GP2-expressing cells: a new guardian with divergent functions in the intestine, eyes, and nose [0.03%]
GP2表达细胞：肠道、眼睛和鼻腔中功能多样的新守护者
Toshihiko Iwanaga,Shunsuke Kimura
Toshihiko Iwanaga
GP (glycoprotein)-2, originally identified as a predominant membranous component of pancreatic acinar cells, has attracted the interest of researchers in mucosal immunology for its role as a functional molecule specific for antigen-sampling...
3-Iodothyronamine, a trace amine-associated receptor agonist, regulates intracellular Ca2+ increases via CaMK II through Epac2 in rat cerebral arterioles [0.03%]
3-碘甲状腺素胺通过Epac2和CaMK II调节大鼠脑小动脉内Ca2+的增加
Wakana Sakanoue,Takuya Yokoyama,Masato Hirakawa et al.
Wakana Sakanoue et al.
Trace amines (TAs) in the nervous system bind to TA-associated receptors (TAARs) and are involved in the regulation of monoaminergic functions. Among TAAR subtypes, TAAR1 has been implicated in the development of neurological disorders, suc...
Acute effect of electrical stimulation on muscle protein synthesis and break-down in the soleus muscle of hindlimb unloaded rats [0.03%]
电刺激对失载大鼠腓肠肌蛋白合成及降解的急性影响
Miho Kanazashi,Masayuki Tanaka
Miho Kanazashi
Electrical stimulation (ES) is effective for disuse-induced muscle atrophy. However, the acute effect of ES on muscle protein synthesis (MPS) and muscle protein breakdown (MPB) remains unclear. We investigated the effect of a single-session...
Protective effects of hachimijiogan (HJG), a Japanese Kampo medicine, on cancer cachectic muscle wasting in mice [0.03%]
日本汉方药八味地黄丸对癌恶病质小鼠肌肉萎缩的保护作用研究
Satoshi Kametaka,Mari Isobe,Kenshin Komata et al.
Satoshi Kametaka et al.
Myogenesis is required to generate skeletal muscle tissue and to maintain skeletal muscle mass. Decreased myogenesis under various pathogenic conditions results in muscular atrophy. Through a small screening of Japanese traditional (Kampo) ...
Impact of somatic mutations and transcriptomic alterations on cancer aneuploidy [0.03%]
染体不整倍体现在癌症中的影响：拷贝数改变与转录组改变之间的关系研究
Keiichi Hatakeyama,Takeshi Nagashima,Keiichi Ohshima et al.
Keiichi Hatakeyama et al.
Aneuploidy has been recognized as one of hallmark of tumorigenesis since the early 20th century. Recent developments in structural variation analysis in the human genome have revealed the diversity of aneuploidy in cancer. However, the effe...
Validation of mitotic harvesting method with human cervical carcinoma HeLa cells expressing fluorescent ubiquitination-based cell cycle indicators for radiation research [0.03%]
一种用于放射研究的HeLa细胞（人宫颈癌）表达荧光泛素化周期指标的有丝分裂收获方法验证
Ryosuke Seino,Hiroto Uno,Hisanori Fukunaga
Ryosuke Seino
The cell cycle is a series of events in the process of one cell giving rise to two daughter cells. The mitotic harvesting method, established by Terasima and Tolmach in the 1960s, causes minimal physiological stress on the cells and achieve...
Visualization of the localization of phospholipids in developing rat teeth by matrix-assisted laser desorption/ionization imaging mass spectrometry [0.03%]
MALDI质谱成像技术在大鼠乳牙发育过程中对卵磷脂定位研究中的应用
Yasuyuki Sasano,Alu Konno,Megumi Nakamura et al.
Yasuyuki Sasano et al.
Matrix-assisted laser desorption/ionization imaging mass spectrometry (IMS) is used to comprehensively visualize the spatial distribution of numerous biomolecules. The present study was designed to investigate the distribution of phospholip...
Comparative analysis of tumor content estimation methods based on simu- lated tumor samples identified their impact on somatic variant detection in cancer whole genome sequencing [0.03%]
基于模拟肿瘤样本的肿瘤含量估算方法比较分析及其对癌症全基因组测序体细胞变异检测的影响比较研究
Takeshi Nagashima,Kenichi Urakami,Yuji Shimoda et al.
Takeshi Nagashima et al.
Whole genome sequencing (WGS) in cancer genomics has become widespread with recent technological innovations, and the amount and types of information obtained from WGS are increasing rapidly. Appropriate interpretation of results is becomin...
Neonatal bilateral whisker trimming in male mice age-dependently alters brain neurotransmitter levels and causes adolescent onsets of social behavior abnormalities [0.03%]
新生鼠双侧须切除术雄性小鼠年龄依赖性地改变脑内神经递质水平并导致青春期社会行为异常发生
Hiroyasu Murasawa,Hitomi Soumiya,Hiroyuki Kobayashi et al.
Hiroyasu Murasawa et al.
Tactile perception via whiskers is important in rodent behavior. Whisker trimming during the neonatal period affects mouse behaviors related to both whisker-based tactile cognition and social performance. However, the molecular basis of the...
A point of view on human fat olfaction - do fatty derivatives serve as cues for awareness of dietary fats? [0.03%]
人体脂肪嗅觉的观点-脂肪衍生物能否作为感知膳食脂肪的信号分子？
Satoshi Tsuzuki
Satoshi Tsuzuki
Fat (triglycerides) consumption is critical for the survival of animals, including humans. Being able to smell fat can be advantageous in judging food value. However, fat has poor volatility; thus, olfaction of fat seems impossible. What ab...