Gary D Stormo
Gary D Stormo
Homologous sequences usually have the same, or very similar, functions, so new sequences can be reliably assigned functions if homologous sequences with known functions can be identified. Homology is inferred based on sequence similarity, a...
Da Wei Huang,Brad T Sherman,Xin Zheng et al.
Da Wei Huang et al.
High-throughput genomics screening studies, such as microarray, proteomics, etc., often result in large, "interesting" gene lists, ranging in size from hundreds to thousands of genes. Given the challenges of functionally interpreting such l...
Searching Online Mendelian Inheritance in Man (OMIM) for information on genetic loci involved in human disease [0.03%]
在在线人类孟德尔遗传数据库（Online Mendelian Inheritance in Man, OMIM）中检索参与人类疾病基因位点信息的方法
Bhavesh Borate,Andreas D Baxevanis
Bhavesh Borate
Online Mendelian Inheritance in Man (OMIM) is a comprehensive compendium of information on human genes and genetic disorders, with a particular emphasis on the interplay between observed phenotypes and underlying genotypes. This unit focuse...
Andreas D Baxevanis
Andreas D Baxevanis
Biological databases play a central role in bioinformatics. They offer scientists the opportunity to access a wide variety of biologically relevant data, including the genomic sequences of an increasingly broad range of organisms. This unit...
Istvan Ladunga
Istvan Ladunga
The Basic Local Alignment Search Tool (BLAST) is a keystone of bioinformatics due to its performance and user-friendliness. Beginner and intermediate users will learn how to design and submit blastn and Megablast searches on the Web pages a...
Kirill Degtyarenko,Janna Hastings,Paula de Matos et al.
Kirill Degtyarenko et al.
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on "small" chemical compounds. This unit provides a detailed guide to browsing, searching, downloading, and programmatic access ...
Jens Reeder,Robert Giegerich
Jens Reeder
This unit shows how to use the RNAshapes package for the prediction of the secondary structure of a single RNA sequence using either minimum free energy methods or weighted ensemble information. It also includes a protocol for the consensus...
Ivo L Hofacker
Ivo L Hofacker
This unit documents how to use the Vienna RNA package for RNA secondary structure analysis. Possible tasks include structure prediction for single sequences, prediction of consensus structures, prediction of RNA-RNA interactions, and sequen...
Obtaining comparative genomic data with the VISTA family of computational tools [0.03%]
利用VISTA系列计算工具获取比较基因组数据
Igor Ratnere,Inna Dubchak
Igor Ratnere
Comparison of DNA sequences from different species is a fundamental method for identifying functional elements, such as exons or enhancers, as they tend to exhibit significant sequence similarity due to purifying selection. Availability of ...
Using RepeatMasker to identify repetitive elements in genomic sequences [0.03%]
利用RepeatMasker识别基因组序列中的重复元件
Maja Tarailo-Graovac,Nansheng Chen
Maja Tarailo-Graovac
RepeatMasker is a popular software tool widely used in computational genomics to identify, classify, and mask repetitive elements, including low-complexity sequences and interspersed repeats. RepeatMasker searches for repetitive sequence by...