Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus [0.03%]
木果云香素通过改善2型糖尿病降低的细胞外液pH值防止脑胰岛素抵抗和淀粉样蛋白-β积聚
Shigekuni Hosogi,Atsukazu Kuwahara,Yuko Kuwahara et al.
Shigekuni Hosogi et al.
The present study tried to clarify if mumefural would prevent hyperglycemia, one of the typical symptoms of type 2 diabetes mellitus (T2DM), since mumefural is an extract from Japanese apricots preventing hyperglycemia. To clarify if mumefu...
GPRC5B (G protein-coupled receptor class C group 5 member B) suppresses glucose starvation-induced apoptosis in head-and-neck squamous cell carcinoma [0.03%]
G蛋白偶联受体C类5成员B(GPRC5B)抑制头颈部鳞状细胞癌的葡萄糖饥饿诱导凋亡
Keisuke Kanamori,Shigeyuki Ozawa,Hiroshi Iwabuchi et al.
Keisuke Kanamori et al.
G protein-coupled receptor class C group 5 member B (GPRC5B) is involved in extracellular glucose sensing, glucose metabolism, and insulin resistance. Many cancers require glucose at high concentrations to survive and grow. We have investig...
Secondary bile acid lithocholic acid attenuates neurally evoked ion transport in the rat distal colon [0.03%]
次级胆酸石胆酸减弱大鼠远端结肠神经介导的离子转运
Kohei Takahashi,Yuko Kuwahara,Ikuo Kato et al.
Kohei Takahashi et al.
The inhibitory action of the secondary bile acid lithocholic acid (LCA) on neurally evoked Cl-/HCO3- secretion was investigated using the Ussing-chambered mucosal-submucosal preparation from the rat distal colon. Electrical field stimulatio...
Selective estrogen receptor modulators, acting as agonists of estrogen receptor α in osteoblasts, reduce the TGF-β-induced synthesis of macrophage colony-stimulating factor via inhibition of JNK signaling pathway [0.03%]
选择性雌激素受体调节剂作为骨细胞的雌激素受体α激动剂，通过抑制JNK信号通路减少TGF-β诱导的巨噬殖民刺激因子的合成
Tomoyuki Hioki,Rie Matsushima-Nishiwaki,Haruhiko Tokuda et al.
Tomoyuki Hioki et al.
Selective estrogen receptor modulator (SERM) binds to estrogen receptors (ERs) and acts as both an agonist or an antagonist, depending on the target tissue. Raloxifene and bazedoxifene as SERMs are currently used hormone replacement medicin...
Consensus molecular subtyping improves the clinical usefulness of canonical tumor markers for colorectal cancer [0.03%]
共识分子分型可提高传统肿瘤标志物在结直肠癌中的临床应用价值
Hiroyasu Kagawa,Keiichi Hatakeyama,Akio Shiomi et al.
Hiroyasu Kagawa et al.
Transcriptome-based classification, such as consensus molecular subtyping, is expected to be applied to colorectal cancer (CRC). However, the relationship between molecular profiles and classical tumor markers, which are already used in cli...
Anatomical background of the sensory function in the urethra: involvement of endocrine paraneurons and afferent nerves in divergent urogenital functions. A review [0.03%]
尿道感觉功能的解剖学基础：内分泌旁神经元和传入神经在不同的泌尿生殖功能中的作用。综述
Toshihiko Iwanaga,Hiromi Takahashi-Iwanaga
Toshihiko Iwanaga
The urethra is ontogenetically derived from the cloaca together with distal parts of the large intestine, and serotonin cells are predominant among dispersed endocrine/paracrine cells in the epithelia of both tissues. Analysis of urethral e...
CD44 as a pathological marker for the early detection of calcineurin inhibitor-induced nephrotoxicity post kidney transplantation [0.03%]
CD44作为钙调神经磷酸酶抑制剂诱导的移植肾病理损伤早期标志物的研究
Asako Hayashi,Takayuki Okamoto,Junko Nio-Kobayashi et al.
Asako Hayashi et al.
Long-term calcineurin inhibitor (CNI) administration causes irreversible nephrotoxicity. Therefore, early CNI-induced nephrotoxicity detection is necessary for patients who will need long-term CNI administration. There is no pathological in...
Activation of STAT3 (signal transducer and activator of transcription 3) in synovial tissues from the hip joint in the early stage of rapidly destructive coxopathy [0.03%]
STAT3(信号转导及转录激活因子3)在早期破坏性髋关节病滑膜组织中的活化作用
Tadashi Yasuda,Shigeo Hara,Shinnosuke Yamashita et al.
Tadashi Yasuda et al.
Interleukin-6 signaling activates signal transducer and activator of transcription 3 (STAT3), resulting in matrix metalloproteinase-3 (MMP-3) production. The hip joints with rapidly destructive coxopathy (RDC) show rapid chondrolysis, proba...
Pathological examination of Ym1, a chitinase family protein, in Mesocestoides corti-infected mice [0.03%]
Ym1（软骨素酶家族蛋白）检测及在Mesocestoides corti感染小鼠体内的病理学研究
Junko Nio-Kobayashi,Makoto Owhashi,Toshihiko Iwanaga
Junko Nio-Kobayashi
Mammals express a set of chitinase family proteins, comprising chitinases, which can hydrolyze chitin, and chitinase-like proteins without the chitinase activity but possessing chitin-binding properties. They act as endogenous lectins, regu...
Structure and barrier functions of the perineurium and its relationship with associated sensory corpuscles: A review [0.03%]
感觉神经周围组织的结构与屏障功能及其与相关感觉体的关系：综述
Toshihiko Iwanaga,Hiromi Takahashi-Iwanaga,Junko Nio-Kobayashi et al.
Toshihiko Iwanaga et al.
Peripheral nerves are provided with a blood-nerve barrier which prevents the invasion of harmful substances and pathogens, and also regulates metabolic and ionic homeostasis within nerve fascicles. The barrier functions are attributed to bo...