Aaron R Quinlan
Aaron R Quinlan
Technological advances have enabled the use of DNA sequencing as a flexible tool to characterize genetic variation and to measure the activity of diverse cellular phenomena such as gene isoform expression and transcription factor binding. E...
MalaCards: A Comprehensive Automatically-Mined Database of Human Diseases [0.03%]
MalaCards：人类疾病的全面自动数据平台
Noa Rappaport,Michal Twik,Noam Nativ et al.
Noa Rappaport et al.
Systems medicine provides insights into mechanisms of human diseases, and expedites the development of better diagnostics and drugs. To facilitate such strategies, we initiated MalaCards, a compendium of human diseases and their annotations...
BreakDancer: Identification of Genomic Structural Variation from Paired-End Read Mapping [0.03%]
BreakDancer：从配对末端读段比对中识别基因组结构变异
Xian Fan,Travis E Abbott,David Larson et al.
Xian Fan et al.
The advent of the next-generation sequencing data has made it possible to cost-effectively detect and characterize genomic variation in human genomes. Structural variation, including deletion, duplication, insertion, inversion and transloca...
Metaproteomics: extracting and mining proteome information to characterize metabolic activities in microbial communities [0.03%]
元蛋白质组学：提取和挖掘微生物群落中代谢活动的蛋白质信息
Paul E Abraham,Richard J Giannone,Weili Xiong et al.
Paul E Abraham et al.
Contemporary microbial ecology studies usually employ one or more "omics" approaches to investigate the structure and function of microbial communities. Among these, metaproteomics aims to characterize the metabolic activities of the microb...
Using PeptideAtlas, SRMAtlas, and PASSEL: Comprehensive Resources for Discovery and Targeted Proteomics [0.03%]
利用肽图谱、SRM图谱和PASSEL：用于发现和靶向蛋白质组学的全面资源
Ulrike Kusebauch,Eric W Deutsch,David S Campbell et al.
Ulrike Kusebauch et al.
PeptideAtlas, SRMAtlas, and PASSEL are Web-accessible resources to support discovery and targeted proteomics research. PeptideAtlas is a multi-species compendium of shotgun proteomic data provided by the scientific community; SRMAtlas is a ...
Jerry D Holman,David L Tabb,Parag Mallick
Jerry D Holman
After raw data have been captured by mass spectrometers in biological LC-MS/MS experiments, they must be converted from vendor-specific binary files to open-format files for manipulation by most software. This protocol details the use of Pr...
David H Mathews
David H Mathews
RNAstructure is a user-friendly program for the prediction and analysis of RNA secondary structure. It is available as a Web server, as a program with a graphical user interface, or as a set of command-line tools. The programs are available...
Using the RNAstructure Software Package to Predict Conserved RNA Structures [0.03%]
使用RNAstructure软件预测保守的RNA结构
David H Mathews
David H Mathews
The structures of many non-coding RNA (ncRNA) are conserved by evolution to a greater extent than their sequences. By predicting the conserved structure of two or more homologous sequences, the accuracy of secondary structure prediction can...
William R Pearson
William R Pearson
Protein sequence similarity searching programs like BLASTP, SSEARCH (UNIT 3.10), and FASTA use scoring matrices that are designed to identify distant evolutionary relationships (BLOSUM62 for BLAST, BLOSUM50 for SEARCH and FASTA). Different ...
Lincoln Stein
Lincoln Stein
The essence of bioinformatics is dealing with large quantities of information. Whether it be sequencing data, microarray data files, mass spectrometric data (e.g., fingerprints), the catalog of strains arising from an insertional mutagenesi...