Parallel molecular alteration between Alzheimer's disease and major depressive disorder in the human brain dorsolateral prefrontal cortex: an insight from gene expression and methylation profile analyses [0.03%]
基于基因表达和甲基化谱分析的人脑背外侧前额叶皮层在阿尔茨海默病和抑郁症中的并行分子改变机制的初步探索
Saber Rastad,Nadia Barjaste,Hossein Lanjanian et al.
Saber Rastad et al.
Alzheimer's disease (AD) and major depressive disorder (MDD) are comorbid neuropsychiatric disorders that are among the leading causes of long-term disability worldwide. Recent research has indicated the existence of parallel molecular mech...
Identification of genes regulating stimulus-dependent synaptic assembly in Drosophila using an automated synapse quantification system [0.03%]
利用自动化突触定量系统在果蝇中鉴定调节刺激依赖性突触装配的基因
Jiro Osaka,Haruka Yasuda,Yusuke Watanuki et al.
Jiro Osaka et al.
Neural activity-dependent synaptic plasticity is an important physiological phenomenon underlying environmental adaptation, memory and learning. However, its molecular basis, especially in presynaptic neurons, is not well understood. Previo...
Analysis for drug metabolism-related prognostic subtypes and gene signature in liver cancer [0.03%]
肝癌的药物代谢相关预后亚型及基因特征分析
Yue Zhang,Jun Chen,Chengru Hu et al.
Yue Zhang et al.
Liver cancer is highly heterogeneous and has a poor prognosis. We aimed to identify a drug metabolism-related prognostic subtype and a gene signature as references for prognosis and therapy options for patients with liver cancer. Patient in...
Mei Hattori,Chihiro Horigome,Théo Aspert et al.
Mei Hattori et al.
Genome instability is a major cause of aging. In the budding yeast Saccharomyces cerevisiae, instability of the ribosomal RNA gene repeat (rDNA) is known to shorten replicative lifespan. In yeast, rDNA instability in an aging cell is associ...
Detection and analysis of chemical-induced chromosomal damage for public health: integrating new approach methodologies and non-animal methods [0.03%]
基于公共健康的化学致染色体损伤的检测与分析：整合新方法学和非动物法
Yurika Fujita,Hiroshi Honda
Yurika Fujita
Chromosomal damage occurs both endogenously and exogenously and is a crucial factor in the induction of carcinogenesis. Chemically induced chromosomal damage is mainly exogenous. The OECD has developed methods to detect chemicals that induc...
Naoyuki Takahata,Hirotaka Sugawara
Naoyuki Takahata
The role played by error catastrophe is explicitly taken into account in a mathematical formulation to analyze COVID-19 data. The idea is to combine the mathematical genetics formalism of the error catastrophe of mutations in virus gene loc...
Lotus japonicus NLP1 and NLP4 transcription factors have different roles in the regulation of nitrate transporter family gene expression [0.03%]
莲花日本种NLP1和NLP4转录因子在硝酸盐转运蛋白家族基因表达调控中的作用不同
Hanna Nishida,Takuya Suzaki
Hanna Nishida
Root nodule symbiosis is promoted in nitrogen-deficient environments, whereas host plants cease the symbiosis if they can obtain enough nitrogen from their surrounding soil. In Lotus japonicus, recent reports indicate that two NODULE INCEPT...
Optimization of nucleic acid extraction and amplification of a thiamine biosynthesis gene fragment from selected Malaysian seaweeds [0.03%]
马来西亚选海藻中核苷酸提取和维生素B1生物合成基因片段扩增的优化
Fatin Amira Md Ahaik,Siti Hajar Mohd Taufik,Nur Asna Faiqah Johari et al.
Fatin Amira Md Ahaik et al.
Obtaining high-quality nucleic acid extracted from seaweeds is notoriously difficult due to contamination with polysaccharides and polyphenolic compounds after cell disruption. Specific methods need to be employed for RNA isolation in diffe...
Isolation of Pikps, an allele of Pik, from the aus rice cultivar Shoni [0.03%]
从水稻品种Shoni中分离出Pik的等位基因Pikps
Basavaraj Kovi,Toshiyuki Sakai,Akira Abe et al.
Basavaraj Kovi et al.
Blast disease caused by the filamentous fungus Pyricularia oryzae (syn. Magnaporthe oryzae) is one of the most destructive diseases of rice (Oryza sativa L.) around the globe. An aus cultivar, Shoni, showed resistance against at least four ...