Low-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes [0.03%]
低剂量华法林作为免疫调节剂预防环磷酰胺诱导的NOD糖尿病并发症
Midori Kurohara,Hisafumi Yasuda,Hiroaki Moriyama et al.
Midori Kurohara et al.
Warfarin has been used as an anticoagulant for a long time. Recently, the pleiotropic effect of warfarin has been investigated. As low-dose warfarin has been reported to have anti-inflammatory effect through suppression of IL-6 secretion an...
A simple interview-format screening measure for disaster mental health: an instrument newly developed after the 1995 Great Hanshin Earthquake in Japan--the Screening Questionnaire for Disaster Mental Health (SQD) [0.03%]
日本阪神大地震后简易的精神健康灾情筛选问卷（SQD）之发展：一种会谈式的筛检工具
Senta Fujii,Hiroshi Kato,Kiyoshi Maeda
Senta Fujii
Psychological intervention after a large-scale disaster requires an efficient and practical measure. Using self-reporting scale imposes certain limitations, especially when dealing with the elderly. It is also required that non-experts in m...
Acute effects of angiotensin II receptor blocker on ventricular repolarization alternans in chronic heart failure [0.03%]
血管紧张素II受体阻滞剂对慢性心力衰竭心室复极化变异性急性影响的研究
Shinya Kubo,Akihiro Yoshida,Hidetsuna Kitamura et al.
Shinya Kubo et al.
Repolarization alternans, which can be detected clinically as microvolt-level T-wave alternans (TWA), is considered an important mechanism underlying the initiation of ventricular tachycardia/ventricular fibrillation (VT/VF) linked to sudde...
Reversal effects of Ca2+ antagonists on multidrug resistance via down-regulation of MDR1 mRNA [0.03%]
钙拮抗剂逆转多药耐药及下调MDR1 mRNA的机制研究
Chiho Komoto,Tsutomu Nakamura,Motohiro Yamamori et al.
Chiho Komoto et al.
In previous reports, the effects of 12 Ca2+ antagonists on a multidrug resistant transporter, P-glycoprotein/MDR1, were evaluated in terms of those on MDR1-mediated transport of [3H]digoxin and the sensitivity of vinblastine sulfate or pacl...
Association of serum MCP-1 concentration and MCP-1 polymorphism with insulin resistance in Japanese individuals with obese type 2 diabetes [0.03%]
日本肥胖型2型糖尿病患者血清MCP-1浓度及MCP-1基因多态性与胰岛素抵抗的关系研究
Kunichi Kouyama,Kazuaki Miyake,Masako Zenibayashi et al.
Kunichi Kouyama et al.
Monocyte chemoattractant protein-1 (MCP-1, also known as CCL2) secreted by adipocytes is a member of the CC chemokine family and plays a pivotal role in the inflammatory process. A polymorphism, the -2518 A/G of MCP-1 gene, has been associa...
Three-dimensional, but not two-dimensional, culture results in tumor growth enhancement after exposure to anticancer drugs [0.03%]
三维但不是二维培养可增强肿瘤细胞对抗癌药物的反应
Chiho Komoto,Tsutomu Nakamura,Nobuko Ohmoto et al.
Chiho Komoto et al.
Previously, we have adapted a recently developed three-dimensional chemosensitivity test, the collagen gel droplet embedded culture drug sensitivity test (CD-DST), for evaluation of chemosensitivity of 12 anticancer drugs against colorectal...
Lack of association between the dopamine transporter gene 3' VNTR polymorphism and attention deficit hyperactivity disorder in Chinese Han children: case-control and family-based studies [0.03%]
注意缺陷多动障碍患儿DRD1基因多态性的病例对照及家系连锁研究
Yaping Wang,Zhaohui Wang,Kainan Yao et al.
Yaping Wang et al.
Attention deficit hyperactivity disorder (ADHD) is the most common childhood onset neurodevelopment disorder. The etiology is unclear, but is suspected to involve the dopamine system. In this study we used the haplotype-based haplotype rela...
Loss of CO2-induced distensibility in cerebral arteries with chronic hypertension or vasospasm after subarachnoid hemorrhage [0.03%]
慢性高血压或蛛网膜下腔出血后血管痉挛的脑动脉CO2反应性降低导致其顺应性缺失
Seiji Nakajima,Takeshi Kondoh,Akitsugu Morishita et al.
Seiji Nakajima et al.
We developed a rat cerebral angiography system using monochromatic synchrotron radiation X-rays at SPring-8, a third generation synchrotron radiation facility. Using new technique, we assessed the distensibility of major trunk arteries afte...
Methylglyoxal induces prostaglandin E2 production in rat mesangial cells [0.03%]
甲基乙二醛使大鼠系膜细胞产生前列腺素E2
Atsuko Uriuhara,Satoshi Miyata,Bing-Fen Liu et al.
Atsuko Uriuhara et al.
The formation of methylglyoxal (MG), a reactive dicarbonyl compound, is accelerated under hyperglycemia, presumably contributing to tissue injury in diabetes. On the other hand, prostaglandin E2 (PGE2) has been implicated in glomerular hype...
Intraocular pressure lowering effect of once daily versus once weekly latanoprost instillation in the same normal individuals [0.03%]
同一批正常人每日一次与每周一次拉坦前列素滴眼液的降眼压效果比较研究
Urtogtah Darhad,Makoto Nakamura,Miyuki Fujioka et al.
Urtogtah Darhad et al.
This study tested whether once weekly instillation of latanoprost exerts the similar IOP lowering effect as once daily instillation in the same individuals. Latanoprost was administered on right eyes of eight healthy male volunteers once da...
Clinical Trial
The Kobe journal of medical sciences. 2008 Feb 8;53(6):297-304. DOI: 2008