Y145Stop is sufficient to induce de novo generation prions using protein misfolding cyclic amplification [0.03%]
Y145STOP足够通过蛋白质错误折叠循环放大来诱导新产生的普里昂
Ahmed Abdallah,Ping Wang,Juergen A Richt et al.
Ahmed Abdallah et al.
A point mutation in Prnp that converts tyrosine (Y) at position 145 into a stop codon leading to a truncated prion molecule as found in an inherited transmissible spongiform encephalopathy (TSE), Gertsmann-Sträussler-Scheincker syndrome, s...
Y145Stop is sufficient to induce de novo generation prions using protein misfolding cyclic amplification [0.03%]
Y145STOP足够通过蛋白误折叠循环放大诱导de novo产生朊病毒
Ahmed Abdallah,Ping Wang,Juergen A Richt et al.
Ahmed Abdallah et al.
A point mutation in Prnp that converts tyrosine (Y) at position 145 into a stop codon leading to a truncated prion molecule as found in an inherited transmissible spongiform encephalopathy (TSE), Gertsmann-Sträussler-Scheincker syndrome, s...
PRND 3'UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease [0.03%]
PRND 3'UTR多态性可能与阿尔茨海默病的行为障碍有关
Marcin Flirski,Monika Sieruta,Ewa Golańska et al.
Marcin Flirski et al.
The etiology of behavioral and psychological symptoms of dementia (BPSD) is complex, including putative biological, psychological, social and environmental factors. Recent years have witnessed accumulation of data on the association between...
PRND 3'UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease [0.03%]
PRND 3'UTR多态性可能与阿尔茨海默病的行为障碍有关
Marcin Flirski,Monika Sieruta,Ewa Golańska et al.
Marcin Flirski et al.
The etiology of behavioral and psychological symptoms of dementia (BPSD) is complex, including putative biological, psychological, social and environmental factors. Recent years have witnessed accumulation of data on the association between...
Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie [0.03%]
新型γ分泌酶调节剂CHF5074的治疗作用及其在 Scrapie 小鼠模型中的作用研究
Giorgio Poli,Erica Corda,Barbara Lucchini et al.
Giorgio Poli et al.
In Transmissible Spongiform Encephalopathies (TSEs) and Alzheimer disease (AD) both misfolding and aggregation of specific proteins represent key features. Recently, it was observed that PrP (c) is a mediator of a synaptic dysfunction induc...
Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie [0.03%]
新型γ-分泌酶调节剂CHF5074的治疗效果及其在羊瘙痒病小鼠模型中的作用机制
Giorgio Poli,Erica Corda,Barbara Lucchini et al.
Giorgio Poli et al.
In Transmissible Spongiform Encephalopathies (TSEs) and Alzheimer disease (AD) both misfolding and aggregation of specific proteins represent key features. Recently, it was observed that PrP (c) is a mediator of a synaptic dysfunction induc...
Gültekin Tamgüney,Jürgen A Richt,Amir N Hamir et al.
Gültekin Tamgüney et al.
Scrapie of sheep and chronic wasting disease (CWD) of cervids are transmissible prion diseases. Milk and placenta have been identified as sources of scrapie prions but do not explain horizontal transmission. In contrast, CWD prions have bee...
Comparative peptidome analyses of the profiles of the peptides ranging from 1-10 KD in CSF samples pooled from probable sporadic CJD and non-CJD patients [0.03%]
比较性肽组分析从可能的散发性CJD和非CJD患者脑脊液样品中获得的1-10KD肽段图谱
Cao Chen,Di Xiao,Wei Zhou et al.
Cao Chen et al.
The shotgun strategy applying tandem mass spectrometry has been widely used to identify the proteins that are differentially distributed among diseases for its high reliability and efficiency. To find out the potential difference of protein...
Comparative Study
Prion. 2012 Jan-Mar;6(1):46-51. DOI:10.4161/pri.6.1.18082 2012
Comparative peptidome analyses of the profiles of the peptides ranging from 1-10 KD in CSF samples pooled from probable sporadic CJD and non-CJD patients [0.03%]
比较性肽组分析1-10KD脑脊液肽段 probable sporadic CJD和非CJD患者样本中的差异
Cao Chen,Di Xiao,Wei Zhou et al.
Cao Chen et al.
The shotgun strategy applying tandem mass spectrometry has been widely used to identify the proteins that are differentially distributed among diseases for its high reliability and efficiency. To find out the potential difference of protein...
Comparative Study
Prion. 2012 Jan-Mar;6(1):46-51. DOI:10.4161/pri.6.1.18082 2012
Isaac H Solomon,Emiliano Biasini,David A Harris
Isaac H Solomon
Prion diseases comprise a group of rapidly progressive and invariably fatal neurodegenerative disorders for which there are no effective treatments. While conversion of the cellular prion protein (PrP(C)) to a β-sheet rich isoform (PrP(Sc)...