Bianca Da Costa Dias,Katarina Jovanovic,Stefan F T Weiss
Bianca Da Costa Dias
Neurodegenerative diseases are caused by proteinaceous aggregates, usually consisting of misfolded proteins which are often typified by a high proportion of β-sheets, which accumulate in the Central Nervous System. These diseases, includin...
Maria Udan,Robert H Baloh
Maria Udan
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are clinically overlapping neurodegenerative disorders whose pathophysiology remains incompletely understood. ALS initiates in a discrete location, and typical...
Combination of the somatic cell nuclear transfer method and RNAi technology for the production of a prion gene-knockdown calf using plasmid vectors harboring the U6 or tRNA promoter [0.03%]
利用U6或tRNA启动子质粒载体结合体细胞核移植和RNA干扰技术生产PrP基因敲低牛
Pimprapar Wongsrikeao,Shizuyo Sutou,Miho Kunishi et al.
Pimprapar Wongsrikeao et al.
By combining RNAi technology with SCNT method, we attempted to produce transgenic calves with knocked down bPRNP for technological assessments. The respective utilities of type II (tRNA) and type III (hU6) Pol III promoters in mediating pla...
Prion protein in Caenorhabditis elegans: Distinct models of anti-BAX and neuropathology [0.03%]
秀丽杆线虫的朊病毒蛋白：抗BAX和神经病理模型的不同类型
Kyung-Won Park,Liming Li
Kyung-Won Park
The infectious agent of prion diseases is believed to be nucleic acid-free particles composed of misfolded conformational isomers of a host protein known as prion protein (PrP). Although this "protein-only" concept is generally accepted, de...
The toxicity of an "artificial" amyloid is related to how it interacts with membranes [0.03%]
人工淀粉样蛋白的毒性与其与膜的相互作用有关
Julien Couthouis,Christelle Marchal,Fabien D&#x;Angelo et al.
Julien Couthouis et al.
Despite intensive research into how amyloid structures can impair cellular viability, the molecular nature of these toxic species and the cellular mechanisms involved are not clearly defined and may differ from one disease to another. We sy...
Striatal pathology underlies prion infection-mediated hyperactivity in mice [0.03%]
小鼠海绵状脑病感染介导的过度活动与纹状体病变有关
Keith M Gunapala,Daniel Chang,Cynthia T Hsu et al.
Keith M Gunapala et al.
Although prion diseases are most commonly modeled using the laboratory mouse, the diversity of prion strains, behavioral testing and neuropathological assessments hamper our collective understanding of mouse models of prion disease. Here we...
Glenn C Telling
Glenn C Telling
While prions share the ability to propagate strain information with nucleic acid-based pathogens, it is unclear how they mutate and acquire fitness in the absence of this informational component. Because prion diseases occur as epidemics, u...
Kevin C Gough,Ben C Maddison
Kevin C Gough
Prion diseases range from being highly infectious, for example scrapie and CWD, which show facile transmission between susceptible individuals, to showing negligible horizontal transmission, such as BSE and CJD, which are spread via food or...
Daniel Otzen
Daniel Otzen
Evidence is growing at an increasing -pace that amyloid fibers are not just the result of aberrant protein folding associated with neurodegenerative diseases, but are widespread in nature for beneficial reasons. Amyloid is an attractive bui...
Countering amyloid polymorphism and drug resistance with minimal drug cocktails [0.03%]
用最少的药物配对来对抗淀粉样蛋白多态性和药物耐受性
Martin L Duennwald,James Shorter
Martin L Duennwald
Several fatal, progressive neurodegenerative diseases, including various prion and prion-like disorders, are connected with the misfolding of specific proteins. These proteins misfold into toxic oligomeric species and a spectrum of distinct...