Charles R Schutt,Jason C Bartz
Charles R Schutt
Co-inoculation of prion strains into the same host can result in interference, where replication of one strain hinders the ability of another strain to cause disease. The drowsy (DY) strain of hamster-adapted transmissible mink encephalopat...
Anti-bovine prion protein RNA aptamer containing tandem GGA repeat interacts both with recombinant bovine prion protein and its beta isoform with high affinity [0.03%]
含串联GGA重复序列的抗牛朊蛋白RNA适配体能以高亲和力与重组牛朊蛋白及其β亚型同时结合
Kazuyoshi Murakami,Fumiko Nishikawa,Ken Noda et al.
Kazuyoshi Murakami et al.
In order to obtain RNA aptamers against bovine prion protein (bPrP), we carried out in vitro selection from RNA pools containing a 55-nucleotide randomized region to target recombinant bPrP. Most of obtained aptamers contained conserved GGA...
Comparative Study
Prion. 2008 Apr-Jun;2(2):73-80. DOI:10.4161/pri.2.2.7024 2008
Kay C Kunes,Scott C Clark,Daniel L Cox et al.
Kay C Kunes et al.
We propose models for in vitro grown mammalian prion protein fibrils based upon left handed beta helices formed both from the N-terminal and C-terminal regions of the proteinase resistant infectious prion core. The C-terminal threading onto...
Amyloid-like properties of Saccharomyces cerevisiae cell wall glucantransferase Bgl2p: prediction and experimental evidences [0.03%]
葡萄糖转移酶Bgl2p的淀粉样特性：预测和实验依据
Tatyana S Kalebina,Tatyana A Plotnikova,Anton A Gorkovskii et al.
Tatyana S Kalebina et al.
Glucantransferase Bgl2p is a major conserved cell wall constituent described for a wide range of yeast species. In the baker's yeast Saccharomyces cerevisiae it is the only non-covalently bound cell wall protein that cannot be released from...
Cellular prion protein null mice display normal AMPA receptor mediated long term depression [0.03%]
无细胞形式的朊病毒蛋白的小鼠显示正常的AMPA受体介导的长期压抑现象
Houman Khosravani,Yunfeng Zhang,Gerald W Zamponi
Houman Khosravani
Cellular prion protein (PrP(C)) appears to be involved in numerous physiological processes. We have recently shown a novel modulation of NMDA receptors by PrP(C) that results in neuroprotection via silencing of NMDA receptors containing NR2...
Mariana P B Gomes,Yraima Cordeiro,Jerson L Silva
Mariana P B Gomes
In the past decade, the interaction between prions and nucleic acids has garnered significant attention from the scientific community. for many years, the participation of RNA and/or DNA in prion pathology has been largely ruled out by the ...
Eva Birkmann,Detlev Riesner
Eva Birkmann
The prion infection is a conversion of host encoded prion protein (PrP) from its cellular isoform PrP(C) into the pathological and infectious isoform PrP(Sc); the conversion process was investigated by in vitro studies using recombinant and...