Beyond the 3 Rs to a More Comprehensive Framework of Principles for Animal Research Ethics [0.03%]
伦理原则的综合框架：超越对动物研究的“3R"讨论
David DeGrazia,Tom L Beauchamp
David DeGrazia
We have produced a framework of general moral principles for animal research ethics in a book, Principles of Animal Research Ethics, which is forthcoming with Oxford University Press in fall 2019. This book includes a detailed statement and...
Gregers Jungersen,Jorge Piedrahita
Gregers Jungersen
Valid interpretation of preclinical animal models in immunology-related clinical challenges is important to solve outstanding clinical needs. Given the overall complexity of the immune system and both species- and tissue-specific immune pec...
Jessica McCormick-Ell,Nancy Connell
Jessica McCormick-Ell
Research with animals presents a wide array of hazards, some of which overlap those in the in vitro research laboratory. The challenge for environmental health and safety professionals when making their recommendations and performing the ri...
Swapna Mohan,Patricia L Foley
Swapna Mohan
There have been recent efforts to reduce the administrative burden imposed on investigators. Although a complete and thorough review of proposed animal studies is an essential function of the Institutional Animal Care and Use Committee (IAC...
An Introduction to Pathology in Biomedical Research: A Mission-Critical Specialty for Reproducibility and Rigor in Translational Research [0.03%]
病理学在生物医学研究中的作用：提高转化研究可重复性和严谨性的关键学科
Cory F Brayton,Kelli L Boyd,Jeffrey L Everitt et al.
Cory F Brayton et al.
This issue of ILAR Journal focusses on pathology and pathologists in biomedical research, more specifically in preclinical translational research involving (nonhuman) animals, emphasizing academic settings. Considerations in study design an...
Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research [0.03%]
与免疫相关的和有免疫缺陷的小鼠：转化研究中的选择及机遇
Enrico Radaelli,Sara F Santagostino,Rani S Sellers et al.
Enrico Radaelli et al.
In 1989 ILAR published a list and description of immunodeficient rodents used in research. Since then, advances in understanding of molecular mechanisms; recognition of genetic, epigenetic microbial, and other influences on immunity; and ca...
Foreword and Introduction to This Issue on Contemporary Safety Topics in Animal Research [0.03%]
动物研究当代安全问题的本期预序言及介绍
John Bradfield,Esmeralda Meyer,John N Norton
John Bradfield
Institutions with animal care and use programs are obligated to provide for the health and well-being of the animals, but are equally obligated to provide for safety of individuals associated with the program. The topics in this issue of th...
Judy MacArthur Clark,Paula Clifford,Wendy Jarrett et al.
Judy MacArthur Clark et al.
Animals play a key role in biomedical research and other areas of scientific inquiry. But public opinion plays a key role in influencing how this area of science is regulated and funded. Nevertheless, scientists have historically been retic...
Dietary Factors in Prevention of Pediatric Escherichia coli Infection: A Model Using Domestic Piglets [0.03%]
预防儿童肠出血性大肠杆菌感染的膳食因素——利用仔猪模型进行的研究
Yanhong Liu,Peng Ji
Yanhong Liu
Enterotoxigenic Escherichia coli (ETEC) is the major etiological agent causing acute watery diarrhea that is most frequently seen in young children in lower-income countries. The duration of diarrheal symptom may be shortened by antibiotic ...
Keeping the Engine Running: The Relevance and Predictive Value of Preclinical Models for CAR-T Cell Development [0.03%]
CAR-T细胞开发的临床前模型的相关性和预测价值
Denis Migliorini,Nicola J Mason,Avery D Posey
Denis Migliorini
The cellular immunotherapy field has achieved important milestones in the last 30 years towards the treatment of a variety of cancers due to improvements in ex-vivo T cell manufacturing processes, the invention of synthetic T cell receptors...