Daniel W Summers,Peter M Douglas,Douglas M Cyr
Daniel W Summers
Molecular chaperones regulate essential steps in the propagation of yeast prions. Yeast prions possess domains enriched in glutamines and asparagines that act as templates to drive the assembly of native proteins into beta-sheet-rich, amylo...
Comparative prion disease gene expression profiling using the prion disease mimetic, cuprizone [0.03%]
使用比美剂杯rizone进行病原蛋白疾病基因表达轮廓的比较分析
Laura R Moody,Allen J Herbst,Han Sang Yoo et al.
Laura R Moody et al.
Identification of genes expressed in response to prion infection may elucidate biomarkers for disease, identify factors involved in agent replication, mechanisms of neuropathology and therapeutic targets. Although several groups have sought...
Karine Gousset,Chiara Zurzolo
Karine Gousset
The discovery of tunnelling nanotubes (TNTs) and their proposed role in long intercellular transport of organelles, bacteria and viruses have led us to examine their potential role during prion spreading. We have recently shown that these m...
Yukiko M Yamashita
Yukiko M Yamashita
Asymmetric stem cell division is a mechanism widely employed by the cell to maintain tissue homeostasis, resulting in the production of one stem cell and one differentiating cell. However, asymmetric cell division is not limited to stem cel...
Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding [0.03%]
二氧孢素A可能是一种治疗蛋白数折变性神经退行性疾病的新药物
Wendy Noble,Claire J Garwood,Diane P Hanger
Wendy Noble
Many neurodegenerative disorders share common features including the accumulation of aggregated misfolded proteins, neuroinflammation and the induction of apoptosis. While the contributions of each of these individual elements to neuronal d...
Bess Frost,Marc I Diamond
Bess Frost
The aggregation of a soluble protein into insoluble, beta-sheet rich amyloid fibrils is a defining characteristic of many neurodegenerative diseases, including prion disorders. The prion protein has so far been considered unique because of ...
Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways [0.03%]
分子伴侣通过差异调节蛋白聚集途径对抗蛋白质毒性作用
Peter M Douglas,Daniel W Summers,Douglas M Cyr
Peter M Douglas
The self-association of misfolded or damaged proteins into ordered amyloid-like aggregates characterizes numerous neurodegenerative disorders. Insoluble amyloid plaques are diagnostic of many disease states. Yet soluble, oligomeric intermed...
Matthew F Calabrese,Andrew D Miranker
Matthew F Calabrese
Beta-2 microglobulin (beta2m) is the protein responsible for amyloid deposition in Dialysis-Related Amyloidosis (DRA). Aggregation can be induced by various solution conditions including exposure to divalent metal, incubation at acidic pH, ...
James A Huntington,Timothy J Sendall,Masayuki Yamasaki
James A Huntington
We recently solved the crystallographic structure of a dimeric form of the serpin antithrombin which has fundamentally changed the way we think about serpin polymerization. Like for other diseases that have protein deposition as a hallmark,...
Dynamic properties of pH-dependent structural organization of the amyloidogenic beta-protein (1-40) [0.03%]
PH值依赖的淀粉样β蛋白（1-40）结构组织的动力学性质
Alexander Rubinstein,Yuri L Lyubchenko,Simon Sherman
Alexander Rubinstein
The structural organization of the amyloidogenic beta-protein containing 40 amino acid residues (Abeta40) was studied by the high temperature molecular dynamics simulations in the acidic (pH approximately 3) and basic (pH approximately 8) p...