Chronic wasting disease: fingerprinting the culprit in risk assessments [0.03%]
慢性消耗性疾病：风险评估中的元凶指纹识别
Martin L Daus,Michael Beekes
Martin L Daus
Transmissible spongiform encephalopathies (prion diseases) in animals may be associated with a zoonotic risk potential for humans as shown by the occurrence of variant Creutzfeldt-Jakob disease in the wake of the bovine spongiform encephalo...
Cynthia M Rodriguez,James P Bennett,Christopher J Johnson
Cynthia M Rodriguez
The prion diseases sheep scrapie and cervid chronic wasting disease are transmitted, in part, via an environmental reservoir of infectivity; prions released from infected animals persist in the environment and can cause disease years later....
Cynthia M Rodriguez,James P Bennett,Christopher J Johnson
Cynthia M Rodriguez
The prion diseases sheep scrapie and cervid chronic wasting disease are transmitted, in part, via an environmental reservoir of infectivity; prions released from infected animals persist in the environment and can cause disease years later....
Global Alzheimer Research Summit: basic and clinical research: present and future Alzheimer research [0.03%]
全球阿尔茨海默病研究峰会：现况与未来——基础及临床研究
Danielle Gonsalves,Katarina Jovanovic,Bianca Da Costa Dias et al.
Danielle Gonsalves et al.
We report here on the proceedings of the Global Alzheimer Summit that took place September 22-23, 2011 in Madrid, Spain. As Alzheimer disease (AD) is the leading cause of neurodegeneration in elderly individuals and as yet has no effective ...
Global Alzheimer Research Summit: basic and clinical research: present and future Alzheimer research [0.03%]
全球阿尔茨海默病研究峰会：现况与未来——从基础到临床研究
Danielle Gonsalves,Katarina Jovanovic,Bianca Da Costa Dias et al.
Danielle Gonsalves et al.
We report here on the proceedings of the Global Alzheimer Summit that took place September 22-23, 2011 in Madrid, Spain. As Alzheimer disease (AD) is the leading cause of neurodegeneration in elderly individuals and as yet has no effective ...
Harnessing prions as test agents for the development of broad-range disinfectants [0.03%]
利用朊病毒作为开发广谱消毒剂的检测剂
Katja Wagenführ,Michael Beekes
Katja Wagenführ
The development of disinfectants with broad-range efficacy against bacteria, viruses, fungi, protozoa and prions constitutes an ongoing challenge. Prions, the causative agents of transmissible spongiform encephalopathies (TSEs) such as Creu...
Harnessing prions as test agents for the development of broad-range disinfectants [0.03%]
利用朊病毒作为开发广谱消毒剂的检测菌种
Katja Wagenführ,Michael Beekes
Katja Wagenführ
The development of disinfectants with broad-range efficacy against bacteria, viruses, fungi, protozoa and prions constitutes an ongoing challenge. Prions, the causative agents of transmissible spongiform encephalopathies (TSEs) such as Creu...
Heledd H Griffiths,Isobel J Whitehouse,Nigel M Hooper
Heledd H Griffiths
Alzheimer disease (AD) is characterized by the amyloidogenic processing of the amyloid precursor protein (APP), culminating in the accumulation of amyloid-β peptides in the brain. The enzymatic action of the β-secretase, BACE1 is the rate...
Probing the role of structural features of mouse PrP in yeast by expression as Sup35-PrP fusions [0.03%]
通过在酵母中作为Sup35-PrP融合蛋白表达来探讨小鼠PrP结构特征的作用
Lyne Jossé,Ricardo Marchante,Jo Zenthon et al.
Lyne Jossé et al.
The yeast Saccharomyces cerevisiae is a tractable model organism in which both to explore the molecular mechanisms underlying the generation of disease-associated protein misfolding and to map the cellular responses to potentially toxic mis...
Patterns of [PSI (+) ] aggregation allow insights into cellular organization of yeast prion aggregates [0.03%]
［PSI＋］聚集模式有助于了解酵母朊病毒聚集体的细胞组织方式
Jens Tyedmers
Jens Tyedmers
The yeast prion phenomenon is very widespread and mounting evidence suggests that it has an impact on cellular regulatory mechanisms related to phenotypic responses to changing environments. Studying the aggregation patterns of prion amyloi...