Evaluation of the Long-Term Safety of Avacopan in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in the Real World (AvacoStar): Protocol for a Noninterventional Prospective Cohort Study [0.03%]
David R W Jayne,Raashid Luqmani,Benjamin Terrier et al.
David R W Jayne et al.
Background: Established treatments for granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) include the use of immunosuppressive agents for remission induction followed by maintenance therapy. However,...
Factors Influencing the Transition From Physiological Hyperopia to Myopia in Children: Protocol for a Prospective Nested Case-Control Study [0.03%]
Huaying Xu,Jianing Pu,Shimeng Bian et al.
Huaying Xu et al.
Background: The early onset of myopia in children has become a critical public health issue that requires urgent attention. Notably, high myopia-related retinal diseases have emerged as the leading cause of irreversible b...
Impact of Physiotherapy Intervention on Pain, Quality of Life, and Function in Low Back Pain Associated With Piriformis Syndrome: Protocol for Systematic Review [0.03%]
Nikita Deshmukh
Nikita Deshmukh
Background: Piriformis syndrome is a neuromuscular condition with hip and buttock pain and other symptoms, including referred pain towards the lower back and leg and radiating towards the foot's medial aspect. Similarly, ...
Managing Metabolic Dysfunction-Associated Steatotic Liver Disease: Protocol for a Scoping Review of Patient Perceptions, Barriers, and Facilitators [0.03%]
Sikyeong Park,Yu Shin Park,Dahye Hong et al.
Sikyeong Park et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is a major global health concern, affecting over 30% of adults worldwide. Closely a...
Mathematical Prediction Models for Sentinel Node Status in Early-Stage Breast Cancer: Protocol for a Systematic Review [0.03%]
Justin James,Kirti Mehta,Mohammadali Ahmadipour et al.
Justin James et al.
Background: The status of the axilla remains a significant prognostic factor and influences adjuvant systemic and locoregional treatment choices in early-stage breast cancer (EBC). Sentinel node (SN) biopsy continues to b...
HealthData@MAD-R&I: Protocol for Design and Development of a Regional Health Data Infrastructure to Enable Secondary Use of Health Data in Research and Innovation [0.03%]
Montserrat León-García,Sergio Álvarez-Pérez,Janire Gesto-Gómez et al.
Montserrat León-García et al.
Background: The exponential growth of electronic health records (EHRs), together with the recent entry into force of the European Health Data Space (EHDS) Regulation, highlights the urgent need for secure, interoperable e...
A Digital Intervention for Capturing Real-Time Health Data for Epilepsy Seizure Forecasting: Protocol for the ATMOSPHERE Study [0.03%]
Lauren Thompson,Emily Nielsen,Emily E V Quilter et al.
Lauren Thompson et al.
Background: Epilepsy is a chronic neurological disorder marked by recurrent and apparently unpredictable seizures and associated with premature death, injury, and diminished quality of life. The unpredictability of seizur...
Characterizing AIDS Drug Assistance Program (ADAP) Practices and Policies Contributing to Sustained Viral Suppression: Protocol for a Qualitative Assessment Guided by the Consolidated Framework for Implementation Research Framework [0.03%]
Kathleen A McManus,Erin Q Rogers,Amber Steen et al.
Kathleen A McManus et al.
Background: AIDS Drug Assistance Programs (ADAPs), a key part of the federally funded Ryan White HIV/AIDS Program (RWHAP), provide antiretroviral therapy (ART) to low-income and uninsured/underinsured people with HIV (PWH...
Integrating Physical Health Dimensions in Middle-Aged and Older Adults to Predict Drug Misuse and Relapse Through a Comprehensive Needs Model: Protocol for a Mixed Methods Study [0.03%]
Ema Madyaningrum,Eny Purwandary,Supriyati Supriyati et al.
Ema Madyaningrum et al.
Background: Drug misuse poses significant health risks, with rising prevalence globally, particularly affecting middle-aged and older adults. In Indonesia, drug misuse has complex impacts across physical, psychological, s...
Stella Namuganza,Mariacarla Gadebusch Bondio,Philipp Kellmeyer
Stella Namuganza
Background: The ethical, legal, and social issues accompanying the latest advancements in digital health technologies highlight the need to involve the public in their design, development, and deployment to align with soc...