Pyruvate kinase M2 and Serine Dehydratase are Upregulated in the Macrophages of Human Aortic Atherosclerotic Lesions via Inflammatory Stimuli [0.03%]
人动脉粥样硬化病灶的巨噬细胞中丙酮酸激酶M2和丝氨酸脱水酶通过炎症刺激而上调
Eriko Nakamura,Masanori Nishimura,Kazunari Maekawa et al.
Eriko Nakamura et al.
Aim: An altered vascular metabolism is closely linked to the cellular function in atherosclerotic lesions. The plasma pyruvate levels have been associated with aortic aneurysm progression in clinical studies. Pyruvate kin...
Isolated Low Levels of High-density Lipoprotein Cholesterol are Associated with an Increased Risk of Ischemic Cardiovascular Events: The Shizuoka Kokuho Database Study [0.03%]
孤立的高密度脂蛋白胆固醇低水平与缺血性心血管事件的风险增加有关：Shizuoka Kokuho数据库研究
Yasuharu Tabara,Sayaka Nagao-Sato,Aya Shoji-Asahina et al.
Yasuharu Tabara et al.
Aim: Isolated low high-density lipoprotein cholesterol (HDL-C) refers to low HDL-C levels with normal levels of triglycerides and low-density lipoprotein cholesterol. However, its prognostic significance remains controver...
Beyond Sinus Rhythm: Rhythm Control and Mechanism-Based Secondary Prevention in Atrial Fibrillation-Related Stroke [0.03%]
窦性心律之外：房颤卒中节律控制和机制为基础的二级预防策略
Yasuhiro Nishiyama
Yasuhiro Nishiyama
Atrial fibrillation is one of the most important causes of ischemic stroke and it is strongly associated with recurrent stroke, systemic embolism, heart failure, cognitive decline, and mortality. Oral anticoagulation, preferably direct oral...
Efficacy and Safety of Evinacumab in Japanese Patients with Homozygous Familial Hypercholesterolemia: Long-term Results from an Open-label, Single-arm, Phase 3 Trial [0.03%]
依那西普单臂开放性III期临床研究：依那西普治疗日本纯合子家族性高胆固醇血症患者的长期疗效和安全性分析结果
Masahiro Koseki,Hisashi Makino,Yoshihiko Otsubo et al.
Masahiro Koseki et al.
Aim: This sub-group analysis evaluated the long-term efficacy and safety of evinacumab, an angiopoietin-like 3 inhibitor, in adolescent and adult Japanese patients with homozygous familial hypercholesterolemia (HoFH) who ...
Knowledge Gaps and Nonadherence Among Japanese Patients with Atherosclerotic Cardiovascular Disease [0.03%]
日本动脉粥样硬化性心血管疾病患者的认知差距与不依从性
Mitsutoshi Toda,Kazuma Iekushi,Yuri Takahashi et al.
Mitsutoshi Toda et al.
Aim: Reducing low-density lipoprotein cholesterol (LDL-C) levels is crucial for preventing atherosclerotic cardiovascular disease (ASCVD). Recommended lipid-lowering therapy (LLT) includes both oral (e.g., statins) and in...
Association of Multimodal Intracoronary Imaging-Derived Plaque Morphology with the Pathophysiological Disease Patterns Assessed by the Quantitative Flow Ratio-Pullback Pressure Gradient [0.03%]
基于定量血流分数-拉力压力梯度评估的病理生理疾病模式与多模态光学相干断层扫描血管内成像斑块表型相关性研究
Eisuke Usui,Yoshihisa Kanaji,Masahiro Hada et al.
Eisuke Usui et al.
Aims: The quantitative flow ratio (QFR)-derived pullback pressure gradient (PPG) characterizes the pathophysiological patterns of coronary atherosclerosis. This study investigated the plaque morphologies associated with t...
Prognostic Significance of Atrial Cardiopathy in Patients with Embolic Stroke of an Undetermined Source [0.03%]
不明来源栓塞性卒中患者房颤 cardiopathy的预后意义
Yuan Chai,Lulu Pei,Lu Zhao et al.
Yuan Chai et al.
Aim: Atrial cardiomyopathy (AC) is associated with cardiovascular events, but the benefit of anticoagulation in embolic stroke of an undetermined source (ESUS) remains unclear. We aimed to prospectively evaluate the progn...
Masatsune Ogura
Masatsune Ogura