Keith Reemtsma
Keith Reemtsma
Charles R. McCarthy
Charles R. McCarthy
William J. Karpus,Kevin J. Kennedy,Brian T. Fife et al.
William J. Karpus et al.
Experimental autoimmune encephalomyelitis (EAE) is a CD4+ Th1-mediated demyelinating disease of the central nervous system (CNS), which serves as a model for multiple schlerosis (MS). A hallmark in the pathogenesis of this disease is the em...
Use of Immunodeficient Mice for the Evaluation of CXC Chemokines in the Regulation of Tumor-associated Angiogenesis [0.03%]
免疫缺陷小鼠在肿瘤相关血管发生中CXC化学因子诱导的研究中的应用
Robert M. Strieter,Christina L. Addison,Jan E. Ehlert et al.
Robert M. Strieter et al.
Angiogenesis, defined as the growth of new capillaries from pre-existing vessels, is a pervasive biological phenomenon that is at the core of many physiologic and pathologic processes such as tumor growth. The use of human tumor xenografts ...
Role and Regulation of Chemokines in Rodent Models of Lung Inflammation [0.03%]
化学引诱素在肺炎症啮齿动物模型中的作用和调节
Boris J. Czermak,Hans P. Friedl,Peter A. Ward
Boris J. Czermak
Acute inflammatory lung injury has been induced in rats by intrapulmonary deposition of immunoglobulin G immune complexes or instillation of bacterial lipopolysaccaride. Several juxtaposed cysteine residue (CXC) chemokines (e.g., macrophage...
Emma M. Campbell,Nicholas W. Lukacs
Emma M. Campbell
Allergic airway inflammation is characterized by peribronchial eosinophil accumulation within the submucosa surrounding the airway. The development of appropriate animal models to dissect the critical mechanisms involved in the deleterious ...
Understanding the Pathogenesis of Inflammation Using Rodent Models: Identification of a Transcription Factor (NFkappaB) Necessary for Development of Inflammatory Injury [0.03%]
利用啮齿类动物模型理解炎症发病机制：鉴定出一个转录因子（NFkappaB）在炎症损伤发展中是必不可少的
Alex B. Lentsch,Peter A. Ward
Alex B. Lentsch
The acute inflammatory response is composed of a complex cascade of mediators, which facilitate the removal of infectious agents and restore normal tissue function. Experiments using cultured cells have demonstrated that the transcription f...
Matthew L. Steinhauser,Steven L. Kunkel,Cory M. Hogaboam
Matthew L. Steinhauser
Despite significant advances in the antibiotic arsenal and in intensive care unit technology, including mechanical ventilation, sepsis-related morbidity and mortality remain unacceptably high. Ultimately, 25 to 50% of all septic episodes en...
Timothy J. Brennan
Timothy J. Brennan
Even though it is a costly, poorly understood problem, very little effort has been dedicated toward research on the mechanisms of acute postoperative pain. Presumably, if we learn more about the etiology of acute incisional pain and the sen...
Models of Visceral Nociception [0.03%]
内脏痛觉模型
T.J. Ness
T.J. Ness
Pains arising from the viscera constitute a large portion of clinically treated pains. They are characterized by poor localization; immobility with tonic increases in muscle tone; and vigorous but nonspecific changes in autonomic function, ...