Polymorphisms and variants in the prion protein sequence of European moose (Alces alces), reindeer (Rangifer tarandus), roe deer (Capreolus capreolus) and fallow deer (Dama dama) in Scandinavia [0.03%]
北欧黇鹿、黇鹿、驯鹿和梅花鹿朊病毒蛋白序列的多态性和变异体
Lotta Wik,Sofia Mikko,Mikael Klingeborn et al.
Lotta Wik et al.
The prion protein (PrP) sequence of European moose, reindeer, roe deer and fallow deer in Scandinavia has high homology to the PrP sequence of North American cervids. Variants in the European moose PrP sequence were found at amino acid posi...
Patrick C A van der Wel
Patrick C A van der Wel
For several different proteins an apparent correlation has been observed between the propensity for dimerization by domain-swapping and the ability to aggregate into amyloid-like fibrils. Examples include the disease-related proteins β 2-m...
Phenotypic characterization of cells participating in transport of prion protein aggregates across the intestinal mucosa of sheep [0.03%]
绵羊肠黏膜处参与朊病毒蛋白聚集物转运的细胞表型特征分析
Caroline Piercey Åkesson,Charles McL Press,Michael A Tranulis et al.
Caroline Piercey Åkesson et al.
The oral route is considered to be the main entry site of several transmissible spongiform encephalopathies or prion diseases of animals and man. Following natural and experimental oral exposure to scrapie, sheep first accumulate disease as...
Unraveling the neuroprotective mechanisms of PrP (C) in excitotoxicity [0.03%]
解缠PrP(C)在兴奋毒性中的神经保护机制
Franc Llorens,José Antonio Del Río
Franc Llorens
Knowledge of the natural roles of cellular prion protein (PrP (C) ) is essential to an understanding of the molecular basis of prion pathologies. This GPI-anchored protein has been described in synaptic contacts, and loss of its synaptic fu...
The end of the road [0.03%]
走投无路
Charles Weissmann
Charles Weissmann
After some 60 years in research, a few months before my final retirement (there were a few temporary ones), the time has come to reminisce.
Marilene H Lopes,Tiago G Santos
Marilene H Lopes
Prion protein (PrP) can be considered a pivotal molecule because it interacts with several partners to perform a diverse range of critical biological functions that might differ in embryonic and adult cells. In recent years, there have been...
Using small molecule reagents to selectively modify epitopes based on their conformation [0.03%]
利用小分子试剂基于构象选择性修饰表位
Christopher J Silva
Christopher J Silva
PrP(Sc) is an infectious protein. The only experimentally verified difference between PrP(Sc) and its normal cellular isoform (PrP(C)) is conformational. This work describes an approach to determining the presence of surface exposed or sequ...
Nanopore analysis: An emerging technique for studying the folding and misfolding of proteins [0.03%]
纳米孔分析：一种研究蛋白质折叠和错误折叠的新兴技术
Claudia Madampage,Omid Tavassoly,Chris Christensen et al.
Claudia Madampage et al.
Nanopore analysis is an emerging technique that enables the investigation of the conformation of a single peptide or protein molecule. Briefly, a pore is inserted into a membrane under voltage clamp conditions. When a molecule interacts wit...
Jiri G Safar
Jiri G Safar
The yeast, fungal and mammalian prions determine heritable and infectious traits that are encoded in alternative conformations of proteins. They cause lethal sporadic, familial and infectious neurodegenerative conditions in man, including C...
The diverse roles of mononuclear phagocytes in prion disease pathogenesis [0.03%]
单核吞噬细胞在朊病毒病发病机制中的多种作用
Gwennaelle J Wathne,Neil A Mabbott
Gwennaelle J Wathne
Transmissible spongiform encephalopathies (TSEs), or prion diseases, are neurological diseases that can be transmitted through a number of different routes. A wide range of mammalian species are affected by the disease. After peripheral exp...