Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein [0.03%]
斑马鱼致病蛋白突变体的转录组分析支持细胞prion蛋白跨物种保守功能
Niall Mungo Pollock,Patricia Leighton,Gavin Neil et al.
Niall Mungo Pollock et al.
Cellular Prion Protein (PrPC) is a well-studied protein as the substrate for various progressive untreatable neurodegenerative diseases. Normal functions of PrPC are poorly understood, though recent proteomic and transcriptomic approaches h...
Creutzfeldt-Jakob disease in pregnancy: the use of modified RT-QuIC to determine infectivity in placental tissues [0.03%]
妊娠期克雅氏病：使用改良的RT-QuIC测定胎盘组织中的感染性
Collin C Luk,Candace K Mathiason,Christina D Orrù et al.
Collin C Luk et al.
Sporadic Creutzfeldt-Jakob Disease (sCJD) rarely affects women of childbearing age. There is currently no evidence of vertical transmission. Given the biosafety implications of performing Caesarean sections (C-section) in these patients, we...
Case Reports
Prion. 2021 Dec;15(1):107-111. DOI:10.1080/19336896.2021.1933872 2021
Jesús De Pedro-Cuesta,Javier Almazán-Isla,Laura Tejedor-Romero et al.
Jesús De Pedro-Cuesta et al.
In Spain, human transmissible spongiform encephalopathies (TSEs) have been undergoing continuous surveillance for over 25 years. In 1995, the system was launched as an EU Concerted Action, with EU surveillance network procedures being incor...
Long-term preservation of pharyngeal swallowing function in MM2-cortical-type sporadic Creutzfeldt-Jakob disease [0.03%]
散发性Creutzfeldt-Jakob病MM2皮质型长期保有吞咽功能的1例报告
Yuichi Hayashi,Kenjiro Kunieda,Takuya Kudo et al.
Yuichi Hayashi et al.
Swallowing function in long-term survivors of Creutzfeldt-Jakob disease (CJD) has not been elucidated. Herein, we report a patient with MM2-cortical-type sporadic CJD (MM2C-type sCJD) with long-term preservation of pharyngeal swallowing fun...
Case Reports
Prion. 2021 Dec;15(1):82-86. DOI:10.1080/19336896.2021.1930851 2021
Ilia V Baskakov
Ilia V Baskakov
Transformation of astrocytes into reactive states is considered one of the major pathological hallmarks of prion and other neurodegenerative diseases. Recent years witnessed a growing appreciation of the view that reactive astrocytes are in...
Development of molecular tools for diagnosis of Alzheimer's disease that are based on detection of amyloidogenic proteins [0.03%]
基于淀粉样蛋白致病蛋白检测的阿尔茨海默病诊断分子工具的研发
Konstantin Y Kulichikhin,Sergei A Fedotov,Maria S Rubel et al.
Konstantin Y Kulichikhin et al.
Alzheimer's disease (AD) is the most common form of dementia that usually occurs among older people. AD results from neuronal degeneration that leads to the cognitive impairment and death. AD is incurable, typically develops over the course...
Hypothesis: AA amyloidosis is a factor causing systemic complications after coronavirus disease [0.03%]
假设：AA淀粉样变性是新型冠状病毒病后导致全身并发症的一个因素
Alexey P Galkin
Alexey P Galkin
The severe course of COVID-19 causes systemic chronic inflammation and thrombosis in a wide variety of organs and tissues. The nature of these inflammations remains a mystery, although they are known to occur against the background of a hig...
Monomeric a-synuclein (aS) inhibits amyloidogenesis of human prion protein (hPrP) by forming a stable aS-hPrP hetero-dimer [0.03%]
单体α-突触核蛋白通过形成稳定的α-突触核蛋白人朊病毒蛋白异二聚体来抑制人朊病毒蛋白的淀粉样变性
Satoshi Yamashita,Yuji O Kamatari,Ryo Honda et al.
Satoshi Yamashita et al.
Intermolecular interaction between hPrP and αS was investigated using high-speed atomic force microscopy, dynamic light scattering, and nuclear magnetic resonance. We found that hPrP spontaneously gathered and naturally formed oligomers. U...
Characterization of the prion protein gene in axis deer (Axis axis) and implications for susceptibility to chronic wasting disease [0.03%]
轴鹿朊病毒基因的特征及对慢性消耗病易感性的启示
Matthew J Buchholz,Emily A Wright,Blake A Grisham et al.
Matthew J Buchholz et al.
Axis deer (Axis axis) occur both in captivity and free-ranging populations in portions of North America, but to-date, no data exist pertaining to the species' susceptibility to CWD. We sequenced the prion protein gene (PRNP) from axis deer....
STXBP1 forms amyloid-like aggregates in rat brain and demonstrates amyloid properties in bacterial expression system [0.03%]
STXBP1在大鼠脑中形成类似淀粉样蛋白的聚集物并在细菌表达系统中表现出淀粉样蛋白特性
A V Chirinskaite,V A Siniukova,M E Velizhanina et al.
A V Chirinskaite et al.
Amyloids are the fibrillar protein aggregates with cross-β structure. Traditionally amyloids were associated with pathology, however, nowadays more data is emerging about functional amyloids playing essential roles in cellular processes. W...