Association between transforming growth factor-beta(1) and left ventricular mass and diameter in hypertensive patients [0.03%]
转化生长因子-β1与高血压患者左心室质量及直径的关系
Jesus L Almendral,Vladislav Shick,Clive Rosendorff et al.
Jesus L Almendral et al.
Angiotensin II influences development of left ventricular hypertrophy (LVH) by stimulating cardiomyocyte hypertrophy, fibroblast proliferation, and collagen synthesis. Because pro-fibrotic actions of angiotensin may be mediated by increased...
Influence of calcium-dependent potassium channel blockade and nitric oxide inhibition on norepinephrine-induced contractions in two forms of genetic hypertension [0.03%]
钙依赖性钾通道阻断和一氧化氮抑制对两种遗传性高血压模型中去甲肾上腺素收缩作用的影响
Silvia Lísková,Miriam Petrová,Petr Karen et al.
Silvia Lísková et al.
The activation of Ca(2+)-dependent K(+) channels (BK(Ca)) leads to the attenuation of vascular contraction. Our study aimed to evaluate BK(Ca) influence on norepinephrine (NE)-induced femoral artery contraction in two forms of genetic hyper...
Methods and potential biomarkers for the evaluation of endothelial dysfunction in chronic kidney disease: a critical approach [0.03%]
慢性肾脏病内皮功能障碍的评估方法和潜在生物标志物：一种批判性方法
Simona M Hogas,Luminita Voroneanu,Dragomir N Serban et al.
Simona M Hogas et al.
The impressive cardiovascular morbidity and mortality of chronic kidney disease (CKD) patients is attributable in a significant proportion to endothelial dysfunction (ED), arterial stiffness, and vascular calcifications. Abnormal vascular r...
A review of endothelial dysfunction in diabetes: a focus on the contribution of a dysfunctional eNOS [0.03%]
糖尿病内皮功能障碍的评述：以内皮型一氧化氮合酶(eNOS)功能失调为重点的研究进展
Chris R Triggle,Hong Ding
Chris R Triggle
Although the etiology of vascular dysfunction in diabetes has been extensively investigated in both humans as well as animal models of human diabetes, the relative importance of the cellular pathways involved is still not fully understood. ...
From the editor [0.03%]
编者来信
Myron H Weinberger
Myron H Weinberger
Mieczyslaw Litwin,Anna Niemirska,Marcel Ruzicka et al.
Mieczyslaw Litwin et al.
The clinical significance of white coat hypertension (WCH) remains uncertain. We aimed to evaluate the target organ damage (TOD) in children with essential hypertension (HTN) and WCH. We retrospectively analyzed the body mass index (BMI) an...
Costs associated with cardiovascular events in patients with hypertension in US managed care settings [0.03%]
美国医疗保健环境中高血压患者心血管事件的相关费用
Mei Sheng Duh,Nicole M Fulcher,Leigh Ann White et al.
Mei Sheng Duh et al.
Study quantified incremental cost of cardiovascular (CV) events in 6 high-risk and compelling indication subgroups: post-myocardial infarction (MI), diabetes, diabetic nephropathy, elderly, chronic kidney disease, and prior stroke. Based on...
An evaluation of the efficacy of olmesartan medoxomil in Black patients with hypertension [0.03%]
评估奥美沙坦酯治疗高血压黑人患者疗效的Meta分析
Thomas D Giles,Suzanne Oparil,Antonia Wang et al.
Thomas D Giles et al.
Blacks appear to have a more modest blood pressure (BP) response to angiotensin receptor blocker (ARB) monotherapy than non-Blacks. This post-hoc analysis compared the BP-lowering efficacy of olmesartan medoxomil (OM), losartan potassium (L...
Diagnostic accuracy of flow-mediated dilatation and intima-media thickness for the presence of significant coronary artery disease [0.03%]
血流介导的血管扩张和内膜中层厚度诊断冠状动脉疾病的价值
Iana Simova,Tsvetana Katova,Stefan Denchev
Iana Simova
Our purpose was to determine and compare the diagnostic accuracy of flow-mediated dilatation (FMD) and intima-media thickness (IMT). Included were 543 patients. FMD was performed in 543 patients, IMT in 233, and coronary arteriography (CAG)...
O-GlcNAcylation: a novel post-translational mechanism to alter vascular cellular signaling in health and disease: focus on hypertension [0.03%]
O-GlcNAc酰化：一种通过影响细胞信号转导参与健康和高血压病理生理的新的翻译后修饰机制
Victor V Lima,Christiné S Rigsby,David M Hardy et al.
Victor V Lima et al.
O-Linked attachment of beta-N-acetyl-glucosamine (O-GlcNAc) on serine and threonine residues of nuclear and cytoplasmic proteins is a highly dynamic posttranslational modification that plays a key role in signal transduction pathways. Preli...