The Use of Arthropod-Borne Challenge Models in BSL-3Ag and BSL-4 Biocontainment [0.03%]
节肢动物传播的病原体在BSL-3AG和BSL-4实验室中使用的现状及未来展望
Stephen Higgs,Dana L Vanlandingham,Yan-Jang S Huang et al.
Stephen Higgs et al.
The study of many arthropod-borne pathogens requires high biosafety considerations, including the use of specialized facilities and equipment for arthropod containment. Mosquito- and tick-borne viruses such as yellow fever, West Nile, and C...
The Ferret as a Model for Filovirus Pathogenesis and Countermeasure Evaluation [0.03%]
刺突病毒致病性及防治措施评估的模式动物—— ferret模型
Zachary Schiffman,Guodong Liu,Wenguang Cao et al.
Zachary Schiffman et al.
The domestic ferret (Mustela putorius furo) has long been a popular animal model for evaluating viral pathogenesis and transmission as well as the efficacy of candidate countermeasures. Without question, the ferret has been most widely impl...
Rebecca T Veenhuis,Caroline J Zeiss
Rebecca T Veenhuis
Developing strong animal models is essential for furthering our understanding of how the immune system functions in response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. The alarming speed at which SARS-CoV-2 h...
High-Containment Agriculture Animal Research: An AAALAC International Perspective [0.03%]
农业动物研究中的高 containment问题：AAALAC国际协会的视角
Susan B Harper,Kathryn Bayne,Kenneth E Anderson
Susan B Harper
Institutions that conduct high-containment agricultural research involving domestic livestock represent a specialized category of programs that are accredited by AAALAC International. The accreditation process includes a comprehensive asses...
Animal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis [0.03%]
新冠肺炎动物模型.I.比较病毒学和疾病发病机制
Caroline J Zeiss,Susan Compton,Rebecca Terilli Veenhuis
Caroline J Zeiss
The Coronavirus Disease 2019 (COVID-19) pandemic has fueled unprecedented development of animal models to understand disease pathogenesis, test therapeutics, and support vaccine development. Models previously developed to study severe acute...
Research-Relevant Background Lesions and Conditions in Common Avian and Aquatic Species [0.03%]
常见鸟类和水生动物的与研究相关的背景病变和条件
Lisa M Mangus,Monique S França,H L Shivaprasad et al.
Lisa M Mangus et al.
Non-mammalian vertebrates including birds, fish, and amphibians have a long history of contributing to ground-breaking scientific discoveries. Because these species offer several experimental advantages over higher vertebrates and share ext...
IACUC and Veterinary Considerations for Review of ABSL3 and ABSL4 Research Protocols [0.03%]
关于ABSL3和ABSL4研究方案的IACUC和兽医考量因素审核
Curtis Klages
Curtis Klages
With the recent upswing of infectious disease outbreaks (coronavirus, influenza, Ebola, etc), there is an ever-increasing need for biocontainment animal use protocols to better address the research of emerging diseases and to increase the h...
Challenges and Opportunities in the Use of High and Maximum Biocontainment Facilities in Developing and Licensing Risk Group 3 and Risk Group 4 Agent Veterinary Vaccines [0.03%]
高致病性和最高生物安全设施在研发和注册三类及四类动物疫苗中的挑战与机遇
David A Brake,Jens H Kuhn,Glenn A Marsh et al.
David A Brake et al.
New solutions are necessary for the singular global health security threat formed by endemic, epidemic, and emerging/re-emerging zoonoses, coupled with epizootic and enzootic transboundary animal diseases (TADs). This One Health issue is re...
Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats [0.03%]
与须豪猪、犬、猪、羊和山羊相关的研究背景病变及疾病状况
Kristi L Helke,David K Meyerholz,Amanda P Beck et al.
Kristi L Helke et al.
Animal models provide a valuable tool and resource for biomedical researchers as they investigate biological processes, disease pathogenesis, novel therapies, and toxicologic studies. Interpretation of animal model data requires knowledge n...
Assisted Reproductive Techniques and Genetic Manipulation in the Common Marmoset [0.03%]
人工辅助繁殖技术在狨猴中的应用及基因操作
Jung Eun Park,Erika Sasaki
Jung Eun Park
Genetic modification of nonhuman primate (NHP) zygotes is a useful method for the development of NHP models of human diseases. This review summarizes the recent advances in the development of assisted reproductive and genetic manipulation t...