Cyclooxygenase-2 induction by lysophosphatidylcholine in cultured rat vascular smooth muscle cells: involvement of the p38MAPK pathway [0.03%]
lysophosphatidylcholine诱导的大鼠血管平滑肌细胞中环氧合酶-2的表达：涉及p38MAPK途径
Tadashi Yamakawa,Keizo Ohnaka,Shun-Ichi Tanaka et al.
Tadashi Yamakawa et al.
Lysophosphatidylcholine (lysoPC) stimulates the release of prostaglandins (PGs) in various cells and tissues. Cyclooxygenase (COX)-2 has recently emerged as a key regulator of PG synthesis. We investigated whether lysoPC regulates COX-2 exp...
Eye-concentrated distribution of dexamethasone carried by sugar-chain modified liposome in experimental autoimmune uveoretinitis mice [0.03%]
糖链修饰脂质体载糖皮质激素在实验性自身免疫性葡萄膜炎眼内的浓度分布
Yukio Arakawa,Noriyasu Hashida,Nobuyuki Ohguro et al.
Yukio Arakawa et al.
Corticosteroid is generally accepted as a standard therapeutic agent for active inflammatory (and) autoimmune eye diseases. In an attempt to develop a system to deliver corticosteroid most efficiently to the target eye, a sialyl-Lewis X (sL...
Gadolinium chloride suppresses styrene-induced cytochrome P450s expression in rat liver [0.03%]
氯化 gadolinium 抑制氯乙烯诱导的大鼠肝 p450 表达
Fujiko Hirasawa,Masami Kawagoe,Jing-Shu Wang et al.
Fujiko Hirasawa et al.
To assess the effect of gadolinium (Gd) on the expression of several forms of cytochrome P450 (P450s) and antioxidant enzymes, we treated rats with gadolinium chloride (25 mg as Gd/kg body weight) 4 h after styrene (a multiple P450 inducer)...
IL-1beta stimulates urokinase-type plasminogen activator expression and secretion in human dental pulp cells [0.03%]
IL-1beta刺激人牙髓细胞的尿激酶型纤溶酶原激活器的表达和分泌
Naoto Kamio,Hideki Hashizume,Sumi Nakao et al.
Naoto Kamio et al.
Plasminogen activator (PA) is the enzyme that converts plasminogen to its active form, plasmin, which is involved in various physiological and pathological phenomena. The conversion is catalyzed by two types of PA, urokinase-type PA (uPA) a...
Effects of long-term estradiol treatment on the contractile response to muscarine and muscarinic receptor subtypes in the bladder of aged female rats [0.03%]
长期雌二醇治疗对老年雌性大鼠膀胱胆碱能收缩反应及受体亚型的影响
Mayuko Matsumoto,Takeshi Watanabe,Ikuo Miyagawa
Mayuko Matsumoto
In this study, we tried to elucidate the effect of estrogen treatment on the detrusor contractile response to muscarine and muscarine receptor subtypes of the bladder in 13-month-old female Wistar rats. The rats were divided into two groups...
Impairment and restoration of spontaneous contractile activity of longitudinal smooth muscles in the TNBS-inflamed hamster distal colon [0.03%]
TNBS诱导的恒格氏鼠远端结肠纵向平滑肌自发收缩能力的损伤与修复
Yam B Gurung,Yasutake Shimizu,Takahiko Shiina et al.
Yam B Gurung et al.
In the present study, we aimed to determine how inflammation affects spontaneous motility in the longitudinal direction of a hamster colon preparation. Trinitrobenzene sulfonic acid (TNBS) injected into the distal colon caused diarrhea 4-7 ...
AMP N1-oxide potentiates astrogenesis by cultured neural stem/progenitor cells through STAT3 activation [0.03%]
AMP N1-氧化物通过激活STAT3促进神经干细胞/前体细胞的星形化作用
Noriko Hattori,Hiroshi Nomoto,Hidefumi Fukumitsu et al.
Noriko Hattori et al.
We earlier identified adenosine monophosphate (AMP) N1-oxide as a unique compound of royal jelly (RJ) that induces neurite outgrowth from cultured rat pheochromocytoma PC12 cells. In the present study, the effects of AMP N1-oxide on the pro...
Relationship between serum cholinesterase level and urinary bladder activity in patients with or without overactive bladder and/or neurogenic bladder [0.03%]
正常膀胱、过度活动膀胱及神经源性膀胱患者血清胆碱酯酶水平与膀胱尿动力学参数之间的关系
Kimio Sugaya,Tomohiro Onaga,Saori Nishijima et al.
Kimio Sugaya et al.
We compared the serum cholinesterase (ChE) level and various parameters between patients with or without overactive bladder (OAB) and/or neurogenic bladder (NB). A total of 258 patients who met the following criteria were enrolled: the pres...
Laughter up-regulates the genes related to NK cell activity in diabetes [0.03%]
笑可以上调与自然杀伤细胞活性有关的基因以辅助糖尿病治疗
Takashi Hayashi,Satoru Tsujii,Tadao Iburi et al.
Takashi Hayashi et al.
To elucidate the sustainable effects of laughter on gene expression, we recruited type 2 diabetic patients who were in-patient for receiving self-management education and examined time-dependent regulation for gene expression by laughter. T...