Ion channels induced by the prion protein: mediators of neurotoxicity [0.03%]
诱导于朊病毒蛋白的离子通道：神经毒性的媒介体
Isaac H Solomon,Emiliano Biasini,David A Harris
Isaac H Solomon
Prion diseases comprise a group of rapidly progressive and invariably fatal neurodegenerative disorders for which there are no effective treatments. While conversion of the cellular prion protein (PrP(C)) to a β-sheet rich isoform (PrP(Sc)...
Giuseppe Legname
Giuseppe Legname
The conversion to a disease-associated conformer (PrP(Sc)) of the cellular prion protein (PrP(C)) is the central event in prion diseases. Wild-type PrPC converts to PrP(Sc) in the sporadic forms of the disorders through an unknown mechanism...
Giuseppe Legname
Giuseppe Legname
The conversion to a disease-associated conformer (PrP(Sc)) of the cellular prion protein (PrP(C)) is the central event in prion diseases. Wild-type PrPC converts to PrP(Sc) in the sporadic forms of the disorders through an unknown mechanism...
Ralph Andre,Sarah J Tabrizi
Ralph Andre
Prion diseases comprise a family of fatal neurodegenerative disorders caused by the conformational re-arrangement of a normal host-encoded protein, PrP (C) , to an abnormal infectious isoform termed PrP (Sc) . Currently, the precise cellula...
Ralph Andre,Sarah J Tabrizi
Ralph Andre
Prion diseases comprise a family of fatal neurodegenerative disorders caused by the conformational re-arrangement of a normal host-encoded protein, PrP (C) , to an abnormal infectious isoform termed PrP (Sc) . Currently, the precise cellula...
Insights into the disparate action of osmolytes and macromolecular crowders on amyloid formation [0.03%]
渗透压型小分子和大分子对淀粉样纤维组装的不同调控作用机制研究
Shahar Sukenik,Daniel Harries
Shahar Sukenik
It is widely recognized that amyloid formation sensitively responds to conditions set by myriad cellular solutes. These cosolutes include two important classes: macromolecular crowders and compatible osmolytes. We have recently found that a...
Insights into the disparate action of osmolytes and macromolecular crowders on amyloid formation [0.03%]
渗透压型小分子和大分子对淀粉样纤维组装的不同作用机制及机理探究
Shahar Sukenik,Daniel Harries
Shahar Sukenik
It is widely recognized that amyloid formation sensitively responds to conditions set by myriad cellular solutes. These cosolutes include two important classes: macromolecular crowders and compatible osmolytes. We have recently found that a...
Two-steps control of cellular prion physiology by the extracellular regulated kinase-1 (ERK1) [0.03%]
细胞外调节激酶1(ERK1)对细胞内朊病毒生理的双重调控作用
Frédéric Checler
Frédéric Checler
Cellular prion (PrP(c)) undergoes a regulated α-secretase-like cleavage by the disintegrin ADAM17 similar to the one taking place on β-amyloid precursor protein (βAPP). Because these cleavages give rise to biologically active fragments, ...
Two-steps control of cellular prion physiology by the extracellular regulated kinase-1 (ERK1) [0.03%]
细胞外调节激酶1(ERK1)对细胞型朊病毒生理的双重调控作用
Frédéric Checler
Frédéric Checler
Cellular prion (PrP(c)) undergoes a regulated α-secretase-like cleavage by the disintegrin ADAM17 similar to the one taking place on β-amyloid precursor protein (βAPP). Because these cleavages give rise to biologically active fragments, ...
Chronic wasting disease: fingerprinting the culprit in risk assessments [0.03%]
慢性消耗性疾病：风险评估中的病原体指纹识别技术
Martin L Daus,Michael Beekes
Martin L Daus
Transmissible spongiform encephalopathies (prion diseases) in animals may be associated with a zoonotic risk potential for humans as shown by the occurrence of variant Creutzfeldt-Jakob disease in the wake of the bovine spongiform encephalo...