On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood [0.03%]
血液中癌症DNA生物标志物的片上波分复用检测技术
H Cai,M A Stott,D Ozcelik et al.
H Cai et al.
We have developed an optofluidic analysis system that processes biomolecular samples starting from whole blood and then analyzes and identifies multiple targets on a silicon-based molecular detection platform. We demonstrate blood filtratio...
Flexible control of cellular encapsulation, permeability, and release in a droplet-templated bifunctional copolymer scaffold [0.03%]
基于液滴模板的双功能共聚物支架实现细胞封装、渗透性和释放的灵活控制
Qiushui Chen,Dong Chen,Jing Wu et al.
Qiushui Chen et al.
Designing cell-compatible, bio-degradable, and stimuli-responsive hydrogels is very important for biomedical applications in cellular delivery and micro-scale tissue engineering. Here, we report achieving flexible control of cellular microe...
In-flow real-time detection of spectrally encoded microgels for miRNA absolute quantification [0.03%]
基于光谱编码微凝胶的miRNA实时在线绝对定量检测方法研究
David Dannhauser,Filippo Causa,Edmondo Battista et al.
David Dannhauser et al.
We present an in-flow ultrasensitive fluorescence detection of microRNAs (miRNAs) using spectrally encoded microgels. We researched and employed a viscoelastic fluid to achieve an optimal alignment of microgels in a straight measurement cha...
Label-free discrimination of membrane-translocating peptides on porous silicon microfluidic biosensors [0.03%]
无标签膜转移肽的识别技术及微流控生物传感器上的检测方法研究
Zhen Li,Qiaohui Luo,Jianmin Wu
Zhen Li
A label-free optical sensor was constructed by integrating electrochemically etched porous silicon (pSi) and supported phospholipid bilayers in a microfluidic chip. The translocation of peptides through the phospholipid bilayers could induc...
Shape induced acid responsive heat triggered highly facilitated drug release by cube shaped magnetite nanoparticles [0.03%]
形状引发的酸热响应性六面体磁性四氧化三铁纳米载药体系的构建及其药物高效释放机制研究
Debarati De,Madhuri Mandal Goswami
Debarati De
This paper reports a very simple yet better method for synthesis of cube shaped magnetite nanoparticles (MNPs) and their application in the drug delivery system (DDS). Structural analysis was done by XRD measurements to confirm the phase of...
A hybrid microfluidic device for on-demand orientation and multidirectional imaging of C. elegans organs and neurons [0.03%]
一种混合微流体设备，可对C. elegans器官和神经元进行按需定向及多向成像
Ramtin Ardeshiri,Ben Mulcahy,Mei Zhen et al.
Ramtin Ardeshiri et al.
C. elegans is a well-known model organism in biology and neuroscience with a simple cellular (959 cells) and nervous (302 neurons) system and a relatively homologous (40%) genome to humans. Lateral and longitudinal manipulation of C. elegan...
Drop-on-demand inkjet-based cell printing with 30- μ m nozzle diameter for cell-level accuracy [0.03%]
基于按需墨水喷射法的细胞打印技术及其单元精度研究(喷嘴直径为30μm)
Young Kwon Kim,Ju An Park,Woong Hee Yoon et al.
Young Kwon Kim et al.
We present drop-on-demand inkjet-based mammalian cell printing with a 30-μm nozzle diameter for cell-level accuracy. High-speed imaging techniques have been used to analyze the go-and-stop movement of cells inside the nozzle under a pulsed...
Automated electrorotation shows electrokinetic separation of pancreatic cancer cells is robust to acquired chemotherapy resistance, serum starvation, and EMT [0.03%]
自动电旋转显示胰腺癌细胞的电动力学分离具有抗获得性化疗耐药性，血清饥饿和上皮间质转化的能力
Timothy Lannin,Wey-Wey Su,Conor Gruber et al.
Timothy Lannin et al.
We used automated electrorotation to measure the cytoplasmic permittivity, cytoplasmic conductivity, and specific membrane capacitance of pancreatic cancer cells under environmental perturbation to evaluate the effects of serum starvation, ...
Dynamic simulations show repeated narrowing maximizes DNA linearization in elastomeric nanochannels [0.03%]
动态模拟显示反复收缩可最大化弹性纳米通道中的DNA线性化
Minsub Han,Byoung Choul Kim,Toshiki Matsuoka et al.
Minsub Han et al.
This paper uses computer simulations to reveal unprecedented details about linearization of deoxyribonucleic acid (DNA) inside dynamic nanochannels that can be repeatedly widened and narrowed. We first analyze the effect of rate of channel ...
A microfluidic method and custom model for continuous, non-intrusive biofilm viscosity measurements under different nutrient conditions [0.03%]
一种用于连续无损测定生物膜粘度的微流体方法及模型
J Greener,M Parvinzadeh Gashti,A Eslami et al.
J Greener et al.
Straight, low-aspect ratio micro flow cells are used to support biofilm attachment and preferential accumulation at the short side-wall, which progressively reduces the effective channel width. The biofilm shifts downstream at measurable ve...