Hayato Tada,Kenji Sakata,Soichiro Usui et al.
Hayato Tada et al.
LDL cholesterol (LDL-C) is the central causal factor for atherosclerotic cardiovascular disease (ASCVD), and its reduction is a cornerstone of both primary and secondary prevention. Since the introduction of statins more than three decades ...
Liver Dysfunction Assessed by Albumin - Bilirubin (ALBI) Score is Associated with Disturbed Cholesterol Profiles and Reduced Survival in Patients with Chronic Limb-Threatening Ischemia [0.03%]
由血液白蛋白-胆红素（ALBI）评分评估的肝功能障碍与慢性缺血性下肢病变患者的血脂代谢紊乱和生存率降低相关
Kentaro Inoue,Shinichiro Yoshino,Yutaka Matsubara et al.
Kentaro Inoue et al.
Aims: Liver dysfunction may affect chronic limb-threatening ischemia (CLTI) outcomes, but its impact on survival and lipid profiles is unclear. To assess the association of liver dysfunction using the Albumin-Bilirubin (A...
Perspectives on Bempedoic Acid, ATP-citrate lyase inhibitor: Targeting Lipid Metabolism and Inflammation [0.03%]
贝梅普渡酸是一种ATP-柠檬酸裂解酶抑制剂：靶向脂质代谢和炎症的见解
Ryuki Kitamoto,Yuki Morikawa-Isogai,Hitoshi Shimano
Ryuki Kitamoto
Bempedoic acid is a novel oral low-density lipoprotein cholesterol (LDL-C)-lowering agent that selectively inhibits ATP-citrate lyase (ACL), an enzyme located upstream of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in the chol...
Cross-Sectional Association of Lipoprotein(a) Levels With Vascular Complications and Related Parameters in a Japanese Type 2 Diabetes Cohort [0.03%]
日本2型糖尿病患者中脂蛋白(a)水平与血管并发症及有关参数的横断面分析
Tsutomu Hirano,Mayumi Uetani,Kento Nakata et al.
Tsutomu Hirano et al.
Aims: To investigate the association between Lipoprotein(a) (Lp(a)) levels and vascular complications, as well as related parameters, in a cohort of Japanese patients with type 2 diabetes. ...
Association Between Plasma Omega-3 and Omega-6 Fatty Acid Levels and Atrial Fibrillation: A Large-Scale, Real-World Retrospective Study in Japan [0.03%]
日本大规模真实世界回顾性研究中的血浆欧米茄-3及欧米茄-6脂肪酸与心房颤动的关联性分析
Naotake Yanagisawa,Kazutoshi Fujibayashi,Tetsuro Miyazaki et al.
Naotake Yanagisawa et al.
Aim: The relationship between omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) and atrial fibrillation (AF) remains unclear. This retrospective study aimed to investigate the association between plasma levels of om...
Hospital Course and Outcomes After Major Bleeding in Patients on Factor Xa Inhibitors in Japan: A Nationwide Observational Study [0.03%]
日本Xa抑制剂治疗患者大出血的住院经过及预后：全国性观察研究
Shun Kohsaka,Masahiro Yasaka,Mitsuru Hoshino et al.
Shun Kohsaka et al.
Aim: To evaluate the clinical characteristics, management, and in-hospital outcomes of patients hospitalized with major bleeding while receiving direct factor Xa inhibitors (FXa-I) using a large-scale, nationwide administ...
A Literature Review on the Waist Circumference Criteria for Metabolic Syndrome in Japan: Evidence and Implications for Cardiovascular Risk Stratification [0.03%]
日本代谢综合征腰围切点的文献回顾：心血管风险分层证据及影响
Tomoe Uchida,Aya Hirata
Tomoe Uchida
Waist circumference (WC) is widely used as a marker of central obesity in the diagnosis of metabolic syndrome (MetS) and it plays an important role in cardiovascular disease (CVD) risk screening. In Japan, the MetS diagnostic criteria estab...
A Phase 1 Study Evaluating the Pharmacokinetics, Pharmacodynamics, and Safety of Zerlasiran in Japanese Participants [0.03%]
泽拉西单抗在日本受试者中的药代动力学、药效学和安全性的I期研究
Henry Fok,Mariko Harada-Shiba,David Rider et al.
Henry Fok et al.
Aim: Zerlasiran is an N-acetylgalactosamine-conjugated small interfering RNA that targets lipoprotein(a), a risk factor for atherosclerosis and calcific aortic stenosis. Zerlasiran has not been studied in Japanese partici...
It's Time to Measure Lp(a): Recognizing a Neglected Cardiovascular Risk [0.03%]
重视Lp(a)检测：不可忽视的心血管风险因素
Hayato Tada,Masayuki Takamura
Hayato Tada
Lipoprotein(a) Distribution and Cardiovascular Risk in Japan: Insights from a Multi-center LEAP Study [0.03%]
日本脂蛋白(a)分布与心血管风险的相关性：来自多中心LEAP研究的启示
Tomoaki Yamada,Hayato Tada,Masatsune Ogura et al.
Tomoaki Yamada et al.
Aim: Although lipoprotein(a) [Lp(a)] is recognized as an independent risk factor for cardiovascular disease (CVD), its distribution and risk thresholds in the Japanese population remain unclear. This study aimed to charac...