Aggregated proteins in schizophrenia and other chronic mental diseases: DISC1opathies [0.03%]
精神分裂症和其他慢性精神疾病中的聚集蛋白：DISC1opathy
Carsten Korth
Carsten Korth
Chronic mental diseases (CMD) like the schizophrenias are progressive diseases of heterogenous but poorly understood biological origin. An imbalance in proteostasis is a hallmark of dysfunctional neurons, leading to impaired clearance and a...
Disease phenotype in sheep after infection with cloned murine scrapie strains [0.03%]
小鼠搔痒病株克隆感染绵羊后的发病表型
Silvia Sisó,Francesca Chianini,Sam L Eaton et al.
Silvia Sisó et al.
Prion diseases exhibit different disease phenotypes in their natural hosts and when transmitted to rodents, and this variability is regarded as indicative of prion strain diversity. Phenotypic characterization of scrapie strains in sheep ca...
Christina D Orrù,Jason M Wilham,Sarah Vascellari et al.
Christina D Orrù et al.
The ability of abnormal TSE-associated forms of PrP to seed the formation of amyloid fibrils from recombinant PrP(Sen) has served as the basis for several relatively rapid and highly sensitive tests for prion diseases. These tests include r...
Influence of prion variant and yeast strain variation on prion-molecular chaperone requirements [0.03%]
朊毒体变异及酵母菌株差异对朊毒体-分子伴侣需求的影响
Justin K Hines,Takashi Higurashi,Mathangi Srinivasan et al.
Justin K Hines et al.
Prions of budding yeast serve as a tractable model of amyloid behavior. Here we address the issue of the effect of yeast strain variation on prion stability, focusing also on the effect of amyloid conformation and the involvement of the co-...
Zhiqiang Du
Zhiqiang Du
Prions are infectious proteins with altered conformations converted from otherwise normal host proteins. While there is only one known mammalian prion protein, PrP, a handful of prion proteins have been identified in the yeast Saccharomyces...
Hiroshi Kurahashi,Keita Oishi,Yoshikazu Nakamura
Hiroshi Kurahashi
Prions are infectious, self-propagating protein conformations. [PSI+], [RNQ+] and [URE3] are well characterized prions in Saccharomyces cerevisiae and represent the aggregated states of the translation termination factor Sup35, a functional...
SUP35 expression is enhanced in yeast containing [ISP+], a prion form of the transcriptional regulator Sfp1 [0.03%]
含有[ISP+]的酵母中SUP35表达增强，[ISP+]是转录调节因子Sfp1的一种朊毒体形式
Elina Radchenko,Tatyana Rogoza,Maria Khokhrina et al.
Elina Radchenko et al.
[ISP+] is a prion form of the global transcriptional regulator Sfp1 in Saccharomyces cerevisiae that manifests phenotypically as an antisuppressor of specific sup35 nonsense suppressor mutations. Although SUP35 is a Sfp1 target, the mechani...
E. coli chaperones DnaK, Hsp33 and Spy inhibit bacterial functional amyloid assembly [0.03%]
大肠杆菌分子伴侣DnaK，Hsp33和Spy抑制细菌功能淀粉样蛋白的聚集
Margery L Evans,Jens C Schmidt,Marianne Ilbert et al.
Margery L Evans et al.
Amyloid formation is an ordered aggregation process, where β-sheet rich polymers are assembled from unstructured or partially folded monomers. We examined how two Escherichia coli cytosolic chaperones, DnaK and Hsp33, and a more recently c...
Modeling ALS and FTLD proteinopathies in yeast: an efficient approach for studying protein aggregation and toxicity [0.03%]
酵母中ALS和FTLD蛋白异常沉积的建模：一种研究蛋白质聚集和毒性的有效方法
Dmitry Kryndushkin,Frank Shewmaker
Dmitry Kryndushkin
In recent years there have been several reports of human neurodegenerative diseases that involve protein misfolding being modeled in the yeast Saccharomyces cerevisiae. This review summarizes recent advances in understanding the specific me...
The yeast prions [PSI+] and [URE3] are molecular degenerative diseases [0.03%]
酵母的[PSI+]和[Ure3]分子病态疾病性质理论
Reed B Wickner,Herman K Edskes,David Bateman et al.
Reed B Wickner et al.
The yeast prions [URE3] and [PSI] are not found in wild strains, suggesting they are not an advantage. Prion-forming ability is not conserved, even within Saccharomyces, suggesting it is a disease. Prion domains have non-prion functions, ex...