Using the Gibbs motif sampler to find conserved domains in DNA and protein sequences [0.03%]
利用Gibbs motifsampler在DNA和蛋白质序列中寻找保守域
William Thompson,Lee Ann McCue,Charles E Lawrence
William Thompson
The Gibbs Motif Sampler (Gibbs) is a software package for discovering conserved elements in biopolymer sequences. This unit describes the basic operation of the Web-based interface to Gibbs, along with advanced examples of its use, and the ...
Deborah H Lundgren,David K Han,Jimmy K Eng
Deborah H Lundgren
SEQUEST is the most widely used software tool for identifying proteins in complex mixtures. It is a mature, robust program that identifies peptides directly from uninterpreted tandem mass spectra, thus making large-scale proteomic studies p...
Proteomics and the analysis of proteomic data: an overview of current protein-profiling technologies [0.03%]
蛋白质组学和蛋白组数据的分析：当前蛋白质谱技术概览
Erol E Gulcicek,Christopher M Colangelo,Walter McMurray et al.
Erol E Gulcicek et al.
In recent years, several proteomic methodologies have been developed that now make it possible to identify, characterize, and comparatively quantify the relative level of expression of hundreds of proteins that are coexpressed in a given ce...
Sam Griffiths-Jones
Sam Griffiths-Jones
Non-coding RNA (ncRNA) genes produce a functional RNA product, rather than a translated protein. The range and importance of such genes is only recently apparent, with known ncRNAs participating in a wide range of structural, regulatory, an...
Xiaoqiu Huang,Shiaw-Pyng Yang
Xiaoqiu Huang
This unit describes how to use the Parallel Contig Assembly Program (PCAP) to assemble the data produced by a whole-genome shotgun sequencing project. We present a basic protocol for using PCAP on a multiprocessor computer in a 300-Mb genom...
MultiPipMaker: comparative alignment server for multiple DNA sequences [0.03%]
多序列DNA比较对齐工具MultiPipMaker服务器
Laura Elnitski,Cathy Riemer,Richard Burhans et al.
Laura Elnitski et al.
The MultiPipMaker World Wide Web server (http://www.bx.psu.edu) provides a useful tool for aligning multiple sequences and visualizing regions of conservation between them. This unit describes the use of the MultiPipMaker server and gives a...
Kiyoko F Aoki,Minoru Kanehisa
Kiyoko F Aoki
KEGG (Kyoto Encyclopedia of Genes and Genomes) is a bioinformatics resource for understanding the functions and utilities of cells and organisms from both high-level and genomic perspectives. It is a self-sufficient, integrated resource con...
Using the Arabidopsis Information Resource (TAIR) to find information about Arabidopsis genes [0.03%]
利用拟南芥信息资源（TAIR）查找拟南芥基因的信息
Leonore Reiser,Seung Yon Rhee
Leonore Reiser
The Arabidopsis Information Resource (TAIR; http://www.arabidopsis.org) is a comprehensive Web resource of Arabidopsis biology for plant scientists. TAIR curates and integrates information about genes, proteins, gene expression, mutant phen...
Human mutation databases [0.03%]
人类突变数据库
Ourania Horaitis,Richard G H Cotton
Ourania Horaitis
The first part of this unit compares general and locus-specific mutation databases. The second section deals with submitting data. The third part provides guidance for accessing mutation data. The final section offers advice on database con...
Using relational databases for improved sequence similarity searching and large-scale genomic analyses [0.03%]
利用关系数据库改进序列相似性搜索和大规模基因组分析
Aaron J Mackey,William R Pearson
Aaron J Mackey
Relational databases are designed to integrate diverse types of information and manage large sets of search results, greatly simplifying genome-scale analyses. Relational databases are essential for management and analysis of large-scale se...