Predicting the secondary structure common to two RNA sequences with Dynalign [0.03%]
利用Dynalign预测两个RNA序列共有的二级结构
David Mathews
David Mathews
Dynalign is a dynamic programming algorithm for the simultaneous prediction of the lowest-free-energy secondary structure common to two RNA sequences and the alignment of the two sequences. It has been shown that the average accuracy of sec...
RNAi: design and analysis [0.03%]
RNA干扰：设计与分析
Ravi Sachidanandam
Ravi Sachidanandam
RNAi is a novel genetic tool that is poised to revolutionize the study of genetics and gene networks. Use of this tool requires knowledge of the underlying mechanisms and application of this knowledge to the construction of a gene-silencing...
Ivo L Hofacker
Ivo L Hofacker
This Current Protocols in Bioinformatics unit documents how to use the Vienna RNA package for RNA secondary structure analysis. Possible tasks include structure prediction for single sequences, prediction of consensus structures, and sequen...
Searching the Mouse Genome Informatics (MGI) resources for information on mouse biology from genotype to phenotype [0.03%]
利用Mouse Genome Informatics (MGI)资源查询从基因型到表型的小鼠生物学信息
David Shaw
David Shaw
The Mouse Genome Informatics (MGI, http://www.informatics.jax.org/) resource provides the research community with access to information on the genetics, genomics, and biology of the laboratory mouse. Core data in MGI include gene characteri...
Robert M Peitzsch
Robert M Peitzsch
There are several different methodologies that can be used for designing a database schema; no one is the best for all occasions. This unit demonstrates two different techniques for designing relational tables and discusses when each should...
D Curtis Jamison
D Curtis Jamison
Relational databases provide the most common platform for storing data. The Structured Query Language (SQL) is a powerful tool for interacting with relational database systems. SQL enables the user to concoct complex and powerful queries in...
Gianni Cesareni,Manuela Helmer-Citterich
Gianni Cesareni
The Molecular Interactions Database (MINT) is a relational database designed to store information about protein interactions. Expert curators extract the relevant information from the scientific literature and deposit it in a computer reada...
Using DelPhi to compute electrostatic potentials and assess their contribution to interactions [0.03%]
用DelPhi计算电位和评估其在相互作用中的贡献
Assaf Oron,Haim Wolfson,Kannan Gunasekaran et al.
Assaf Oron et al.
There is a general agreement that electrostatic interactions play a significant role in the structure and function of biological molecules. However, obtaining quantitative estimation of the electrostatic energy requires computational models...
David F Green,Bruce Tidor
David F Green
Described here are several computational procedures for the analysis of electrostatic interactions in molecular complexes, all based on a continuum model of solvation. The first section describes how to compute the residual potential, a mea...
Shawn M Gomez
Shawn M Gomez
This unit offers a general overview of several techniques that have been developed for inferring functional and/or protein-protein interaction networks. The majority of these use whole-genome sequences as their primary input source of data....