Apoptosis versus cell differentiation: role of heat shock proteins HSP90, HSP70 and HSP27 [0.03%]
细胞凋亡与细胞分化：热休克蛋白HSP90、HSP70和HSP27的作用
David Lanneau,Aurelie de Thonel,Sebastien Maurel et al.
David Lanneau et al.
Heat shock proteins HSP27, HSP70 and HSP90 are molecular chaperones whose expression is increased after many different types of stress. They have a protective function helping the cell to cope with lethal conditions. The cytoprotective func...
Prion and nonprion amyloids: a comparison inspired by the yeast Sup35 protein [0.03%]
以芽殖酵母Sup35蛋白为借鉴的朊病毒与非朊病毒淀粉样蛋白的比较
Vitaly V Kushnirov,Aleksandra B Vishnevskaya,Ilya M Alexandrov et al.
Vitaly V Kushnirov et al.
Yeast prion determinants are related to polymerization of some proteins into amyloid-like fibers. The [PSI(+)] determinant reflects polymerization of the Sup35 protein. Fragmentation of prion polymers by the Hsp104 chaperone represents a ke...
Prion stability [0.03%]
朊病毒的稳定性
Brian S Cox,Lee J Byrne,Mick F Tuite
Brian S Cox
The rate of spontaneous change from psi(-) to the psi(+) condition, determined in yeast by states of the Sup35p protein, is briefly discussed together with the conditions necessary for such change to occur. Conditions that promote and which...
Prion-dependent lethality of sup45 mutants in Saccharomyces cerevisiae [0.03%]
酿酒酵母中SUP45突变体的朊病毒依赖型致死性
Denis Kiktev,Sergey Inge Vechtomov,Galina Zhouravleva
Denis Kiktev
In yeast Saccharomyces cerevisiae translation termination factors eRF1 (Sup45) and eRF3 (Sup35) are encoded by the essential genes SUP45 and SUP35 respectively. Heritable aggregation of Sup35 results in formation of the yeast prion [PSI(+)]...
Prion sequence polymorphisms and chronic wasting disease resistance in Illinois white-tailed deer (Odocoileus virginianus) [0.03%]
白尾鹿的素蛋白序列多态性和慢性消耗病抗性研究
Amy C Kelly,Nohra E Mateus-Pinilla,Jay Diffendorfer et al.
Amy C Kelly et al.
Nucleic acid sequences of the prion gene (PRNP) were examined and genotypes compiled for 76 white-tailed deer from northern Illinois, which previously tested positive for chronic wasting disease (CWD), and 120 negative animals selected to c...
Prion-prion interactions [0.03%]
朊病毒间的相互作用
Irina L Derkatch,Susan W Liebman
Irina L Derkatch
The term prion has been used to describe self-replicating protein conformations that can convert other protein molecules of the same primary structure into its prion conformation. Several different proteins have now been found to exist as p...
Self assembly of short aromatic peptides into amyloid fibrils and related nanostructures [0.03%]
短芳香肽自组装形成淀粉样纤维及相关纳米结构
Ehud Gazit
Ehud Gazit
The formation of amyloid fibrils is the hallmark of more than twenty human disorders of unrelated etiology. In all these cases, ordered fibrillar protein assemblies with a diameter of 7-10 nm are being observed. In spite of the great clinic...
Yury O Chernoff
Yury O Chernoff
Editorial
Prion. 2007 Apr-Jun;1(2):81-2. DOI:10.4161/pri.1.2.4667 2007
Yury O Chernoff
Yury O Chernoff
Editorial
Prion. 2007 Jan-Mar;1(1):1-2. DOI:10.4161/pri.1.1.4110 2007
Didier Belorgey,Peter Hägglöf,Susanna Karlsson-Li et al.
Didier Belorgey et al.
The serpins are the largest superfamily of protease inhibitors. They are found in almost all branches of life including viruses, prokaryotes and eukaryotes. They inhibit their target protease by a unique mechanism that involves a large conf...