Myorelaxant and antispasmodic effect of an aqueous extract of Artemisia campestris L. via calcium channel blocking and anticholinergic pathways [0.03%]
Artemisia campestris L.水提取物的肌松和解痉作用通过钙通道阻滞和抗胆碱能通路产生
Mohamed Marghich,Ouafa Amrani,Hassane Mekhfi et al.
Mohamed Marghich et al.
Intestinal spasms are violent contractions that occur in the intestine, which cause discomfort to people who have them. Medicinal plants are widely used in traditional Moroccan medicine to treat these problems, among these being Artemisia c...
Giorgio Gabella
Giorgio Gabella
The characteristic mechanical activities of the smooth muscles found in all organs of the body are highly variable and depend mainly on the spatial arrangement of the muscle cells and the stroma: mass, orientation, relationships, links, con...
Angela L McCall,Justin S Dhindsa,Aidan M Bailey et al.
Angela L McCall et al.
Pompe disease is a lysosomal storage disease caused by mutations within the GAA gene, which encodes acid α-glucosidase (GAA)-an enzyme necessary for lysosomal glycogen degradation. A lack of GAA results in an accumulation of glycogen in ca...
Masashi Mukohda,Hiroshi Ozaki
Masashi Mukohda
This review highlights molecular mechanisms of anti-inflammatory and protective effects of the nuclear transcription factor, peroxisome proliferator-activated receptor γ (PPARγ) in vascular tissue. PPARγ is an ubiquitously expressed nucl...
The inhibitory effect of somatostatin on gastric motility in Suncus murinus [0.03%]
降钙素基因相关肽和生长抑素对仓鼠胃动力的作用及机制研究
Haruka Sekiya,Naho Yokota,Shota Takemi et al.
Haruka Sekiya et al.
Gastric contractions show two specific patterns in many species, migrating motor contractions (MMC) and postprandial contractions (PPCs), that occur in the fasted and fed states, respectively. In this study, we examined the role of somatost...
Satoshi Iino,Satomi Horiguchi,Kazuhide Horiguchi et al.
Satoshi Iino et al.
The c-Kit receptor tyrosine kinase regulates the development and differentiation of several progenitor cells. In the gastrointestinal (GI) tract, the c-Kit regulates the development of the interstitial cells of Cajal (ICC) that are responsi...
Diagnosis and treatments for oropharyngeal dysphagia: effects of capsaicin evaluated by newly developed ultrasonographic method [0.03%]
喉咽吞咽困难的诊断和治疗：新开发超声波方法评估辣椒素的效果
Rui Nakato,Noriaki Manabe,Kozo Hanayama et al.
Rui Nakato et al.
Oropharyngeal dysphagia (OD) is a common symptom in the older people, and may cause fatal complications such as aspiration pneumonia. However, there is no established treatment for OD. The relationship between the transient receptor potenti...
Physiological function and molecular composition of ATP-sensitive K+ channels in human gastric smooth muscle [0.03%]
人胃平滑肌ATP敏感性钾通道的生理功能及其分子组成
Sang Eok Lee,Dae Hoon Kim,Seung Myeung Son et al.
Sang Eok Lee et al.
Gastric motility is controlled by slow waves. In general, the activation of the ATP-sensitive K+ (KATP) channels in the smooth muscle opposes the membrane excitability and produces relaxation. Since metabolic inhibition and/or diabetes mell...
Accelerating effects of blebbistatin on relaxation process of cell membrane permeabilized trachea and taenia cecum from guinea pig [0.03%]
鬼笔环肽加快豚鼠去神经气管和结肠 taenia 松弛的作用效应
Satoko Mihashi,Yukisato Ishida,Masaru Watanabe
Satoko Mihashi
Blebbistatin, a potent inhibitor of myosin II, is known to suppress smooth muscle contraction without affecting myosin light chain phosphorylation level. In order to clarify the regulatory mechanisms of blebbistatin on phasic and tonic smoo...
Retsu Mitsui,Hikaru Hashitani
Retsu Mitsui
Spontaneous rhythmic constrictions known as vasomotion are developed in several microvascular beds in vivo. Vasomotion in arterioles is considered to facilitate blood flow, while venular vasomotion would facilitate tissue metabolite drainag...