Circulating microRNAs as Potential Biomarkers for the Diagnosis of Endometrial Cancer: a Meta-Analysis [0.03%]
循环microRNA作为子宫内膜癌诊断潜在生物标志物的meta分析研究
Jie Gao,Ya-Zhou Fan,Shuai-Shuai Gao et al.
Jie Gao et al.
Endometrial cancer (EC) is the most common female genital tract malignancy worldwide. Many investigators have confirmed the possibility of using circulating miRNAs to diagnose EC; however, the results were inconsistent. Therefore, we perfor...
Updates on Molecular Targets and Epigenetic-Based Therapies for PCOS [0.03%]
多囊卵巢综合征的分子靶点和表观遗传学治疗的新进展
Viktor V Smirnov,Narasimha M Beeraka,Dmitry Yu Butko et al.
Viktor V Smirnov et al.
Polycystic ovarian syndrome (PCOS) can cause infertility in females due to hyperandrogenism and neuroendocrine abnormalities. The aim of this study is to decipher the impact of endocrine variables, hyperandogenism, insulin resistance, oxida...
The Association Between Season and Hypertensive Disorders in Pregnancy: a Systematic Review and Meta-analysis [0.03%]
季节变化与孕期高血压的关系：系统回顾和荟萃分析
Lingyun Liao,Xiaohong Wei,Min Liu et al.
Lingyun Liao et al.
There is increasing and inconsistent evidence of a relationship between hypertensive disorders in pregnancy (HDPs) and season of delivery or conception. In this systematic review and meta-analysis, we assessed the association between season...
Whither Reproduction? How to Insert Science into the Debate About How Societies Create Families [0.03%]
走向生育：如何在关于社会如何创造家庭的辩论中加入科学议题？
Nanette Santoro
Nanette Santoro
It sometimes appears that science is moving in one direction and society is moving in another. When we act as physicians, we are compelled to care for the patient in front of us in a one-on-one relationship. When we act as reproductive scie...
Targeted Deletion of Mitofusin 1 and Mitofusin 2 Causes Female Infertility and Loss of Follicular Reserve [0.03%]
线粒体融合蛋白1和2缺失导致雌性不孕及卵泡储备耗竭
Mauro Cozzolino,Yagmur Ergun,Emre Seli
Mauro Cozzolino
Mitochondria are dynamic organelles that regulate their size, shape, and morphology through mechanisms called fusion and fission, to continually adapt themselves to their bioenergetic environment. These mechanisms play a critical role to ma...
Female Infertility Is Associated with an Altered Expression Profile of Different Members of the Tachykinin Family in Human Granulosa Cells [0.03%]
女性不孕与人类颗粒细胞中不同缓激肽家族成员表达谱的改变有关
Víctor Blasco,Francisco M Pinto,Ainhoa Fernández-Atucha et al.
Víctor Blasco et al.
Neurokinin B (NKB) and its cognate receptor, NK3R, play a key role in the regulation of reproduction. NKB belongs to the family of tachykinins, which also includes substance P and neurokinin A, both encoded by the by the gene TAC1, and hemo...
Maternal Underweight and Obesity Are Associated with Placental Pathologies in Human Pregnancy [0.03%]
母体体重过轻和超重与人类妊娠胎盘病理有关
Hailey Scott,David Grynspan,Laura N Anderson et al.
Hailey Scott et al.
Maternal underweight and obesity are prevalent conditions, associated with chronic, low-grade inflammation, poor fetal development, and long-term adverse outcomes for the child. The placenta senses and adapts to the pregnancy environment in...
In Vivo Genome-Wide PGR Binding in Pregnant Human Myometrium Identifies Potential Regulators of Labor [0.03%]
人孕期子宫蜕膜中PGR结合的全基因组研究鉴定出可能与分娩相关的潜在调节因子
Ariel J Dotts,Derek Reiman,Ping Yin et al.
Ariel J Dotts et al.
The alterations in myometrial biology during labor are not well understood. The myometrium is the contractile portion of the uterus and contributes to labor, a process that may be regulated by the steroid hormone progesterone. Thus, human m...
Reduction of SLC7A11 and GPX4 Contributing to Ferroptosis in Sperm from Asthenozoospermia Individuals [0.03%]
SLC7A11和GPX4表达降低参与弱精症患者精子铁死亡发生发展
Xiaoling Hao,Hong Wang,Fang Cui et al.
Xiaoling Hao et al.
Ferroptosis is a newly defined form of regulated cell death, which is involved in various pathophysiological conditions. However, the role of ferroptosis in male infertility remains unclear. In this study, 42 asthenozoospermic and 45 normoz...
miRNA Profiling of Major Testicular Germ Cells Identifies Stage-Specific Regulators of Spermatogenesis [0.03%]
雄性生殖细胞的微小核糖核酸谱系鉴定出精子发生过程中不同阶段的特异性调节物
Shruti Sethi,Poonam Mehta,Aastha Pandey et al.
Shruti Sethi et al.
Spermatogenesis is tightly controlled at transcriptional, post-transcriptional, and epigenetic levels by various regulators, including miRNAs. This study deals with the identification of miRNAs critical to the three important stages of germ...