Detection of two dissimilar chronic wasting disease isolates in two captive Rocky Mountain elk (Cervus canadensis) herds [0.03%]
在两支人工饲养的落基山麋鹿(Cervus canadensis)种群中检测到两种不同类型的慢性消耗病毒株
Tracy A Nichols,Eric M Nicholson,Yihui Liu et al.
Tracy A Nichols et al.
Chronic wasting disease (CWD) continues to spread in both wild and captive cervid herds in North America and has now been identified in wild reindeer and moose in Norway, Finland and Sweden. There is limited knowledge about the variety and ...
The role of microglia in prion diseases and possible therapeutic targets: a literature review [0.03%]
小胶质细胞在朊病毒疾病中的作用及其可能的治疗靶点：文献回顾
Ananda Sampaio Lamenha Falcão de Melo,Juliana Louise Dias Lima,Maria Carolina Silva Malta et al.
Ananda Sampaio Lamenha Falcão de Melo et al.
Creutzfeldt-Jakob disease (CJD) is a rare and fatal condition that leads to progressive neurodegeneration due to gliosis, vacuolation of central nervous system tissue, and loss of neurons. Microglia play a crucial role in maintaining Centra...
Prion protein polymorphisms in Michigan white-tailed deer (Odocoileus virginianus) [0.03%]
密歇根白尾鹿(Odocoileus virginianus)中的prion蛋白多态性
Caitlin N Ott-Conn,Julie A Blanchong,Wes A Larson
Caitlin N Ott-Conn
Chronic Wasting Disease (CWD), a well-described transmissible spongiform encephalopathy of the Cervidae family, is associated with the aggregation of an abnormal isoform (PrPCWD) of the naturally occurring host prion protein (PrPC). Variati...
Epitope-specific anti-PrP antibody toxicity: a comparative in-silico study of human and mouse prion proteins [0.03%]
抗原表位特异性抗PrP抗体毒性：人和鼠朊蛋白的比较性计算机模拟研究
Utpal Kumar Adhikari,Mourad Tayebi
Utpal Kumar Adhikari
Despite having therapeutic potential, anti-PrP antibodies caused a major controversy due to their neurotoxic effects. For instance, treating mice with ICSM antibodies delayed prion disease onset, but both were found to be either toxic or in...
Bin Chen,Shan Zhang,Ying Xiao et al.
Bin Chen et al.
We report a case of genetic Creutzfeldt-Jakob disease (gCJD), which has a clinical phenotype that is highly similar to Fatal Family Insomnia (FFI) and has a triad of Wernicke-Korsakoff syndrome (WKs) at the developmental stage of the diseas...
Case Reports
Prion. 2021 Dec;15(1):177-182. DOI:10.1080/19336896.2021.1968291 2021
Decoding the role of coiled-coil motifs in human prion-like proteins [0.03%]
解码盘状卷曲亮氨酸拉链在人类prion样蛋白中的作用
Molood Behbahanipour,Javier García-Pardo,Salvador Ventura
Molood Behbahanipour
Prions are self-propagating proteins that cause fatal neurodegenerative diseases in humans. However, increasing evidence suggests that eukaryotic cells exploit prion conformational conversion for functional purposes. A recent study delineat...
Differential astrocyte and oligodendrocyte vulnerability in murine Creutzfeldt-Jakob disease [0.03%]
小鼠克雅病中星形胶质细胞和少突胶质细胞的差异脆弱性
Pol Andrés-Benito,Margarita Carmona,Jean Yves Douet et al.
Pol Andrés-Benito et al.
Glial vulnerability to prions is assessed in murine Creutzfeldt-Jakob disease (CJD) using the tg340 mouse line expressing four-fold human PrP M129 levels on a mouse PrP null background at different days following intracerebral inoculation o...
Suman Chaudhary,Ajay Ashok,Aaron S Wise et al.
Suman Chaudhary et al.
Accumulation of redox-active iron in human sporadic Creutzfeldt-Jakob disease (sCJD) brain tissue and scrapie-infected mouse brains has been demonstrated previously. Here, we explored whether upregulation of local hepcidin secreted within t...
A Chinese patient with the clinical features of Parkinson's disease contains a single copy of octarepeat deletion in PRNP case report [0.03%]
一例携带PRNP八肽重复低拷贝基因的帕金森病患者临床报道
Qi Shi,Xiao-Jing Shen,Li-Ping Gao et al.
Qi Shi et al.
Insertion or deletion of single copy of octapeptide repeat (OR) in human PrP protein are considered as polymorphism, while of insertions of more numbers of OR and deletion of two copies of OR are associated with genetic prion diseases.Here,...
Case Reports
Prion. 2021 Dec;15(1):121-125. DOI:10.1080/19336896.2021.1946376 2021
PART and ARTAG tauopathies at a relatively young age as a concomitant finding in sporadic Creutzfeldt-Jakob disease [0.03%]
散发性克雅病患者的PART和ARTAG型tau蛋白opathy病理改变
Kateřina Menšíková,Radoslav Matěj,Eva Parobková et al.
Kateřina Menšíková et al.
Interactions between prion protein (PrP) and tau protein have long been discussed, especially in relation to the pathogenesis of neurodegenerative diseases. The presence of tauopathy in the genetic forms of Creutzfeldt-Jakob disease (CJD) b...