Spinal Muscular Atrophy: Advanced Version of Screening System with Real-Time mCOP-PCR and PCR-RFLP for SMN1 Deletion [0.03%]
脊髓性肌萎缩症SMN1基因缺失的实时mCOP-PCR与PCR-RFLP联检体系研究
Emma Tabe Eko Niba,Mawaddah Ar Rochmah,Nur Imma Fatimah Harahap et al.
Emma Tabe Eko Niba et al.
Background: Spinal Muscular Atrophy (SMA) is a common autosomal recessive neuromuscular disease characterized by defects of lower motor neurons. More than 95% of SMA patients show homozygous deletion for the survival moto...
Spinal Muscular Atrophy: New Screening System with Real-Time mCOP-PCR and PCR-RFLP for SMN1 Deletion [0.03%]
脊髓性肌肉萎缩症：实时mCOP-PGR和PCR-RFLP检测SMN1基因缺失的筛查系统
Emma Tabe Eko Niba,Mawaddah Ar Rochmah,Nur Imma Fatimah Harahap et al.
Emma Tabe Eko Niba et al.
Background: Spinal Muscular Atrophy (SMA) is a common autosomal recessive neuromuscular disorder characterized by degeneration or loss of lower motor neurons. More than 95% of SMA patients show homozygous deletion for the...
The Novel Lipid-Lowering Drug D-47 Ameliorates Hepatic Steatosis and Promotes Brown/Beige-Like Change of White Adipose Tissue in db/db Mice [0.03%]
新型降脂药物D-47改善db/db小鼠肝脂肪变性及诱导白色脂肪组织褐变/米塔奇变化
Nao Mizusaki,Kazuhiro Nomura,Tetsuya Hosooka et al.
Nao Mizusaki et al.
D-47 is a newly developed solid dispersion of the arginine salt of (S)-(+)-4-[1-(4-tert-butylphenyl)-2-oxo-pyrrolidin-4-yl]methoxybenzoic acid (S-2E), which inhibits sterol and fatty acid synthesis. D-47 was recently shown to lower the seru...
Association Between HBx Variations and Development of Severe Liver Disease Among Indonesian Patients [0.03%]
HBx基因变异与印度尼西亚慢性乙型肝炎患者严重肝脏疾病发生的关系研究
Wahyu Aristyaning Putri,Yoshihiko Yano,Laura Navika Yamani et al.
Wahyu Aristyaning Putri et al.
Multi-site mutations in the hepatitis B virus (HBV) X gene are often found in patients with advanced liver diseases such as liver cirrhosis and hepatocellular carcinoma. It has been reported that modifications in the X protein play crucial ...
GC/MS and LC/MS-based Tissue Metabolomic Analysis Detected Increased Levels of Antioxidant Metabolites in Colorectal Cancer [0.03%]
基于GC/MS和LC/MS的结直肠癌组织代谢组学分析发现抗氧化代谢物水平升高
Megumi Kibi,Shin Nishiumi,Takashi Kobayashi et al.
Megumi Kibi et al.
Late-stage colorectal cancer is resistant to current treatments. Understanding the biological processes responsible for the development and progression of colorectal cancer could aid the development of new diagnostic and treatment approache...
Role of Hypoxia Inducible Factor-1 Alpha (HIF-1α) in Cytoglobin Expression and Fibroblast Proliferation of Keloids [0.03%]
缺氧诱导因子-1α对瘢痕疙瘩成纤维细胞增殖及细胞青素表达的影响
Sri Widia A Jusman,Dewi Hambar Sari,Sri Suciati Ningsih et al.
Sri Widia A Jusman et al.
Background: Keloids are characterized by an overabundance of collagen deposition due to elevated activity and proliferation of fibroblasts, which lead to hypoxic conditions. Adaptation to these conditions is regulated by ...
CD44v8-10 and CD44s Are Age-dependently Expressed in Primary Cultured Papillary Thyroid Carcinoma Cells and Are Associated with Cell Proliferation [0.03%]
CD44v8-10和CD44s在甲状腺乳头状癌原代细胞系中的表达及其与增殖活性的相关性年龄相关性研究
Takeo Kawai,Keisuke Iwata,Yuna Shinotsuka et al.
Takeo Kawai et al.
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy, arising from follicular cells, and accounts for more than 80% of all thyroid malignant tumors. Although age is the strongest prognostic factor of PTC, and various cu...
Red LED Light Is Influenced by IL-6 to Promote the Migration Ability of Oral Squamous Cell Carcinoma Cell Line [0.03%]
红光通过影响白细胞介素-6促进口腔鳞状细胞癌迁移能力
Kenji Matsuo,Hiroaki Suzuki,Nanae Yatagai et al.
Kenji Matsuo et al.
Aim: The purpose of this study was to search for the influence of red LED light of oral squamous cell carcinoma cells (OSCC) Material & Methods: HSC-3 was irradiated with red LED light (630 nm/3 J). Proliferative capacity...
Regulation of Small Intestinal Epithelial Homeostasis by Tsc2-mTORC1 Signaling [0.03%]
Tsc2-mTORC1信号通路调节小肠上皮稳态
Jajar Setiawan,Takenori Kotani,Tasuku Konno et al.
Jajar Setiawan et al.
Mammalian target of rapamycin complex 1 (mTORC1), a protein complex containing the serine/threonine kinase mTOR, integrates various growth stimulating signals. mTORC1 is expressed in intestinal epithelial cells (IECs), whereas the physiolog...
Mizuki Uenaka,Mayumi Morizane,Kenji Tanimura et al.
Mizuki Uenaka et al.
Antibodies against fetal platelet alloantigens in maternal blood cause neonatal alloimmune thrombocytopenia (NAIT). We encountered four newborns with NAIT from three women. A woman carried anti-human platelet antigen (HPA)-1a antibody, and ...
Case Reports
The Kobe journal of medical sciences. 2019 Mar 5;64(6):E197-E199. DOI: 2019