Stromal cells as a part of tumor microenvironment of melanoma: Their role in cancer progression and drug resistance [0.03%]
肿瘤微环境中的间质细胞及其在癌症进展和药物抗性中的作用
Rafał Matkowski,Aleksandra Simiczyjew,Marcin Ziętek et al.
Rafał Matkowski et al.
Today, it is well established that the tumor microenvironment (TME), the tumor niche, along with melanoma cells, plays a crucial role in cancer dissemination and influences the effectiveness of anticancer therapies. Therefore, it may serve ...
Blood biomarkers of Alzheimer's disease: Balancing clinical relevance with improved accessibility and sustainability [0.03%]
阿尔茨海默病的血液生物标志物：兼顾临床意义和改善可及性与可持续性
Timothy Daly
Timothy Daly
The U.S. Food and Drug Administration (FDA) recently approved a blood-based biomarker to confirm diagnosis of Alzheimer's disease (AD-BBMs). When used in conjunction with human expertise in the diagnosis of neurocognitive disorder due to Al...
Access to services. Mental health in catastrophes and emergencies: Aspects [0.03%]
服务利用。灾祸和突发事件中的精神健康：一些方面
Sabine Bährer-Kohler
Sabine Bährer-Kohler
Disasters, wars and health emergencies profoundly affect mental health, with nearly 1/3 of affected populations developing conditions such as posttraumatic stress disorder (PTSD), depression or anxiety, particularly among vulnerable groups ...
Community-acquired pneumonia in HIV-infected patients: Updated insights on epidemiology and etiology [0.03%]
HIV感染患者的社区获得性肺炎：流行病学和病因的最新见解
Martyna Biała,Brygida Knysz
Martyna Biała
Bacterial pneumonia is a cause of HIV-associated morbidity and mortality. Recurrent pneumonia, defined as 2 or more episodes within a 12-month period, is an AIDS-defining illness. The prevalence of bacterial pulmonary infections in HIV-infe...
Neurobiological effects of childhood maltreatment: Health consequences, recovery pathways and clinical implications for holistic care [0.03%]
儿童虐待的神经生物学效应：健康后果、恢复途径及整体照护的临床意义
Yuko Hakamata,Hiroaki Hori
Yuko Hakamata
Adverse childhood experiences (ACEs), such as childhood abuse and neglect, have a profound impact on our bodies, affecting the brain, autonomic nervous system, endocrine system, immune and inflammatory systems, as well as genetic expression...
The efficacy of carfilzomib and dexamethason (Kd-70) as once-weekly two-drug regimen: The analysis of real-world data from Poland [0.03%]
卡非佐米与地塞米松(Kd-70)单周双药方案的疗效：波兰真实世界数据分析
Magdalena Olszewska-Szopa,Anna Czyż,Maria Węgrzyn et al.
Magdalena Olszewska-Szopa et al.
Background: The two-drug regimen Kd-70 (carfilzomib at a dose of 70 mg/m2 with dexamethasone) is a recommended treatment option for patients with relapsed or refractory multiple myeloma, according to both American and Eur...
Transcranial direct current stimulation (tDCS): A new, (still) legal form of "neurodoping" in sports? [0.03%]
经颅直流电刺激(tDCS)：一项新的（至今合法的）体育“神经兴奋剂”形式？
James Chmiel
James Chmiel
Transcranial direct current stimulation (tDCS) has emerged as a widely accessible, noninvasive technique capable of modulating cortical excitability. A rapidly expanding body of sports-science literature suggests that it can produce modest ...
HCV infection: Extrahepatic manifestations of infection and treatment options [0.03%]
HCV感染：感染的额外表现及治疗选择
Krzysztof Simon,Monika Pazgan-Simon
Krzysztof Simon
Currently, there is no doubt that hepatitis C virus (HCV) infection is a systemic disease affecting not only the liver but also a range of other organs - extrahepatic manifestations (EHMs). Extrahepatic manifestations usually occur concurre...
The correlation between nailfold capillaroscopic findings and adaptive optics imaging of retinal microvasculature in patients with systemic sclerosis [0.03%]
系统性硬化症患者指甲襞微循环与自适应光学眼底成像的相关性研究
Katarzyna Paczwa,Magdalena Szeretucha,Katarzyna Romanowska-Próchnicka et al.
Katarzyna Paczwa et al.
Background: Vascular injury is a central and early feature of systemic sclerosis (SSc) pathogenesis. Although nailfold capillaroscopy (NC) effectively visualizes characteristic peripheral arteriolar and capillary changes,...
Outcomes of the toe PIP joint transfer for IIIB hypoplastic thumb: Is it justified when pollicization is denied? [0.03%]
III型拇指发育不全不适合做大趾PIP关节移植术吗？该手术疗效如何？
Michał Górecki,Piotr Czarnecki,Ewa Bręborowicz et al.
Michał Górecki et al.
Background: Amputation followed by index finger pollicization is the gold-standard treatment for type III B thumb hypoplasia. However, despite its high success rate, some parents decline this procedure because it results ...