Ruka Echigo,Kazuki Nakao,Masahiro Fukaya et al.
Ruka Echigo et al.
We generated a versatile mouse line, L7-tTA knock-in mouse, in which tetracycline-responsive transcriptional activator (tTA) gene was introduced into exon 2 of L7 locus. Since L7 is specifically expressed in cerebellar Purkinje cells, we ex...
Role of angiotensin and the clock system in the circadian regulation of plasminogen activator inhibitor-1 [0.03%]
血管紧张素和钟控系统在纤溶酶原激活物抑制剂-1昼夜调节中的作用
Yoko Masuda,Noriaki Emoto,Hidemi Nonaka et al.
Yoko Masuda et al.
The clock system and the renin-angiotensin system (RAS) have been reported to play an important role in the circadian expression of plasminogen activator inhibitor-1 (PAI-1) gene. However, the degree of involvement of these systems remains ...
Compound elevated skull fracture with occlusion of the superior sagittal sinus. A case report [0.03%]
顶骨凹陷伴纵窦阻塞的颅骨复合型损伤一例报告
Khandaker Abu Talha,S Selvapandian,Khan Asaduzzaman et al.
Khandaker Abu Talha et al.
This is a case report of compound elevated skull fracture. This is a very rare variant of skull fractures. A CT angiogram demonstrated occlusion in the mid 1/3rd of superior sagittal sinus. Only few cases have been reported before. This pat...
Case Reports
The Kobe journal of medical sciences. 2009 Mar 24;54(5):E260-3. DOI: 2009
Qualitative and relative quantitative analysis of urinary components with linear ion trap and FT ICR mass spectrometer to search for biomarkers [0.03%]
采用线性离子阱和傅立叶变换ICR质谱对尿中成分进行定性和半定量分析以寻找生物标志物
Tomonori Takami,Shohei Shioyama,Kaori Fujii et al.
Tomonori Takami et al.
The purpose of the present study was to construct a method to identify varying amounts of urinary components between two groups. We measured urine acquired from 4 healthy men and 4 healthy women with a high performance liquid chromatograph-...
Comparative Study
The Kobe journal of medical sciences. 2009 Mar 11;54(5):E250-9. DOI: 2009
Diet-induced up-regulation of gene expression in adipocytes without changes in DNA methylation [0.03%]
饮食诱导的脂肪细胞基因表达上调而不改变DNA甲基化状态
Yuko Okada,Hiroshi Sakaue,Tomoki Nagare et al.
Yuko Okada et al.
The expansion of white adipose tissue (WAT) mass during the development of obesity is mediated in part through an increase in adipocyte size. Although gene expression profiles associated with adipogenesis in vitro and the development of obe...
Anterosuperior dislocation of the shoulder joint in an older patient with Parkinson's disease [0.03%]
帕金森氏病老年患者肩关节前上方脱位
Tokio Matsuzaki,Takeshi Kokubu,Issei Nagura et al.
Tokio Matsuzaki et al.
An 83-year-old woman, subsequently diagnosed with Parkinson's disease, fell on her right shoulder. Radiographs showed the humeral head dislocated anterosuperiorly. The supraspinatus tendon was massively disrupted and judged irreparable. The...
Case Reports
The Kobe journal of medical sciences. 2009 Mar 10;54(5):E237-40. DOI: 2009
HnRNP C1/C2 may regulate exon 7 splicing in the spinal muscular atrophy gene SMN1 [0.03%]
hnRNP C1/C2可能调节脊髓性肌肉萎缩症基因SMN1的外显子7的剪接事件
Sanae Irimura,Keiko Kitamura,Nozomu Kato et al.
Sanae Irimura et al.
Spinal muscular atrophy (SMA) is caused by loss of SMN1. A nearly identical gene, SMN2, fails to compensate for the loss of SMN1 because SMN2 produces mainly an exon 7-skipped product. The +6C in SMN1 exon 7 proceeds to include exon 7 into ...
Expression of beta-catenin and integrin-linked kinase in the mouse sciatic nerve [0.03%]
β-catenin和整合素连接激酶在小鼠坐骨神经的表达研究
Junichiro Takeuchi,Yasuyuki Shibuya,Maho Murata et al.
Junichiro Takeuchi et al.
In the present study, the expressions of beta-catenin and integrin-linked kinase (ILK) in the adult mouse peripheral nerve were investigated by means of immunoblotting analyses and electron microscopy using the immunogold pre -embedding met...
Insulin-stimulated fusion of GLUT4 vesicles to plasma membrane is dependent on wortmannin-sensitive insulin signaling pathway in 3T3-L1 adipocytes [0.03%]
wortmannin敏感的胰岛素信号途径调控3T3-L1脂肪细胞中GLUT4囊泡与质膜融合效应
Takayuki Kawaguchi,Yoshikazu Tamori,Mari Yoshikawa et al.
Takayuki Kawaguchi et al.
It is established that wortmannin which completely inhibits class IA PI 3-kinase activation abrogated the insulin-dependent translocation of GLUT4 to the plasma membrane in adipocytes and skeletal muscle. However, it was not clear which ste...
Shinichi Kinoshita,Wataru Ogawa,Yasuo Okamoto et al.
Shinichi Kinoshita et al.
Regulation of hepatic gene expression is largely responsible for the control of nutrient metabolism. We previously showed that the transcription factor STAT3 regulates glucose homeostasis by suppressing the expression of gluconeogenic genes...