C/EBP-β/MeCP2/Wnt Axis Participates in the Testicular Injury in Rats Under Simulated Microgravity Conditions [0.03%]
C/EBP-β/MeCP2/Wnt信号轴参与模拟失重条件下大鼠睾丸损伤病理过程
Pan Ge,Si-Yu Wang,Xiang Zhang et al.
Pan Ge et al.
Background and objective: As space exploration advances, the effects of the microgravity environment on testicular injury and spermatogenic function in astronauts have attracted widespread attention, but the underlying me...
Circ_0070987 Promotes Pyroptosis of Ovarian Granulosa Cells in Polycystic Ovarian Syndrome Through the miR-139-5/CDH1 Axis [0.03%]
circ_0070987通过miR-139-5p/CDH1轴促进多囊卵巢综合征卵泡颗粒细胞焦亡
Rui Huang,Miao Gao
Rui Huang
PCOS refers to an endocrine and metabolic disorder that affects female individuals of reproductive age. Our study explores the potential mechanism of circ_0070987 on PCOS in regulating pyroptosis of ovarian GCs, providing new evidence for P...
Regulatory Interplay of p53, AMPK, and mTOR in Decidualization: Implications for Reproductive Competence and Cancer Biology [0.03%]
p53、AMPK和mTOR在蜕膜化的互作调控及其对生殖能力和肿瘤生物学的意义
Hiroshi Kobayashi,Hiroshi Shigetomi,Miki Nishio et al.
Hiroshi Kobayashi et al.
Construction and Validation of a Novel Prognostic Model Based on Cervical Cancer-Related Genes [0.03%]
基于宫颈癌相关基因的预后模型的构建与验证
Daoyang Zou,Xiuhong Wu,Xi Xin et al.
Daoyang Zou et al.
Background: Cervical cancer (CC) is the fourth most frequently diagnosed cancer and the fourth leading cause of cancer-related deaths in women worldwide, however, the treatment options for advanced CC are limited. Therefo...
Genome Editing for Fertility: Unlocking the Promise of CRISPR/Cas9 in Addressing Male Infertility - A Narrative Review [0.03%]
针对男性不育的基因编辑生育技术：CRISPR/Cas9的应用及展望——叙述性综述
Naina Kumar
Naina Kumar
Male infertility remains a significant global reproductive health challenge, frequently attributed to genetic mutations impairing spermatogenesis and sperm function. This narrative review aims to explore the genetic and molecular underpinni...
Integrated Transcriptomics and Single-Cell RNA Sequencing Analyses Reveal the Potential Role of Obesity-Related Genes in Polycystic Ovary Syndrome [0.03%]
整合转录组和单细胞RNA测序分析揭示肥胖相关基因在多囊卵巢综合征中的潜在作用
Xin Gong
Xin Gong
Obesity leads to menstrual dysfunction by impacting the "hypothalamic-pituitary-ovarian axis" in women, which can result in polycystic ovary syndrome (PCOS). The differentially expressed genes (DEGs) between the PCOS and control groups were...
Evaluating Dexamethasone as an Adjuvant in the Antagonist Protocol in PCOS Patients Undergoing IVF/ICSI: A Randomized Controlled Trial [0.03%]
评估地塞米松作为PCOS患者在接受IVF/ICSI时对抗剂方案的辅助用药：一项随机对照试验
Fahimeh Alizadeh,Malihe Amirian,Nayereh Khadem et al.
Fahimeh Alizadeh et al.
Beneficial Role of Resveratrol on Oxidative Stress in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial [0.03%]
白藜醇对多囊卵巢综合征女性氧化应激的有益作用：一项随机对照试验
Negar Ajabi Ardehjani,Marzieh Agha-Hosseini,Maryam Shabani Nashtaei et al.
Negar Ajabi Ardehjani et al.
Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder in women. Oxidative stress (OS) plays a pivotal role in the pathogenesis of PCOS. Resveratrol, as a natural polyphenol, has several beneficial therapeutic effects for w...
Liquiritigenin Restores Declined Oocyte Quality and Improves Embryo Development in Aged Mice [0.03%]
甘草素通过改善老化小鼠卵母细胞质量促进早期胚胎发育
Yelan Cai,Jiawei Ma,Haifeng Xu et al.
Yelan Cai et al.
Ovarian aging leads to a decline in oocyte quality and reduced reproductive potential, which is one of the main challenges faced by assisted reproductive technology (ART). Oxidative stress (OS) is a major contributor to this decline. In thi...
Maxim A Filatov,Iuliia P Baikova,Daria M Dolmatova
Maxim A Filatov
Ex utero embryo culture is one of the important tasks that has not been completely solved. In the first part of the current review, we focus on potential roles ex utero mammalian embryo culture could play, such as in infertility treatment o...