H-type bovine spongiform encephalopathy: complex molecular features and similarities with human prion diseases [0.03%]
H型牛海绵脑病：复杂的分子特征及其与人类朊病毒疾病的相似性
Anne-Gaëlle Biacabe,Jorg G Jacobs,Anna Bencsik et al.
Anne-Gaëlle Biacabe et al.
We previously reported that some cattle affected by bovine spongiform encephalopathy (BSE) showed distinct molecular features of the protease-resistant prion protein (PrP(res)) in Western blot, with a 1-2 kDa higher apparent molecular mass ...
Janine Beisson
Janine Beisson
This review will first recall the phenomena of "cortical inheritance" observed and genetically demonstrated in Paramecium 40 years ago, and later in other ciliates (Tetrahymena, Oxytricha, Paraurostyla), and will analyze the deduced concept...
Direct detection of disease associated prions in brain and lymphoid tissue using antibodies recognizing the extreme N terminus of PrPC [0.03%]
利用识别PrPC极端N末端的抗体直接检测脑和淋巴组织中的与疾病相关的prions
Geoff Barnard,Lee Hopkins,Sowmiya Moorthie et al.
Geoff Barnard et al.
A simple diagnostic test is described for the detection of TSE in bovine, ovine and human brain and lymphoid tissue that obviates the use of proteinase K as a discriminating reagent. The immunoassay utilises high affinity anti-peptide antib...
Ken Sasaki,Jyoti Gaikwad,Shuhei Hashiguchi et al.
Ken Sasaki et al.
The structure and the dissociation reaction of oligomers Pr(Poligo) from reduced human prion huPrP(C)(23-231) have been studied by (1)H-NMR and tryptophan fluorescence spectroscopy at varying pressure, along with circular dichroism and atom...
Antagonistic roles of the N-terminal domain of prion protein to doppel [0.03%]
朊病毒蛋白N端结构域与Dpl的作用竞争性研究
Suehiro Sakaguchi
Suehiro Sakaguchi
Prion protein (PrP)-like molecule, doppel (Dpl), is neurotoxic in mice, causing Purkinje cell degeneration. In contrast, PrP antagonizes Dpl in trans, rescuing mice from Purkinje cell death. We have previously shown that PrP with deletion o...
Roma N Rambaran,Louise C Serpell
Roma N Rambaran
Amyloid refers to the abnormal fibrous, extracellular, proteinaceous deposits found in organs and tissues. Amyloid is insoluble and is structurally dominated by beta-sheet structure. Unlike other fibrous proteins it does not commonly have a...
Biological and biochemical characterization of L-type-like bovine spongiform encephalopathy (BSE) detected in Japanese black beef cattle [0.03%]
日本黑牛肉牛中发现的类似典型型牛海绵状脑病(BSE)L类株的生物学和生化特征分析
Kentaro Masujin,Yujing Shu,Yoshio Yamakawa et al.
Kentaro Masujin et al.
A case of L-type-like atypical bovine spongiform encephalopathy was detected in 14-year-old Japanese black beef cattle (BSE/JP24). To clarify the biological and biochemical properties of the prion in BSE/JP24, we performed a transmission st...
The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme: a biological perspective [0.03%]
淀粉样蛋白肽底物与胰岛素降解酶的不可逆结合：生物学视角分析
Matías B de Tullio,Laura Morelli,Eduardo M Castaño
Matías B de Tullio
Insulin-degrading enzyme (IDE) is a conserved Zn(2+)metalloendopeptidase involved in insulin degradation and in the maintenance of brain steady-state levels of amyloid beta peptide (Abeta) of Alzheimer's disease (AD). Our recent demonstrati...
Curli provide the template for understanding controlled amyloid propagation [0.03%]
卷曲发状菌毛提供了一种理解受控淀粉样蛋白传播的模式
Xuan Wang,Matthew R Chapman
Xuan Wang
The uncontrolled formation of amyloid fibers is the hallmark of more than twenty human diseases. In contrast to disease-associated amyloids, which are the products of protein misfolding, E. coli assembles functional amyloid fibers called cu...
Insights into intragenic and extragenic effectors of prion propagation using chimeric prion proteins [0.03%]
利用嵌合朊病毒蛋白研究朊病毒传播的基因内和基因间的效应因素
Heather L True,Tejas Kalastavadi,Elizabeth M H Tank
Heather L True
The study of fungal prion proteins affords remarkable opportunities to elucidate both intragenic and extragenic effectors of prion propagation. The yeast prion protein Sup35 and the self-perpetuating [PSI+] prion state is one of the best ch...