Pathology Study Design, Conduct, and Reporting to Achieve Rigor and Reproducibility in Translational Research Using Animal Models [0.03%]
动物模型转化医学研究的病理学设计、实施和报告以实现严谨性和重复性
Jeffrey I Everitt,Piper M Treuting,Cheryl Scudamore et al.
Jeffrey I Everitt et al.
In translational research, animal models are an important tool to aid in decision-making when taking potential therapies into human clinical trials. Recently, there have been a number of papers that have suggested limited concordance of pre...
Common Challenges in Safety: A Review and Analysis of AAALAC Findings [0.03%]
常见伦理问题及应对策略——基于AAALAC认证评审的分析
James R Swearengen
James R Swearengen
The 8th edition of the Guide for the Care and Use of Laboratory Animals (Guide) is clear in its requirement for each institution to establish and maintain an occupational health and safety (OHS) program as an essential part of the overall p...
Signe Tandrup Schmidt,Gabriel Kristian Pedersen,Dennis Christensen
Signe Tandrup Schmidt
Many different adjuvants are currently being developed for subunit vaccines against a number of pathogens and diseases. Rational design is increasingly used to develop novel vaccine adjuvants, which requires extensive knowledge of, for exam...
Kathryn Bayne,Patricia V Turner
Kathryn Bayne
Globalization of the biomedical research enterprise is occurring at an accelerating pace. Increasingly, scientific collaborations and contracts cross national borders. Assurance that the caliber of animal research and animal welfare are con...
Yohannes G Asfaw,Randall Reynolds,Scott Alderman et al.
Yohannes G Asfaw et al.
The procedures necessary to perform testing in a veterinary diagnostic laboratory have inherent associated risks to personnel in regard to exposure to infectious agents. In research institutions animals can be experimentally infected, acqui...
Good Laboratory Practice in the Academic Setting: Fundamental Principles for Nonclinical Safety Assessment and GLP-Compliant Pathology Support When Developing Innovative Biomedical Products [0.03%]
学术环境下的良好实验室规范（GLP）：在创新型生物医药产品研发过程中进行非临床安全性评估和符合GLP要求的病理学支持的基本原则
Brad Bolon,Wallace Baze,Christopher J Shilling et al.
Brad Bolon et al.
Development of new biomedical products necessitates nonclinical safety assessment in animals as a means of assessing potential risk to human patients. Pivotal nonclinical safety studies that support human clinical trials are performed accor...
Xenotransplantation: Progress Along Paths Uncertain from Models to Application [0.03%]
从模型到应用：异种移植的不确定性之路
Jeffrey L Platt,Marilia Cascalho,Jorge A Piedrahita
Jeffrey L Platt
For more than a century, transplantation of tissues and organs from animals into man, xenotransplantation, has been viewed as a potential way to treat disease. Ironically, interest in xenotransplantation was fueled especially by successful ...
Applied Institutional Approaches for the Evaluation and Management of Zoonoses in Contemporary Laboratory Animal Research Facilities [0.03%]
当代实验动物研究设施中的兽医公共卫生管理评估制度的实践与应用
Lesley A Colby,Lois Zitzow
Lesley A Colby
Zoonoses, diseases transmitted between animals and humans, have been a concern in laboratory animal medicine for decades. Exposure to zoonotic organisms not only poses health risks to personnel and research animals but may also affect resea...
In Vivo Imaging With Confirmation by Histopathology for Increased Rigor and Reproducibility in Translational Research: A Review of Examples, Options, and Resources [0.03%]
活体成像结合病理组织学验证以增强转化研究的严谨性和可重复性：举例、选择及资源综述
Kathleen Gabrielson,Robert Maronpot,Sébastien Monette et al.
Kathleen Gabrielson et al.
Preclinical noninvasive imaging can be an indispensable tool for studying animal models of disease. In vivo imaging to assess anatomical, functional, and molecular features requires verification by a comparison to the macroscopic and micros...
Jason S Villano,Susan E Vleck,Stephen A Felt et al.
Jason S Villano et al.
Research using laboratory animals has been revolutionized by the creation of humanized animal models, which are immunodeficient animals engrafted with human cells, tissues, or organs. These animal models provide the research community a uni...