Proteomic consequences of expression and pathological conversion of the prion protein in inducible neuroblastoma N2a cells [0.03%]
可诱导神经母细胞瘤N2a细胞中朊病毒蛋白表达和病理学转换的蛋白质组学影响
Monique Provansal,Stéphane Roche,Manuela Pastore et al.
Monique Provansal et al.
Neurodegenerative diseases are often associated with misfolding and deposition of specific proteins in the nervous system. The prion protein, which is associated with transmissible spongiform encephalopathies (TSEs), is one of them. The nor...
Structural requirements for efficient prion protein conversion: cofactors may promote a conversion-competent structure for PrP(C) [0.03%]
有效朊病毒蛋白转化的结构需求：辅助因子可能促进PrPC向易于转化的构象变化
Andrew C Gill,Sonya Agarwal,Teresa J T Pinheiro et al.
Andrew C Gill et al.
To understand why cross-species infection of prion disease often results in inefficient transmission and reduced protein conversion, most research has focused on defining the effect of variations in PrP primary structures, including sequenc...
Alexey V Krasnoslobodtsev,Alexander M Portillo,Tanja Deckert-Gaudig et al.
Alexey V Krasnoslobodtsev et al.
Misfolding and aggregation of prion proteins is linked to a number of neurodegenerative disorders such as Creutzfeldt-Jacob disease (CJD) and its variants: Kuru, Gerstmann-Straussler-Scheinker syndrome and fatal familial insomnia. In prion ...
Robert Hnasko,Ana V Serban,George Carlson et al.
Robert Hnasko et al.
Prion diseases are fatal neurodegenerative disorders caused by prion proteins (PrP). Infectious prions accumulate in the brain through a template-mediated conformational conversion of endogenous PrP(C) into alternately folded PrP(Sc). Immun...
Cell-based immunotherapy of prion diseases by adoptive transfer of antigen-loaded dendritic cells or antigen-primed CD(4+) T lymphocytes [0.03%]
采用抗原负载型树突细胞或抗原活化型CD4+T淋巴细胞过继转移的基于细胞的朊病毒病免疫治疗
Claude Carnaud,Véronique Bachy
Claude Carnaud
Prion diseases are neurodegenerative conditions caused by the transconformation of a normal host glycoprotein, the cellular prion protein (PrPc) into a neurotoxic, self-aggregating conformer (PrPSc). TSEs are ineluctably fatal and no treatm...
The effects of amino acid composition on yeast prion formation and prion domain interactions [0.03%]
氨基酸组成对酵母菌丝素形成及菌丝素结构域相互作用的影响
Eric D Ross,James A Toombs
Eric D Ross
Yeast prions provide a powerful model system for examining prion formation and propagation in vivo. Yeast prion formation is driven primarily by amino acid composition, not by primary amino acid sequence. However, although yeast prion domai...
Rodrigo Diaz-Espinoza,Claudio Soto
Rodrigo Diaz-Espinoza
Prions are self-propagating proteinaceous infectious agents capable of transmitting disease in the absence of nucleic acids. The nature of the infectious agent in prion diseases has been at the center of passionate debate for the past 30 ye...
Transcription of Alu DNA elements in blood cells of sporadic Creutzfeldt-Jakob disease (sCJD) [0.03%]
散发性克雅氏病(sCJD)患者血液细胞中AluDNA元件转录水平的研究
Petra Kiesel,Toby J Gibson,Barbara Ciesielczyk et al.
Petra Kiesel et al.
Alu DNA elements were long considered to be of no biological significance and thus have been only poorly defined. However, in the past Alu DNA elements with well-defined nucleotide sequences have been suspected to contribute to disease, but...
Anja Böckmann,Beat H Meier
Anja Böckmann
The prion hypothesis states that the prion and non-prion form of a protein differ only in their 3D conformation and that different strains of a prion differ by their 3D structure. Recent technical developments have enabled solid-state NMR t...
Reduction of PrP(C) in human cerebrospinal fluid after spinal cord injury [0.03%]
脊髓损伤后人类脑脊液中的PrP(C)减少
Anna Carnini,Steve Casha,V Wee Yong et al.
Anna Carnini et al.
It has been estimated that cerebrospinal fluid (CSF) contains approximately 80 proteins that significantly increase or decrease in response to various clinical conditions. Here we have evaluated the CSF protein PrP(C) (cellular prion protei...
Randomized Controlled Trial
Prion. 2010 Apr-Jun;4(2):80-6. DOI:10.4161/pri.4.2.11756 2010