuan et al.
NONCODE is a comprehensive database that aims to present the most complete collection and annotation of non-coding RNAs, especially long non-coding RNAs (lncRNA genes), and thus NONCODE is essential to modern biological and medical research...
Marc Gouw,Hugo Sámano-Sánchez,Kim Van Roey et al.
Marc Gouw et al.
The Eukaryotic Linear Motif (ELM) resource is dedicated to the characterization and prediction of short linear motifs (SLiMs). SLiMs are compact, degenerate peptide segments found in many proteins and essential to almost all cellular proces...
Searching Online Mendelian Inheritance in Man (OMIM): A Knowledgebase of Human Genes and Genetic Phenotypes [0.03%]
在线人类孟德尔遗传信息检索(OMIM)：一个人类基因和遗传性状的知识库
Joanna S Amberger,Ada Hamosh
Joanna S Amberger
Online Mendelian Inheritance in Man (OMIM) at OMIM.org is the primary repository of comprehensive, curated information on genes and genetic phenotypes and the relationships between them. This unit provides an overview of the types of inform...
Identifying Significantly Impacted Pathways and Putative Mechanisms with iPathwayGuide [0.03%]
利用iPathwayGuide识别显著影响的途径和假设机制
Sidra Ahsan,Sorin Drăghici
Sidra Ahsan
iPathwayGuide is a gene expression analysis tool that provides biological context and inferences from data generated by high-throughput sequencing. iPathwayGuide utilizes a systems biology approach to identify significantly impacted signali...
Jian Wang,Yi Xiao
Jian Wang
This unit describes how to use 3dRNA to predict RNA 3-D structures from their sequences and secondary (2-D) structures, and how to use 3dRNAscore to evaluate the predicted structures. The predicted RNA 3-D structures can be used to predict ...
Sebastian Höhna,Michael J Landis,Tracy A Heath
Sebastian Höhna
Bayesian phylogenetic inference aims to estimate the evolutionary relationships among different lineages (species, populations, gene families, viral strains, etc.) in a model-based statistical framework that uses the likelihood function for...
Using FunSeq2 for Coding and Non-Coding Variant Annotation and Prioritization [0.03%]
用Funseq2进行编码和非编码变异的批注与优先级划分
Priyanka Dhingra,Yao Fu,Mark Gerstein et al.
Priyanka Dhingra et al.
The identification of non-coding drivers remains a challenge and bottleneck for the use of whole-genome sequencing in the clinic. FunSeq2 is a computational tool for annotation and prioritization of somatic mutations in coding and non-codin...
ascatNgs: Identifying Somatically Acquired Copy-Number Alterations from Whole-Genome Sequencing Data [0.03%]
基于全基因组测序数据识别体细胞拷贝数变异getAscatNGS
Keiran M Raine,Peter Van Loo,David C Wedge et al.
Keiran M Raine et al.
We have developed ascatNgs to aid researchers in carrying out Allele-Specific Copy number Analysis of Tumours (ASCAT). ASCAT is capable of detecting DNA copy number changes affecting a tumor genome when comparing to a matched normal sample....
Searching the Mouse Genome Informatics (MGI) Resources for Information on Mouse Biology from Genotype to Phenotype [0.03%]
利用基因型到表型的资讯检索Mouse Genome Informatics(MGI)资源以获取有关小鼠生物学的信息
David R Shaw
David R Shaw
The Mouse Genome Informatics (MGI) resource provides the research community with access to information on the genetics, genomics, and biology of the laboratory mouse. Core data in MGI include gene characterization and function, phenotype an...