Potential of the TRPM7 channel as a novel therapeutic target for pulmonary arterial hypertension [0.03%]
TRPM7通道作为肺动脉高压新型治疗靶点的潜力研究
Keizo Hiraishi,Lin Hai Kurahara,Kaori Ishikawa et al.
Keizo Hiraishi et al.
Pulmonary arterial hypertension (PAH) is an intractable vascular disease characterized by a progressive increase in pulmonary vascular resistance caused by pulmonary vascular remodeling, which ultimately leads to right-sided heart failure. ...
Glucose-6-phosphate dehydrogenase and MEG3 controls hypoxia-induced expression of serum response factor (SRF) and SRF-dependent genes in pulmonary smooth muscle cell [0.03%]
葡萄糖六磷酸脱氢酶和MEG3通过调控肺平滑肌细胞低氧诱导的血清应答因子（SRF）及SRF依赖型基因表达来发挥抗肺高血压作用
Atsushi Kitagawa,Christina Jacob,Sachin A Gupte
Atsushi Kitagawa
Although hypoxia induces aberrant gene expression and dedifferentiation of smooth muscle cells (SMCs), mechanisms that alter dedifferentiation gene expression by hypoxia remain unclear. Therefore, we aimed to gain insight into the hypoxia-c...
Possible roles of N- and C-terminal unstructured tails of CPI-17 in regulating Ca2+ sensitization force of smooth muscle [0.03%]
CPI-17的N端和C端无序尾部在调节平滑肌Ca2+敏感性力中的可能作用
Masumi Eto,Shuichi Katsuki,Minami Ohashi et al.
Masumi Eto et al.
CPI-17 regulates the myosin phosphatase and mediates the agonist-induced contraction of smooth muscle. PKC and ROCK phosphorylate CPI-17 at Thr38 leading to a conformational change of the central inhibitory domain (PHIN domain). The N- and ...
The TRPM8 channel as a potential therapeutic target for bladder hypersensitive disorders [0.03%]
TRPM8通道可能是膀胱高敏感性疾病潜在的治疗靶点
Naoki Aizawa,Tomoe Fujita
Naoki Aizawa
In the lower urinary tract, transient receptor potential (TRP) channels are primarily involved in physiological function, especially in cellular sensors responding to chemical and physical stimuli. Among TRP channels, TRP melastatin 8 (TRPM...
Disturbed gastric motility in patients with long-standing diabetes mellitus [0.03%]
糖尿病患者的胃电和胃动力异常研究
Takeshi Kamiya,Hidekatsu Fukuta,Hiromi Hagiwara et al.
Takeshi Kamiya et al.
Purpose: Gastric dysmotility has been reported in patients with long-standing diabetes mellitus (DM). Some patients with DM are diagnosed as diabetes gastroparesis and have several upper gastrointestinal (GI) symptoms suc...
Relationships between advanced glycation end products (AGEs), vasoactive substances, and vascular function [0.03%]
晚期糖基化终末产物（AGEs）、血管活性物质与血管功能之间的关系
Takayuki Matsumoto,Kumiko Taguchi,Tsuneo Kobayashi
Takayuki Matsumoto
Vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) are major cell types that control vascular function, and hence dysfunction of these cells plays a key role in the development and progression of vasculopathies. Abnormal vascu...
5-HT2A, 5-HT1B/D, 5HT3 and 5-HT7 receptors as mediators of serotonin-induced direct contractile response of bovine airway smooth muscle [0.03%]
血清素诱导的牛气道平滑肌直接收缩反应介质5-ht2a，5-ht1b/d，5ht3和5-ht7受体研究
Darwin Da Costa Guevara,Ernesto Trejo
Darwin Da Costa Guevara
Background: Serotonin (5-hydroxytryptamine; 5-HT) performs a variety of functions in the body including the modulation of muscle tone in respiratory airways. Several studies indicate a possible role of 5-HT in the pathoph...
Resistance of postprandial gastric functions and autonomic balance to taste stimulation [0.03%]
味觉刺激对餐后的胃部功能和自主神经平衡的耐受性研究
Marek Waluga,Anna Kasicka-Jonderko,Marek Dzielicki et al.
Marek Waluga et al.
Exposure to unpleasant tastes leads to disturbances of interdigestive gastric myoelectrical activity (GMA) and may affect sympathetic/parasympathetic balance (SPB). We made a careful study to determine whether taste stimulation modulates th...
Effect of acute sympathetic activation on leg vasodilation before and after endurance exercise [0.03%]
急性交感激活对耐力运动前后腿部血管舒张的影响
Alessandro Gentilin,Cantor Tarperi,Kristina Skroce et al.
Alessandro Gentilin et al.
Vascular conductance (VC) regulation involves a continuous balance between metabolic vasodilation and sympathetic vasoconstriction. Endurance exercise challenges the sympathetic control on VC due to attenuated sympathetic receptor responsiv...
Organ cross-sensitization mechanisms in chronic diseases related to the genitourinary tract [0.03%]
与生殖泌尿系统相关的慢性疾病的器官交叉敏感化机制
Tsuyoshi Majima,Naoto Sassa
Tsuyoshi Majima
There are various refractory chronic inflammatory diseases related to the genitourinary tract, such as interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome. It has been reported that in the genera...