Rebecca J Cox,Pauline Nol,Christine K Ellis et al.
Rebecca J Cox et al.
In fiscal year 2016, agricultural animals such as swine, sheep, goats, and cattle represented 10% of the 820 812 animals used in USDA-regulated research. In addition to traditional agricultural animals, research studies using captive wildli...
Investigator Engagement: Somewhat Radical Considerations on Practices to Improve Animal Care Program Compliance [0.03%]
有关改进动物照管项目遵从性的 somewhat radical实践的考虑意见——调查人员参与的角度
F Claire Hankenson,Troy Hallman
F Claire Hankenson
The authors discuss approaches to bolster investigator engagement, inviting investigators to be partners within the Animal Care Program. Regulatory burden in animal research endeavors continues to be reviewed and critiqued; therefore, this ...
Sue E Knoblaugh,Tobias M Hohl,Krista M D La Perle
Sue E Knoblaugh
Over 60% of NIH extramural funding involves animal models, and approximately 80% to 90% of these are mouse models of human disease. It is critical to translational research that animal models are accurately characterized and validated as mo...
Stuart E Leland,Pamela A Straeter,Beverly Jan Gnadt
Stuart E Leland
Institutional Animal Care and Use Committees (IACUCs) occasionally face regulatory requirements for which clear guidance may not be available. Either the regulating body has chosen not to provide such guidance or the guidance may be minimal...
Disaster Planning and Research Continuity in Responsible Animal Research [0.03%]
负责任的动物研究中的灾害应对和科研连续性
Nicolette Petervary,Jennifer K Pullium
Nicolette Petervary
Disaster preparedness for research facilities can be a daunting task. The purpose of this review is to introduce basic preparedness concepts and terminology so that facilities may begin to develop customized plans for their specific needs. ...
Gordon Roble,Jennifer Pullium,Takechia Hester et al.
Gordon Roble et al.
Disaster response planning for laboratory animal facilities is a time- and personnel-intensive undertaking. This article outlines numerous considerations in formulating a plan for disaster response in a high containment animal unit. The pla...
J M Wallace,R L Trundy
J M Wallace
Animal research pathology encompasses a wide array of procedures and may involve work with a variety of animal species and hazards. To protect laboratory personnel and ensure data integrity, pathologists must be familiar with the activities...
Fundamental Concepts for Semiquantitative Tissue Scoring in Translational Research [0.03%]
转化医学中半定量组织评分的基本概念
David K Meyerholz,Amanda P Beck
David K Meyerholz
Failure to reproduce results from some scientific studies has raised awareness of the critical need for reproducibility in translational studies. Macroscopic and microscopic examination is a common approach to determine changes in tissues, ...
Replacement, Refinement, and Reduction in Animal Studies With Biohazardous Agents [0.03%]
涉及生物危害剂动物实验中的替代、精简和减少策略
Lon V Kendall,James R Owiny,Erik D Dohm et al.
Lon V Kendall et al.
Animal models are critical to the advancement of our knowledge of infectious disease pathogenesis, diagnostics, therapeutics, and prevention strategies. The use of animal models requires thoughtful consideration for their well-being, as inf...
Clinical, Pathological, and Ethical Considerations for the Conduct of Clinical Trials in Dogs with Naturally Occurring Cancer: A Comparative Approach to Accelerate Translational Drug Development [0.03%]
自然发病犬癌症的临床试验的临床、病理和伦理考量：一种比较方法以加速药物转化发展
Daniel Regan,Kelly Garcia,Douglas Thamm
Daniel Regan
The role of comparative oncology in translational research is receiving increasing attention from drug developers and the greater biomedical research community. Pet dogs with spontaneous cancer are important and underutilized translational ...