Famke Aeffner,Hibret A Adissu,Michael C Boyle et al.
Famke Aeffner et al.
Advancements in technology and digitization have ushered in novel ways of enhancing tissue-based research via digital microscopy and image analysis. Whole slide imaging scanners enable digitization of histology slides to be stored in virtua...
Of Mice, Dogs, Pigs, and Men: Choosing the Appropriate Model for Immuno-Oncology Research [0.03%]
鼠、狗、猪与人：免疫肿瘤学研究中选择合适的模型动物
Nana H Overgaard,Timothy M Fan,Kyle M Schachtschneider et al.
Nana H Overgaard et al.
The immune system plays dual roles in response to cancer. The host immune system protects against tumor formation via immunosurveillance; however, recognition of the tumor by immune cells also induces sculpting mechanisms leading to a Darwi...
A Review of Current Standards and the Evolution of Histopathology Nomenclature for Laboratory Animals [0.03%]
实验动物病理组织学名词的现状及发展方向综述
Susan A Elmore,Robert Cardiff,Mark F Cesta et al.
Susan A Elmore et al.
The need for international collaboration in rodent pathology has evolved since the 1970s and was initially driven by the new field of toxicologic pathology. First initiated by the World Health Organization's International Agency for Researc...
Agricultural Animals as Biomedical Models: Occupational Health and Safety Considerations [0.03%]
农业动物作为生物医学模型：职业健康与安全考量
Gaylen L Edwards,Michael J Azain,Andrew Parks
Gaylen L Edwards
The use of agricultural animals in biomedical research is increasing. Their overall size and metabolic rate, organ size, longer gestation period, and other physiological similarities make them good candidates for animal models of human dise...
Animal Models for Influenza A Virus Infection Incorporating the Involvement of Innate Host Defenses: Enhanced Translational Value of the Porcine Model [0.03%]
流感病毒动物模型研究中宿主先天免疫反应的参与：猪模型具有更高的转化价值
Sofie M R Starbæk,Louise Brogaard,Harry D Dawson et al.
Sofie M R Starbæk et al.
Influenza is a viral respiratory disease having a major impact on public health. Influenza A virus (IAV) usually causes mild transitory disease in humans. However, in specific groups of individuals such as severely obese, the elderly, and i...
Nontraditional Laboratory Animal Species (Cephalopods, Fish, Amphibians, Reptiles, and Birds) [0.03%]
非传统实验动物品种（头足类、鱼类、两栖动物、爬行动物和鸟类）
Dorcas P O&#x;Rourke,Cecile L Baccanale,Michael K Stoskopf
Dorcas P O&#x;Rourke
Aquatic vertebrates and cephalopods, amphibians, reptiles, and birds offer unique safety and occupational health challenges for laboratory animal personnel. This paper discusses environmental, handling, and zoonotic concerns associated with...
Beyond the H&E: Advanced Technologies for in situ Tissue Biomarker Imaging [0.03%]
超越HE染色：原位组织生物标志物成像的先进技术
Lauren E Himmel,Troy A Hackett,Jessica L Moore et al.
Lauren E Himmel et al.
For decades, histopathology with routine hematoxylin and eosin staining has been and remains the gold standard for reaching a morphologic diagnosis in tissue samples from humans and veterinary species. However, within the past decade, there...
Animal Models for Preclinical Development of Allogeneic Hematopoietic Cell Transplantation [0.03%]
异基因造血细胞移植的药效学动物模型
Scott S Graves,Maura H Parker,Rainer Storb
Scott S Graves
Since its inception in the 1950s, hematopoietic cell transplantation (HCT) has become a highly effective clinical treatment for malignant and nonmalignant hematological disorders. This milestone in cancer therapy was only possible through d...
Species Identity Supersedes the Dilution Effect Concerning Hantavirus Prevalence at Sites across Texas and México [0.03%]
TEXAS和MÉXICO各鼠种的汉他病毒带毒率高于局域尺度上的稀释效应
Matthew T Milholland,Iván Castro-Arellano,Elizabeth Arellano et al.
Matthew T Milholland et al.
Recent models suggest a relationship exists between community diversity and pathogen prevalence, the proportion of individuals in a population that are infected by a pathogen, with most inferences tied to assemblage structure. Two contrasti...
Brian C Gilger
Brian C Gilger
Ocular inflammatory diseases, such as dry eye and uveitis, are common, painful, difficult to treat, and may result in vision loss or blindness. Ocular side effects from the use of antiinflammatory drugs (such as corticosteroids or nonsteroi...