Adhesion patterning by a novel air-lock technique enables localization and in-situ real-time imaging of reprogramming events in one-to-one electrofused hybrids [0.03%]
一种新型空气锁技术使单个细胞电融合体中的重编程事件定位及原位成像成为可能
S Sakamoto,K O Okeyo,S Yamazaki et al.
S Sakamoto et al.
Although fusion of somatic cells with embryonic stem (ES) cells has been shown to induce reprogramming, single-cell level details of the transitory phenotypic changes that occur during fusion-based reprogramming are still lacking. Our group...
A self-filling microfluidic device for noninvasive and time-resolved single red blood cell experiments [0.03%]
一种自我填充的微流体装置，用于非侵入性和时间分辨的单红细胞实验
Michael Göllner,Adriana C Toma,Natalja Strelnikova et al.
Michael Göllner et al.
Existing approaches to red blood cell (RBC) experiments on the single-cell level usually rely on chemical or physical manipulations that often cause difficulties with preserving the RBC's integrity in a controlled microenvironment. Here, we...
Solar optics-based active panel for solar energy storage and disinfection of greywater [0.03%]
一种基于太阳能光学的主动式集能板用于灰色污水储能和消毒
W Lee,J Song,J H Son et al.
W Lee et al.
Smart city and innovative building strategies are becoming increasingly more necessary because advancing a sustainable building system is regarded as a promising solution to overcome the depleting water and energy. However, current sustaina...
Modulating wall shear stress gradient via equilateral triangular channel for in situ cellular adhesion assay [0.03%]
利用等边三角形通道调节壁面剪切梯度应力进行原位细胞粘附试验
Hyung Woo Kim,Seonjin Han,Wonkyoung Kim et al.
Hyung Woo Kim et al.
This study introduces an equilateral triangular channel (ETRIC), a novel microfluidic channel with an equilateral triangular cross-section, for cell adhesion assay by modulating the wall shear stress (WSS) gradient. The channel can generate...
Spatially dependent diffusion coefficient as a model for pH sensitive microgel particles in microchannels [0.03%]
空间依赖的扩散系数作为微通道中pH敏感性微凝胶颗粒模型
S Pieprzyk,D M Heyes,A C Brańka
S Pieprzyk
Solute transport and intermixing in microfluidic devices is strongly dependent on diffusional processes. Brownian Dynamics simulations of pressure-driven flow of model microgel particles in microchannels have been carried out to explore the...
Modeling the relaxation of internal DNA segments during genome mapping in nanochannels [0.03%]
纳米通道中基因组测绘时内部DNA片段松弛的模拟
Aashish Jain,Julian Sheats,Jeffrey G Reifenberger et al.
Aashish Jain et al.
We have developed a multi-scale model describing the dynamics of internal segments of DNA in nanochannels used for genome mapping. In addition to the channel geometry, the model takes as its inputs the DNA properties in free solution (persi...
A bilayer small diameter in vitro vascular model for evaluation of drug induced vascular injury [0.03%]
一种双层小直径体外血管模型用于评估药物所致血管损伤
David M Hoganson,Eric B Finkelstein,Gwen E Owens et al.
David M Hoganson et al.
In pre-clinical safety studies, drug-induced vascular injury (DIVI) is defined as an adverse response to a drug characterized by degenerative and hyperplastic changes of endothelial cells and vascular smooth muscle cells. Inflammation may a...
Dynamic analysis of immune and cancer cell interactions at single cell level in microfluidic droplets [0.03%]
基于微流控液滴的单细胞水平动态分析免疫与癌细胞相互作用
S Sarkar,P Sabhachandani,D Stroopinsky et al.
S Sarkar et al.
Cell-cell communication mediates immune responses to physiological stimuli at local and systemic levels. Intercellular communication occurs via a direct contact between cells as well as by secretory contact-independent mechanisms. However, ...
Surface micromachining of polydimethylsiloxane for microfluidics applications [0.03%]
用于微流体的聚二甲基硅氧烷表面微细加工技术研究
Staci Hill,Weiyi Qian,Weiqiang Chen et al.
Staci Hill et al.
Polydimethylsiloxane (PDMS) elastomer has emerged as one of the most frequently applied materials in microfluidics. However, precise and large-scale surface micromachining of PDMS remains challenging, limiting applications of PDMS for micro...
3D printed auto-mixing chip enables rapid smartphone diagnosis of anemia [0.03%]
基于智能手机的快速手机贫血诊断的3D打印自动混合芯片
Kimberly Plevniak,Matthew Campbell,Timothy Myers et al.
Kimberly Plevniak et al.
Clinical diagnosis requiring central facilities and site visits can be burdensome for patients in resource-limited or rural areas. Therefore, development of a low-cost test that utilizes smartphone data collection and transmission would ben...