Moderate versus intensive treatment of hypertension using amlodipine/valsartan and with the addition of hydrochlorothiazide for patients uncontrolled on angiotensin receptor blocker monotherapy: results in racial/ethnic subgroups [0.03%]
中度与重度高血压治疗：氨氯地平/缬沙坦联合氢氯噻嗪对单用血管紧张素受体阻滞剂疗效不佳患者的亚种族/族裔群体研究结果
Elizabeth O Ofili,Suzanne Oparil,Thomas Giles et al.
Elizabeth O Ofili et al.
Combination therapy may reduce racial/ethnic differences in response to antihypertensives. In this post-hoc analysis, we evaluated treatment response by race/ethnicity among hypertensive adults enrolled in a 12-week, double-blind study in w...
Randomized Controlled Trial
Journal of the American Society of Hypertension : JASH. 2011 Jul-Aug;5(4):249-58. DOI:10.1016/j.jash.2011.02.007 2011
Indexing cardiac parameters in echocardiographic practice: do estimates depend on how weight and height have been assessed? A study on left atrial dilatation [0.03%]
超声心动图实践中心脏参数的指数化：体重和身高评估方式的不同，左心房扩张的估计值是否有所不同？
Cesare Cuspidi,Francesca Negri,Maria Lorenza Muiesan et al.
Cesare Cuspidi et al.
We examined the difference between self-reported and measured height and weight in detecting echocardiographic left atrial dilatation (LAD), as defined by LA diameter indexed to body size parameters in an outpatient population referred to e...
Mitochondrial aldehyde dehydrogenase prevents ROS-induced vascular contraction in angiotensin-II hypertensive mice [0.03%]
线粒体乙醛脱氢酶可预防血管紧张素Ⅱ型高血压小鼠的活性氧介导的血管收缩现象
Hyehun Choi,Rita C Tostes,R Clinton Webb
Hyehun Choi
Mitochondrial aldehyde dehydrogenase (ALDH2) is an enzyme that detoxifies aldehydes to carboxylic acids. ALDH2 deficiency is known to increase oxidative stress, which is the imbalance between reactive oxygen species (ROS) generation and ant...
Hypertension in peritoneal dialysis patients: epidemiology, pathogenesis, and treatment [0.03%]
腹膜透析患者的高血压：流行病学、发病机制及治疗措施
Luis M Ortega,Barry J Materson
Luis M Ortega
Hypertension is prevalent in an estimated 29% to 80% of patients treated with peritoneal dialysis (PD). Cardiovascular disease represents the most common cause of mortality in this population, and hypertension (HTN) plays an important role....
Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR [0.03%]
在WKY和SHR血管平滑肌细胞中Nox1、Nox2和Nox4的差异调节
Ana M Briones,Fatiha Tabet,Glaucia E Callera et al.
Ana M Briones et al.
The functional significance and regulation of NAD(P)H oxidase (Nox) isoforms by angiotensin II (Ang II) and endothelin-1 (ET-1) in vascular smooth muscle cells (VSMCs) from normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats...
Efficacy and safety of the selective 11β-HSD-1 inhibitors MK-0736 and MK-0916 in overweight and obese patients with hypertension [0.03%]
选择性11β-HSD-1抑制剂MK-0736和MK-0916治疗超重或肥胖合并高血压患者的有效性和安全性
Sukrut Shah,Anne Hermanowski-Vosatka,Kendra Gibson et al.
Sukrut Shah et al.
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) may be involved in several abnormalities associated with the metabolic syndrome. This study evaluated the antihypertensive efficacy and safety of two 11β-HSD1 inhibitors, MK-0736 and MK-...
Randomized Controlled Trial
Journal of the American Society of Hypertension : JASH. 2011 May-Jun;5(3):166-76. DOI:10.1016/j.jash.2011.01.009 2011
Friedrich C Luft
Friedrich C Luft
β2 adrenergic receptor polymorphisms and nocturnal blood pressure dipping status in the Wisconsin Sleep Cohort Study [0.03%]
威斯康星州睡眠队列研究中β2肾上腺素能受体多态性与夜间血压昼夜节律现象的关系
Orly Vardeny,Paul E Peppard,Laurel A Finn et al.
Orly Vardeny et al.
Nondipping nocturnal blood pressure (BP) is associated with target organ damage and cardiovascular disease. We hypothesized that β1- and β2-AR-associated single nucleotide polymorphisms (SNPs) would associate with nondipping BP patterns. ...
Efficacy and safety of aliskiren-based dual and triple combination therapies in US minority patients with stage 2 hypertension [0.03%]
评估阿利吉仑为基础的双联及三联疗法治疗美国少数族裔2级高血压患者的有效性和安全性的研究
Keith C Ferdinand,Richard Weitzman,Marc Israel et al.
Keith C Ferdinand et al.
Minority patients with hypertension generally require combination therapy to reach blood pressure (BP) goals. We examined the BP-lowering efficacy and safety of combination aliskiren/amlodipine therapy in self-identified minority patients i...
Randomized Controlled Trial
Journal of the American Society of Hypertension : JASH. 2011 Mar-Apr;5(2):102-13. DOI:10.1016/j.jash.2011.01.006 2011
Effect of beta blockers on central aortic pressure in African-Americans [0.03%]
β受体阻滞剂对非裔美国人中心主动脉压的影响
Haroon Kamran,Louis Salciccioli,Carl Bastien et al.
Haroon Kamran et al.
The objective of this study was to evaluate the vascular effects of heart rate (HR) reduction with BB therapy in African Americans (AA). Beta-blockers (BB) offer less cardiovascular protection than other hypertensive drugs. Studies of Cauca...