Protective Effect of Glutathione Supplementation On Mouse Ovarian Tissue Vitrification and Autologous Transplantation [0.03%]
谷胱甘肽对小鼠卵巢组织玻璃化冷冻及自体移植的保护作用
Mengxuan Jia,Rongrong Zhang,Xue Ma et al.
Mengxuan Jia et al.
Ovarian tissue vitrification is a key strategy for fertility preservation, but remains hindered by oxidative damage and compromised tissue viability. This study evaluates the cytoprotective effects of glutathione (GSH) supplementation durin...
Novel DNAH17 Splice-Site Mutations Truncating the AAA6 Domain Cause Asthenozoospermia with MMAF [0.03%]
DNAH17剪切位点新突变导致AAAdomain截短并与少弱精子症相关
Leilei Feng,Feng Wan,Chenchen Cui et al.
Leilei Feng et al.
To investigate the pathogenicity of splice-site variants in DNAH17, and analyze their impact on sperm morphology and motility, we employed whole-exome sequencing (WES) and Sanger sequencing to identify and validate candidate variants. Compu...
An Insight into Experimental Animal Models for Polycystic Ovarian Syndrome and Associated Disorders [0.03%]
多囊卵巢综合征及相关疾病的实验动物模型研究进展
Surabhi B Patil,Yogesh A Kulkarni
Surabhi B Patil
Polycystic Ovary Syndrome (PCOS) is a complex endocrine and metabolic condition that affects around 8-13% of women worldwide. PCOS is defined by hyperandrogenism, insulin resistance, and many reproductive irregularities, providing significa...
The Effect of Ferulic Acid on the Akt-GSK3β Signaling Pathway, Neuroinflammation, Oxidative Stress, and Cortical Damage in the Fetal Brain with Uteroplacental Insufficiency [0.03%]
富马酸对子宫胎盘血液供应不足的胎儿大脑中Akt-GSK3β信号通路、神经炎症、氧化应激和皮质损伤的影响
Habibollah Khodabandeh,Mohammad Amin Edalatmanesh,Mohsen Forouzanfar
Habibollah Khodabandeh
Uteroplacental insufficiency (UPI) disrupts fetal brain development and induces oxidative damage. This study evaluates the neuroprotective effects of ferulic acid (FA) on oxidative stress biomarkers, neuroinflammation, the Akt/GSK-3β signa...
Multilevel Transcriptomic Association Analysis Reveals Key Genes and Potential Mechanisms in Endometrial, Ovarian, and Cervical Cancers [0.03%]
多层次转录组关联分析揭示子宫内膜癌、卵巢癌和宫颈癌的关键基因及潜在机制
Liang Liu,Xinghao Zhao
Liang Liu
Objective: This study aims to investigate the genetic associations of endometrial cancer (EC), ovarian cancer (OC), and cervical cancer (CC), identify potential key genes using multiple genomic analysis approaches, and an...
Polyherbal Therapeutics Mitigate CCl4-Induced Testicular Toxicity through Modulation of SHBG, AKT1, and AR Pathways: An Integrated In Vitro, In Vivo, and In Silico Approach [0.03%]
多药治疗通过调节SHBG，AKT1和AR途径减轻CCl4诱导的睾丸毒性：集成的体内，体外和计算机模拟方法研究
Shoukat Hussain,Alia Javed,Dur EMaknoon Razia et al.
Shoukat Hussain et al.
Male infertility accounts for nearly half of all infertility cases globally, often resulting from oxidative stress and hormonal dysregulation. Conventional treatments offer limited efficacy, prompting interest in multi-target botanical ther...
Identification of Gestation-Specific Patterns of Physiological, Protein and Cell-Free RNA Injury Markers in a Sheep Model of Regulable Preterm Fetal Hypoxia [0.03%]
恒定调节的早期羊胎前循环缺氧模型中鉴定妊娠特异性生理、蛋白和无细胞RNA损伤标志物模式
Haruo Usuda,Hideyuki Ikeda,Shimpei Watanabe et al.
Haruo Usuda et al.
Fetal hypoxia remains a major unresolved clinical challenge. Using artificial placenta (AP) technology, we established a standardized model of progressive hypoxia that induces brain injury in fetal sheep. To support the development of new a...
The Effect of Prenatal Dexamethasone Exposure on Placental Morphology and Function at Different Stages, Doses, and Courses In Mice [0.03%]
孕鼠不同孕期、不同剂量和疗程地塞米松暴露对胎盘形态及功能的影响
Hui Feng,Yuhong Lin,Xiaoqi Zhao et al.
Hui Feng et al.
The "double-edged sword" effect of dexamethasone on fetal development has attracted significant attention. Currently, the "one-size-fits-all" prenatal corticosteroid regimen fails to confer uniform benefits to all pregnant women and fetuses...
Knockdown of CTMP Enhances Progesterone Sensitivity in Endometrial Cancer by Inhibiting the PI3K/AKT Signaling Pathway [0.03%]
CTMP敲低通过抑制PI3K/AKT信号通路增强子宫内膜癌细胞孕酮敏感性
Xinyu Yu,Hongxin Xing,Kaiyue Shang et al.
Xinyu Yu et al.
Progesterone resistance is a key factor in the failure of conservative treatment in young endometrial cancer patients, and there is no effective method to predict and reverse progesterone resistance. CTMP is known to be involved in the deve...
LncPrep + 96 kb Inhibits the Secretion of Inhibin B in Ovarian Granulosa Cells Through Regulating Endothelial Differentiation-Associated Factor 1 [0.03%]
长链非编码RNA LncPrep通过调控血管生成素分化相关因子1抑制卵巢颗粒细胞INHB的分泌
Hongdan Zhang,Jianwei Liu,Canglang Mou et al.
Hongdan Zhang et al.
Abnormal levels of Inhibin B (INH-B), a major regulator of ovarian activity, are closely linked to the development and prognosis of several ovarian disorders. Understanding the molecular mechanisms governing its regulation in granulosa cell...