Association between cardiovascular disease risk factors and white matter lesions: The Tohoku Medical Megabank Cohort Study [0.03%]
日本东北医学megabank队列研究中血管风险因素与白质病变的关系
Megumi Satake,Ippei Chiba,Mana Kogure et al.
Megumi Satake et al.
Aim: White matter lesions (WML) are associated with dementia and they are influenced by cardiovascular disease (CVD) risk factors. Managing these risk factors may prevent WML progression. However, few longitudinal studies...
Association of Relative LDL-Cholesterol Reduction With Cardiovascular Outcomes After Percutaneous Coronary Intervention [0.03%]
血运重建术后低密度脂胆固醇相对降幅与心血管预后的关联性分析
Tetsuji Morishita,Hiroyasu Uzui,Yusuke Sato et al.
Tetsuji Morishita et al.
Aim: Intensive low-density lipoprotein cholesterol (LDL-C) lowering is a cornerstone of secondary prevention after percutaneous coronary intervention (PCI). Although most evidence has focused on achieved LDL-C levels, the...
The Tortuosity of Middle Cerebral Artery is Associated with Ipsilateral Recurrence of Ischemic Events [0.03%]
中脑动脉曲度与同侧缺血事件复发的相关性研究
Yuan Chen,Yifan Wang,Yanan Zhu et al.
Yuan Chen et al.
Aim: To investigate whether the tortuosity of the culprit middle cerebral artery (MCA) is correlated with the recurrence of ipsilateral ischemic events in patients with ischemic stroke caused by intracranial atherosclerot...
Lipoprotein(a) Is Associated with Coronary Plaque Vulnerability and Compensatory Vascular Enlargement: An Intravascular Ultrasound Study [0.03%]
脂蛋白(a)与冠脉斑块脆弱性及血管代偿性重构的相关性——血管内超声研究
Yufeng Jiang,Jie Lin,Mingyu Ma et al.
Yufeng Jiang et al.
Aims: Lipoprotein(a) [Lp(a)] has emerged as a critical determinant of residual cardiovascular risk. However, its impact on plaque morphology remains underinvestigated. This study aimed to elucidate the relationship betwee...
Ligand-Specific Notch Signaling in Atherosclerosis: Implications for Inflammation and Plaque Stability [0.03%]
动脉粥样硬化中的配体特异性Notch信号通路：对炎症和斑块稳定性的意义
Oyunbileg Bavuu,Daiju Fukuda
Oyunbileg Bavuu
Clinical Efficacy with Evolocumab among Japanese Patients in PROFICIO: A Pooled Analysis of 1,040 Patients [0.03%]
PROFICIO研究中的东亚患者亚组中Evolocumab临床疗效分析：基于1040例患者的 pooled 分析
Kazuma Oyama,Masayuki Yoshida,Arihiro Kiyosue et al.
Kazuma Oyama et al.
Aims: Lowering low-density lipoprotein cholesterol (LDL-C) is essential for reducing the risk of atherosclerotic cardiovascular disease (ASCVD). This study assessed the clinical efficacy of evolocumab, a human monoclonal ...
Role of T1-weighted MRI in Identifying Coronary Intraplaque Hemorrhage: CATCH the Truly High-Risk Plaque [0.03%]
T1加权磁共振成像识别冠状动脉斑块内出血的价值：识别真正高危斑块
Hidenari Matsumoto
Hidenari Matsumoto
Intraplaque hemorrhage (IPH) is a key feature of plaque vulnerability that contributes to atherothrombotic events. Non-invasive coronary plaque imaging has been challenging because of the small size of the coronary arteries and motion cause...
Switching from Conventional Fibrates to Pemafibrate Improves Lipid Profiles, Liver Enzymes, Renal Function, and Fibrosis Markers in Dyslipidemic Patients with MASLD: A Multicenter Real-World Study [0.03%]
从传统贝特类药物转换为Pemafibrate可改善MASLD血脂异常患者的血脂谱、肝酶、肾功能和纤维化标志物：一项多中心真实世界研究
Takao Sato,Toshihiro Miyamoto,Ryoma Fukuoka et al.
Takao Sato et al.
Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent worldwide. Conventional fibrates effectively lower triglycerides but may elevate liver enzymes and creatinine, limiting long-term ...
Beyond Conventional Imaging: From Time-Based to Data-Driven Decision-Making in Acute Ischemic Stroke [0.03%]
超越传统影像：急性缺血性卒中的决策模式转变——从时间驱动到数据驱动
Ichiro Deguchi,Junya Aoki
Ichiro Deguchi
Reperfusion therapy has profoundly transformed acute ischemic stroke (AIS) care. Initially, treatment decisions relied primarily on time from symptom onset. However, growing evidence has shown that the extent of irreversibly injured tissue ...
Impact of High-Intensity Statins and Low-Density Lipoprotein Cholesterol on the Outcomes of Coronary Intervention for Chronic Coronary Syndrome in Japan [0.03%]
高强度他汀和低密度脂蛋白胆固醇对日本慢性冠状动脉综合征患者冠脉介入治疗预后影响的多中心研究
Yohei Yamauchi,Yumiko Kanzaki,Daisuke Shishikura et al.
Yohei Yamauchi et al.
Aim: The clinical effect of high-intensity statin therapy after percutaneous coronary intervention (PCI) in Japanese patients with chronic coronary syndrome (CCS) remains unclear. We investigated the association between h...