A Catalog of the Pathogenic Variants in ABCG5 and ABCG8 and Clinical Features in Sitosterolemia [0.03%]
ABCG5和ABCG8病原变异目录及植物固醇血症的临床特征
Takeshi Okada,Shizuya Yamashita,Hayato Tada et al.
Takeshi Okada et al.
Aim: Since comprehensive data on the pathogenic variants of ABCG5 and ABCG8 and clinical features in sitosterolemia remain limited, we aimed to compile a catalog through an extensive literature search of case reports from...
The Effects of Pemafibrate on Fibrinogen and Thrombogenicity in Patients with Coronary Artery Disease [0.03%]
贝玛普利斯特对冠状动脉疾病患者纤维蛋白原及促凝血因子的影响
Masanobu Ishii,Koichiro Fujisue,Koichi Kaikita et al.
Masanobu Ishii et al.
Aims: Pemafibrate effectively reduces the triglyceride levels in patients with coronary artery disease (CAD). However, its effect on the fibrinogen levels in these patients remains unclear. This study aimed to investigate...
TLR4 Inhibition Attenuates Vascular Remodeling in A Mouse Model of Chronic Kidney Disease [0.03%]
TLR4抑制减轻慢性肾脏病小鼠模型中的血管重塑
Tomohiro Shirouzu,Jun-Ichiro Koga,Nasanbadrakh Orkhonselenge et al.
Tomohiro Shirouzu et al.
Aim: Chronic kidney disease (CKD) is linked to accelerated vascular remodeling, characterized by medial thickening and fibrosis; however, the molecular mechanisms driving this process remain unclear. ...
An Elevated Serum Apolipoprotein C-III Concentration is Associated with the Risk of Coronary Heart Disease in a Japanese General Population. The Hidaka Cohort Study [0.03%]
日本一般人群APOC-Ⅲ与冠心病发病风险的关系——日多道群组研究
Yoshio Fujioka,Shin-Ichiro Tanaka,Takeshi Tsujino et al.
Yoshio Fujioka et al.
Aim: Apolipoprotein CIII (ApoC-III) is a lipid-associated protein crucial for the lipid metabolism. Recent studies have shown that ApoC-III also plays a role in vascular dysfunction and the development of coronary heart d...
The Dietary Fiber Intake and the Risk of Disabling Dementia: The JPHC Disabling Dementia Study [0.03%]
膳食纤维摄入与痴呆风险的关系：JPHC队列研究中的致残性痴呆研究结果
Shoko Aoki,Kazumasa Yamagishi,Isao Muraki et al.
Shoko Aoki et al.
Aim: We evaluated the association between the dietary fiber intake and the risk of dementia. Methods: We performed a prospective study ...
PGC-1β Mediates the Atheroprotective Roles of β-Aminoisobutyric Acid (BAIBA) in Vascular Endothelial Cells [0.03%]
β-氨基异丁酸(BAIBA)的血管内皮细胞护动脉作用机制研究及其与PGC-1β的关系
Hiroyasu Yamamoto,Ayano Ishii,Shinji Kihara
Hiroyasu Yamamoto
Aims: Physical exercise exerts antiatherosclerotic effects through several mechanisms. One anti-inflammatory effect of exercise is directly exerted on vascular endothelial cells by β-aminoisobutyric acid (BAIBA), which i...
Inverse Association between T50 Calciprotein Crystallization (Serum Calcification Propensity) and Carotid Artery Intima-Media Thickness in Health Examinees with a Reduced Kidney Function [0.03%]
肾功能下降受检者中血钙化倾向（T50）与颈动脉内膜-中膜厚度的负相关性研究
Yu Nagakura,Tetsuo Shoji,Shinya Fukumoto et al.
Yu Nagakura et al.
Aim: T50 is the time required for primary calciprotein particles (CPPs) to transform into secondary CPPs in vitro, reflecting serum calcification propensity, and used as a biomarker for calcification stress. Since seconda...
The Blockade of Delta-Like Ligand 1 Inhibits Atherosclerotic Lesion Formation and Attenuates Plaque Vulnerability [0.03%]
阻断Delta样配体1抑制动脉粥样硬化病变形成并降低斑块易损性
Nasanbadrakh Orkhonselenge,Jun-Ichiro Koga,Daiki Kakumori et al.
Nasanbadrakh Orkhonselenge et al.
Aim: Notch signaling is a fundamental signal that regulates morphogenesis and cell differentiation during the embryonic period, and it plays a crucial role in macrophage differentiation. Macrophage-mediated inflammation p...
Higher Small Dense LDL Cholesterol to LDL Cholesterol Ratio is Associated with Glomerular Hyperfiltration in Adults without Diabetes [0.03%]
小而致密LDL胆固醇与总LDL胆固醇比值较高与非糖尿病成人肾葡萄糖过度过滤有关
Nobuhisa Morimoto,Yasushi Yamamoto,Ryoko Toragai et al.
Nobuhisa Morimoto et al.
Aims: While glomerular hyperfiltration (GHF) emerged as a risk factor for cardiovascular disease (CVD), little is known about the association between GHF and blood lipid profile. We aimed to examine the association betwee...