The Symbiotic Relationship Between Scientific Quality and Animal Research Ethics [0.03%]
科学研究质量与动物实验伦理的相互依存关系
Samuel A Brill,Selena M Guerrero-Martin,Kelly A Metcalf Pate
Samuel A Brill
Researchers have worked with animals as models for decades to expand our knowledge of basic biological processes and to systematically study the physiology of disease. In general, the public has an expectation that work with animals has a p...
A Brief History of Use of Animals in Biomedical Research and Perspective on Non-Animal Alternatives [0.03%]
实验动物的使用历史及非动物方法的前景展望
Lewis B Kinter,Ron DeHaven,David K Johnson et al.
Lewis B Kinter et al.
Animals have been closely observed by humans for at least 17 000 years to gain critical knowledge for human and later animal survival. Routine scientific observations of animals as human surrogates began in the late 19th century driven by i...
Kaela L Navarro,Monika Huss,Jennifer C Smith et al.
Kaela L Navarro et al.
There is an art and science to performing mouse anesthesia, which is a significant component to animal research. Frequently, anesthesia is one vital step of many over the course of a research project spanning weeks, months, or beyond. It is...
The Evaluation of the Containment Efficacy of Semi-Rigid Isolators for Housing Cages of Laboratory Animals Infected With BSL-3 Agents [0.03%]
三区实验室动物隔离器防护效果的评价研究报告
Louis DeTolla,David K Johnson,Scott D Reynolds et al.
Louis DeTolla et al.
Research animals models infected with Biosafety Level-3 (BSL-3) agents need to be housed in specialized biocontainment caging. Most of these specialized cages have input and exhaust that is high efficiency particulate air filtered and seale...
Type I Hypersensitivity in Ferrets Following Exposure to SARS-CoV-2 Inoculum: Lessons Learned [0.03%]
接触SARS-CoV-2疫苗后雪貂出现I型过敏反应：经验教训
Daniel Layton,Kathie Burkett,Glenn A Marsh et al.
Daniel Layton et al.
This case report discusses Type I hypersensitivity in ferrets following exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inoculum, observed during a study investigating the efficacy of candidate COVID-19 vaccines. Fo...
Case Reports
ILAR journal. 2021 Dec 31;62(1-2):232-237. DOI:10.1093/ilar/ilab019 2021
Chandra Saravanan,Thierry Flandre,Carolyn L Hodo et al.
Chandra Saravanan et al.
Biomedical research involving animal models continues to provide important insights into disease pathogenesis and treatment of diseases that impact human health. In particular, nonhuman primates (NHPs) have been used extensively in translat...
Biomonitoring and Digital Data Technology as an Opportunity for Enhancing Animal Study Translation [0.03%]
生物监测和数字数据技术作为提高动物研究转化的机会
Erwin B Defensor,Maria A Lim,Laura R Schaevitz
Erwin B Defensor
The failure of animal studies to translate to effective clinical therapeutics has driven efforts to identify underlying cause and develop solutions that improve the reproducibility and translatability of preclinical research. Common issues ...
Challenges and Solutions With Agricultural Animal High Containment Waste Disposal [0.03%]
农业动物高致病性废弃物处理面临的挑战及应对措施
John R Henneman,Julie A Johnson,Mark A Minihan
John R Henneman
Waste disposal in Agricultural Animal High Containment Animal Biosafety Level 3Ag and Animal Biosafety Level 4Ag (ABSL-3Ag and ABSL-4Ag) research facilities necessitates significantly more attention to detail in operations than that require...
Clinical Management of Gastrointestinal Disease in the Common Marmoset (Callithrix jacchus) [0.03%]
关于白面僧猴（Callithrix jacchus）胃肠疾病的临床治疗
Casey Fitz,Anna Goodroe,Lauren Wierenga et al.
Casey Fitz et al.
Gastrointestinal disease is a frequently encountered problem among captive common marmoset (Callithrix jacchus) colonies. Management can be challenging due to the number of etiologies responsible for gastrointestinal disease in this species...
Corinna N Ross,Ricki Colman,Michael Power et al.
Corinna N Ross et al.
The use of marmosets as nonhuman primate models of human disease has undergone rapid expansion in the United States in the last decade, with an emphasis in the field of neuroscience. With this expanding need, there has been an increase in t...