Daniela M Witten,Robert Tibshirani
Daniela M Witten
We consider the problem of testing the significance of features in high-dimensional settings. In particular, we test for differentially-expressed genes in a microarray experiment. We wish to identify genes that are associated with some type...
Hidden Markov models for the assessment of chromosomal alterations using high-throughput SNP arrays [0.03%]
基于高通量SNP阵列的染色体改变的隐马尔可夫模型评估方法研究
Robert B Scharpf,Giovanni Parmigiani,Jonathan Pevsner et al.
Robert B Scharpf et al.
Chromosomal DNA is characterized by variation between individuals at the level of entire chromosomes (e.g. aneuploidy in which the chromosome copy number is altered), segmental changes (including insertions, deletions, inversions, and trans...
A Resampling-Based Test to Detect Person-To-Person Transmission of Infectious Disease [0.03%]
一种基于重采样的检测传染病人际传播的检验方法
Yang Yang,Ira M Longini,M Elizabeth Halloran
Yang Yang
Early detection of person-to-person transmission of emerging infectious diseases such as avian influenza is crucial for containing pandemics. We developed a simple permutation test and its refined version for this purpose. A simulation stud...
STATE-SPACE BASED MASS EVENT-HISTORY MODEL I: MANY DECISION-MAKING AGENTS WITH ONE TARGET [0.03%]
基于状态空间的质量事件历史模型I：多个决策代理和一个目标
Hsieh Fushing,Li Zhu,David I Shapiro-Ilan et al.
Hsieh Fushing et al.
A dynamic decision-making system that includes a mass of indistinguishable agents could manifest impressive heterogeneity. This kind of non-homogeneity is postulated to result from macroscopic behavioral tactics employed by almost all invol...
A Bayesian Framework for Estimating Vaccine Efficacy per Infectious Contact [0.03%]
估计每次感染接触疫苗效力的贝叶斯框架
Yang Yang,Peter Gilbert,Ira M Longini et al.
Yang Yang et al.
In vaccine studies for infectious diseases such as human immunodeficiency virus (HIV), the frequency and type of contacts between study participants and infectious sources are among the most informative risk factors, but are often not adequ...
ASSESSING SURROGATE ENDPOINTS IN VACCINE TRIALS WITH CASE-COHORT SAMPLING AND THE COX MODEL [0.03%]
Cox模型在疫苗试验案例队列抽样中的中介效应分析方法评估终点指标研究
Li Qin,Peter B Gilbert,Dean Follmann et al.
Li Qin et al.
Assessing immune responses to study vaccines as surrogates of protection plays a central role in vaccine clinical trials. Motivated by three ongoing or pending HIV vaccine efficacy trials, we consider such surrogate endpoint assessment in a...
THE RARITY OF DNA PROFILES [0.03%]
DNA图谱的稀有性
Bruce S Weir
Bruce S Weir
It is now widely accepted that forensic DNA profiles are rare, so it was a surprise to some people that different people represented in offender databases are being found to have the same profile. In the first place this is just an illustra...