Development of an isogenic human cell trio that models polyglutamine disease [0.03%]
开发一个模拟多聚谷氨酰胺疾病的同基因人类细胞三联体
Tomoyuki Ohno,Takeshi Nakane,Taichi Akase et al.
Tomoyuki Ohno et al.
Polyglutamine (polyQ) diseases are rare autosomal-dominant neurodegenerative diseases associated with the expansion of glutamine-encoding triplet repeats in certain genes. To investigate the functional influence of repeat expansion on disea...
Comprehensive analysis of m6A modifications in oral squamous cell carcinoma by MeRIP sequencing [0.03%]
口腔鳞癌中m6A修饰的MeRIP测序分析
Yang Liu,Huiqing Long,Xiaogang Zhong et al.
Yang Liu et al.
N6-methyladenosine (m6A) modifications are the most abundant internal modifications of mRNA and have a significant role in various cancers; however, the m6A methylome profile of oral squamous cell carcinoma (OSCC) in the mRNA-wide remains u...
Keisuke Mase,Chikara Hirayama,Junko Narukawa et al.
Keisuke Mase et al.
Some strains of silkworms produce green cocoons of varying intensities. This results from quantitative and qualitative differences in flavonoid pigments, which are influenced by the environment and genetic background. We discovered that the...
Translation of paired box 6 (PAX6) mRNA is IRES-mediated and inhibited by cymarin in breast cancer cells [0.03%]
配对盒6(PAX6)mRNA在乳腺癌细胞中的翻译由IRES介导并被cymarin抑制
Qi Li,Xiao Liu,Yun Xu et al.
Qi Li et al.
Paired box 6 (PAX6) is a member of the PAX family and plays an essential role in cancer cell cycle progression, colony formation, proliferation and invasion. Its expression is upregulated in many cancers including breast cancer, but the pro...
Expression profiles in knock-down transgenic plants of high and low diversified duplicate genes in Arabidopsis thaliana [0.03%]
拟南芥高可变性和低可变性分化 duplicated 基因的敲除系表达谱分析
Tomoyuki Takeda,Akihiro Ezoe,Kousuke Hanada
Tomoyuki Takeda
Duplicated genes show various degrees of functional diversification in plants. We previously identified 1,052 pairs of high diversified duplicates (HDDs) and 600 pairs of low diversified duplicates (LDDs) in Arabidopsis thaliana. Single kno...
Testing immediate dosage compensation in Drosophila miranda via irradiation with heavy-ion beams [0.03%]
用重离子束照射测试黑腹果蝇剂量补偿的即时检验
Masafumi Ogawa,Kazuhide Tsuneizumi,Tomoko Abe et al.
Masafumi Ogawa et al.
Many organisms with heteromorphic sex chromosomes possess a mechanism of dosage compensation (DC) in which X-linked genes are upregulated in males to mitigate the dosage imbalance between sexes and between chromosomes. However, how quickly ...
Development and characterization of expressed sequence tag-simple sequence repeat markers for Anaphalis margaritacea var. yedoensis (Asteraceae) [0.03%]
牻牛儿苗属边缘花亚种序标签-简单重复序列标记的开发和特征描述
Taishi Hoson,Shoki Murakami,Takuro Ito et al.
Taishi Hoson et al.
RNA-sequencing was used to develop 16 microsatellite markers for the pearly everlasting, Anaphalis margaritacea var. yedoensis (Franch. et Sav.) Ohwi (Asteraceae), which inhabits gravel bars throughout the Japanese archipelago. The mean num...
A new variant of the ectodysplasin A receptor death domain gene associated with anhidrotic ectodermal dysplasia in a Turkish family and its simple diagnosis by restriction fragment length polymorphism [0.03%]
土耳其一家的无汗性外胚叶发育不良死亡域基因新突变及简单的限制片段长度多态性诊断方法
Eyyup Rencuzogullari,Banu Guven Ezer
Eyyup Rencuzogullari
Ectodermal dysplasia (ED), which exhibits a wide range of clinical symptoms, may be classified into three major types: hypohidrotic, anhidrotic, and hidrotic. A male child (proband) showing anhidrotic dysplasia was used as the subject of th...
Junko Kanoh
Junko Kanoh
Eukaryotic cells contain multiple types of duplicated sequences. Typical examples are tandem repeat sequences including telomeres, centromeres, rDNA genes and transposable elements. Most of these sequences are unstable; thus, their copy num...